Latest updates for Neurodegeneration

Fresh curated links around neurodegeneration are collected here so marketers can spot useful updates and turn timely ideas into posts faster.

Recent items include:

  • Oxidative signaling thresholds shape vulnerability in the central and peripheral nervous systems
  • Why are some neurons spared in neurodegeneration? Cellular subtype identity maintenance as a candidate threshold-setting
  • Cellular diversity in neural organoids is critical for neurodegenerative disease modeling

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journals.plos.org /5 days ago

Oxidative signaling thresholds shape vulnerability in the central and peripheral nervous systems

by Shuji Wakatsuki, Toshiyuki Araki Neurodegeneration is frequently associated with oxidative stress, yet the mechanisms that convert reactive oxygen species (ROS) into irreversib...

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journals.plos.org /2 weeks ago

Why are some neurons spared in neurodegeneration? Cellular subtype identity maintenance as a candidate threshold-setting...

by Dong Won Kim Neurodegenerative diseases often damage some neuronal populations while sparing closely related neighbors. But instead of asking why some neurons die, should we be...

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journals.plos.org /1 week ago

Cellular diversity in neural organoids is critical for neurodegenerative disease modeling

by Shiying Liu, Shi-Yan Ng Neuroinflammation and vascular dysfunction are hallmarks of most neurodegenerative diseases. For organoids intended to model neurodegeneration, immune,...

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fightaging.org /1 month ago

NRF2 Downregulation in Oligodendrocytes as a Contributing Cause of Cognitive Decline in Mice

Oligodendrocytes resident in the brain are responsible for maintaining the insulating myelin sheaths around axons that are required for the effective transmission of electrical imp...

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huffingtonpost.co.uk /1 month ago

Brain Changes Between 50 And 75 Could Trigger Neurodegeneration

A previous study has suggested that our brains are technically in their adolescent phase until about 32, with the adulthood section running ’til about 66.But a new paper published...

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bioengineer.org /1 month ago

New mechanistic pathways link oxidative stress to neurodegeneration

The human brain is an extraordinarily expensive organ to run. Although it accounts for only about two percent of body mass, it devours roughly twenty percent of the body’s oxygen s...

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multiple-sclerosis-research.org /1 month ago

Where is the action of anti-CD20 and other antibodies on Neurodegeneration

Nerve damage is a consequence of poorly controlled MS and in one place it is easy to monitor nerve damage and this is in the eye. The eye is connected to your brain and nerve damag...

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bioengineer.org /1 week ago

Mitochondrial protein CHCHD2 emerges as a guardian of the aging brain

New research shows that the age-related decline of the mitochondrial protein CHCHD2 disrupts the mitochondria-lysosome axis and drives proteostatic collapse in Lewy body disorders,...

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fightaging.org /1 month ago

The State of Development for Therapies to Treat Tauopathies

The major neurodegenerative conditions are characterized by pathology deriving from a small number of misfolded or otherwise altered proteins. Amyloid-β misfolding and aggregation...

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braingle.com /1 month ago

Alzheimer's Disease

Alzheimer's disease is a degenerative disease of the nerve cells in the brain that causes impairment of memory and other brain functions -- such as language or perception of realit...

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bioengineer.org /2 weeks ago

Hidden Brain Cells Called Oligodendrocytes Emerge as Unexpected Drivers of Parkinson’s Disease

A spatial multi-omics study in Nature Communications identifies disease-associated oligodendrocytes whose interleukin 33–ST2 signaling influences alpha-synuclein burden and motor s...

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fightaging.org /1 month ago

Senescent Microglia Secrete DLK1, Which Causes Dysfunction in the Aging Brain

Senescent cells accumulate with age in tissues throughout the body, disrupting tissue structure and function with inflammatory secretions. The growing burden of senescent cells is...

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scitechdaily.com /1 month ago

Brain Cells Once Thought Protective May Actually Drive Cognitive Decline With Age

Age-related oligodendrocyte dysfunction may contribute to cognitive decline by disrupting myelin and large nerve fibers. Myelin is essential for fast communication in the brain, fo...

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fightaging.org /1 month ago

Different Parts of the Brain Exhibit Different Vulnerability to Synucleinopathy

Parkinson's disease and Lewy body dementia are synucleinopathies, characterized by the spread of misfolded α-synuclein through the central nervous system. The presence of misfolded...

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bioengineer.org /2 weeks ago

Beyond ALS: Misfolded SOD1 Emerges as a Shared Player in Brain Disease

A sweeping review of human neuropathological evidence shows that misfolded SOD1, long tied to familial ALS, coexists with TDP-43, tau, alpha-synuclein, and amyloid-beta across mult...

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genengnews.com /3 weeks ago

Antibody Blocks T Cell Infiltration and Limits Neurodegeneration in Alzheimer’s Mice

Researchers developed a potential antibody-based approach to reducing neurodegeneration in tauopathies, with studies showing that in a mouse Alzheimer’s model anti-CXCR3-treated an...

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sciencedaily.com /1 week ago

Brain cells meant to protect us may be fueling cognitive decline

Scientists have uncovered a surprising cause of age-related cognitive decline involving brain cells previously thought to be entirely beneficial. As these cells become dysfunctiona...

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genengnews.com /1 month ago

Immune Cells Driving Alzheimer’s-Like Neurodegeneration Traced to Lymph Nodes

A study in mice traces immune cells that drive neurodegeneration to the body’s lymph nodes, suggesting that processes outside the brain contribute to the damage seen in various tau...

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fightaging.org /1 month ago

Reprogramming Glia into Neurons Becomes Less Effective with Advancing Age

The research community is in the early stages of development of therapies for age-related neurodegeneration based on reprogramming the supporting glial cells of the brain to provok...

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journals.plos.org /1 week ago

Does perturbed adaptive myelination contribute to cognitive dysfunction in Alzheimer’s disease?

by Charles ffrench-Constant The consequences of oligodendrocyte involvement in Alzheimer’s disease are poorly understood. Could a key role of gray-matter oligodendrocytes—activity...

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thehindu.com /1 month ago

Peripheral inflammation may drive brain damage in rare neurological disorder, finds NIMHANS study

Researchers identify link that could aid earlier diagnosis of Progressive Supranuclear Palsy 

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genengnews.com /1 month ago

Genes Involved in Flatworm Brain Regeneration Identified

Researchers identified genes that enable the regeneration of dopamine-producing neurons in planarians. This provides a roadmap for investigating whether similar pathways can be act...

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scitechdaily.com /1 month ago

Depression in Later Life May Be an Early Warning Sign of Alzheimer’s

Depression in later life may be an early warning from the brain, appearing years before Alzheimer’s begins to affect memory and thinking A new study in JNeurosci found that faster...

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fightaging.org /1 month ago

There is Such a Thing as Too Much of a Focus on the Brain in Neurodegenerative Disease

Every tissue in the body exchanges signals with every other tissue. Every tissue is dependent on specialized functions that are conducted elsewhere in the body. Thus in the matter...

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Sources covering Neurodegeneration

feeds.braingle.com

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feeds.feedburner.com

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huffingtonpost.co.uk

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bioengineer.org

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feeds.feedburner.com

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journals.plos.org

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