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Can pinpointing a cognition-selective glycine transporter restore receptor function and reverse autism-related behaviors in adults? A new study identified the transporter SLC6A20 a...
Can an overactive synaptic protein hold the key to treating the most common genetic cause of autism? A new study identifies the protein EPAC2 as a potent drug target for reversing...
An antisense therapy that targets a glycine transporter restored NMDA receptor function in mouse models related to autism and in human brain organoids. An overlooked protein that r...
The therapy restored FMRP expression in crucial brain regions, resulting in reduced audiogenic seizure susceptibility, normalized sensory hyperactivity, and complete reversal of el...
Researchers identified the synaptic protein EPAC2 as a potential therapeutic target for fragile X syndrome, and showed that blocking EPAC2 in an FXS mouse model restored abnormal p...
A new study demonstrated a cellular neighborhood effect, where mutant cells actively warp the gene expression of neighboring healthy neurons, revealing that early circuit wide-dama...
Shank3 mutant laboratory Beagles could bridge the 90% failure gap in autism drug development, as their uniquely co-evolved social architecture allows them to mirror human-like soci...
How do abstract genetic mutations physically alter human brain wiring? A functional genomics study bridges the gap between schizophrenia genetics and cellular neurobiology.
A new study revealed that hundreds of diverse genetic causes of autism converge on shared molecular pathways.
New research, led by scientists from the Seaver Autism Center for Research and Treatment at Mount Sinai and published in Autism Research, has estimated that Phelan-McDermid syndrom...
RNA sequencing with regRNA Capture-seq identified thousands of regulatory RNAs and enabled new strategies to increase expression of disease-related genes using ASOs...
A collaborative study used whole-genome sequencing to examine the genetic makeup of 110 children from Aosta Valley (Valle d'Aosta) with neurodevelopmental disorders and their paren...
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