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Alzheimer's disease is a degenerative disease of the nerve cells in the brain that causes impairment of memory and other brain functions -- such as language or perception of realit...
by Shiying Liu, Shi-Yan Ng Neuroinflammation and vascular dysfunction are hallmarks of most neurodegenerative diseases. For organoids intended to model neurodegeneration, immune,...
by Dong Won Kim Neurodegenerative diseases often damage some neuronal populations while sparing closely related neighbors. But instead of asking why some neurons die, should we be...
A sweeping review of human neuropathological evidence shows that misfolded SOD1, long tied to familial ALS, coexists with TDP-43, tau, alpha-synuclein, and amyloid-beta across mult...
Oligodendrocytes resident in the brain are responsible for maintaining the insulating myelin sheaths around axons that are required for the effective transmission of electrical imp...
by Shuji Wakatsuki, Toshiyuki Araki Neurodegeneration is frequently associated with oxidative stress, yet the mechanisms that convert reactive oxygen species (ROS) into irreversib...
The major neurodegenerative conditions are characterized by pathology deriving from a small number of misfolded or otherwise altered proteins. Amyloid-β misfolding and aggregation...
A spatial multi-omics study in Nature Communications identifies disease-associated oligodendrocytes whose interleukin 33–ST2 signaling influences alpha-synuclein burden and motor s...
Researchers identify link that could aid earlier diagnosis of Progressive Supranuclear Palsy
Senescent cells accumulate with age in tissues throughout the body, disrupting tissue structure and function with inflammatory secretions. The growing burden of senescent cells is...
Parkinson's disease and Lewy body dementia are synucleinopathies, characterized by the spread of misfolded α-synuclein through the central nervous system. The presence of misfolded...
Every tissue in the body exchanges signals with every other tissue. Every tissue is dependent on specialized functions that are conducted elsewhere in the body. Thus in the matter...
New research shows that the age-related decline of the mitochondrial protein CHCHD2 disrupts the mitochondria-lysosome axis and drives proteostatic collapse in Lewy body disorders,...
The human brain is an extraordinarily expensive organ to run. Although it accounts for only about two percent of body mass, it devours roughly twenty percent of the body’s oxygen s...
A previous study has suggested that our brains are technically in their adolescent phase until about 32, with the adulthood section running ’til about 66.But a new paper published...
Depression in later life may be an early warning from the brain, appearing years before Alzheimer’s begins to affect memory and thinking A new study in JNeurosci found that faster...
Age-related oligodendrocyte dysfunction may contribute to cognitive decline by disrupting myelin and large nerve fibers. Myelin is essential for fast communication in the brain, fo...
Sporadic CJD is the most common form, but variant and familial types also affect humans.
A large trans-disease meta-analysis of more than 6,900 brain scans finds that Alzheimer's disease and multiple sclerosis share a common grey matter atrophy pattern in the superior...
Salk Institute scientists found that immune cells in the central nervous system identify and kill specific nerve cells in the spinal cords of mice with late-stage ALS, worsening th...
by Charles ffrench-Constant The consequences of oligodendrocyte involvement in Alzheimer’s disease are poorly understood. Could a key role of gray-matter oligodendrocytes—activity...
A sweeping new analysis of more than a quarter century of American death records has found that while the absolute number of people dying from motor neuron disease in the United St...
Huntington’s disease is an inherited condition that gradually robs people of their ability to move, speak and even think clearly—there is no cure
A study in mice traces immune cells that drive neurodegeneration to the body’s lymph nodes, suggesting that processes outside the brain contribute to the damage seen in various tau...
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