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TAP-seq combines genome editing with targeted RNA sequencing to enable sensitive and cost-effective single-cell functional genomics screens...
New spatial RNA sequencing technology links large-scale CRISPR perturbations to tumor growth, metastasis, immune responses, and complex RNA regulation within intact tissues... The...
STGBench generates realistic paired DNA and RNA sequencing datasets with known genetic alterations, enabling accurate benchmarking of spatial genomics and transcriptomics analysis....
A new APA-seq analysis method improves differential gene expression detection, helping researchers gain deeper insights from RNA sequencing data and alternative polyadenylation stu...
by Noam Teyssier, Alexander Dobin Modern genomics produces billions of sequencing records per run, which are typically stored as gzip-compressed FASTQ files. While this format is...
segSHAPE improves RNA sequencing signal alignment and modification detection, enabling more accurate secondary structure predictions from individual RNA molecules across multiple c...
Benchmarking five RNA velocity methods reveals how sequencing depth and biological complexity influence trajectory predictions from single-cell RNA sequencing data... The post Comp...
by Sarah Ancheta, Leah Dorman, Guillaume Le Treut, Abel Gurung, Greg Huber, Loïc A. Royer, Alejandro Granados, Merlin Lange Single-cell RNA sequencing is revolutionizing our under...
D&D‑seq uses a base editor–nanobody fusion to record DNA–protein contacts at single‑cell resolution. The method maps transcription factor and chromatin-remodeling proteins. The...
by Araf Mahmud, Chen Huang Alternative splicing affects 95% of multi-exon genes, generating protein isoforms with distinct functions. While current alternative splicing analyses e...
RNA sequencing with QutRNA2 enables faster, more accurate detection of transfer RNA modifications from direct Nanopore sequencing, supporting large scale studies of RNA biology...
..Nanopore RNA sequencing models can detect RNA modifications, but benchmark results reveal significant false positives and highlight the importance of controls for accurate epitra...
Eclipse Bioinnovations uses RNA sequencing in eSENSE Breakâ„¢ to map RNA fragmentation at single-nucleotide resolution, helping developers understand RNA stability and structural v...
PANDORA-seq revealed sperm small RNA signatures associated with motility and morphology, providing new molecular markers for assessing male fertility...
Amaranth improves transcript reconstruction from RNA sequencing data by modeling different read types, enabling more accurate isoform analysis at single-cell resolution...
RNA sequencing from more than 22 million cells trained a model that predicts cell-type-specific gene expression and noncoding variant...
This Parse Biosciences and bit.bio alliance combines single-cell RNA sequencing and causal transcriptomics to map transcription factor-driven cell identity, enabling improved disea...
RNA sequencing combined with high-throughput functional profiling enabled researchers to build complete riboswitch models and uncover coordinated structural changes involved in gen...
Nanopore direct RNA sequencing enables accurate, site-specific quantification of pseudouridine modifications in human ribosomal RNA, expanding opportunities for large-scale epitran...
A new RNA sequencing workflow using nanopore technology improves full-length lncRNA isoform discovery, revealing many previously undetected transcripts missed by conventional short...
by Zhenhui He, Dong Kangning Resolving fine-grained cell subtypes in single-cell RNA sequencing (scRNA-seq) data remains challenging, as their subtle transcriptional differences a...
RNA sequencing supports space biology research by enabling transcriptome-wide analysis of gene expression changes associated with spaceflight and adaptation to space environments.....
MERCURIUSâ„¢ 1536 DRUG-seq brings RNA sequencing to large-scale compound screening, enabling efficient gene expression profiling... The post Alithea Genomics launches early access...
RNA sequencing using nanopore direct RNA sequencing enables simultaneous analysis of native RNA molecules, transcript isoforms, RNA modifications, and poly(A) tails for comprehensi...
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