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Alzheimer's disease is a degenerative disease of the nerve cells in the brain that causes impairment of memory and other brain functions -- such as language or perception of realit...
by Shiying Liu, Shi-Yan Ng Neuroinflammation and vascular dysfunction are hallmarks of most neurodegenerative diseases. For organoids intended to model neurodegeneration, immune,...
by Dong Won Kim Neurodegenerative diseases often damage some neuronal populations while sparing closely related neighbors. But instead of asking why some neurons die, should we be...
The major neurodegenerative conditions are characterized by pathology deriving from a small number of misfolded or otherwise altered proteins. Amyloid-β misfolding and aggregation...
A sweeping review of human neuropathological evidence shows that misfolded SOD1, long tied to familial ALS, coexists with TDP-43, tau, alpha-synuclein, and amyloid-beta across mult...
A spatial multi-omics study in Nature Communications identifies disease-associated oligodendrocytes whose interleukin 33–ST2 signaling influences alpha-synuclein burden and motor s...
by Shuji Wakatsuki, Toshiyuki Araki Neurodegeneration is frequently associated with oxidative stress, yet the mechanisms that convert reactive oxygen species (ROS) into irreversib...
The human brain is an extraordinarily expensive organ to run. Although it accounts for only about two percent of body mass, it devours roughly twenty percent of the body’s oxygen s...
Parkinson's disease and Lewy body dementia are synucleinopathies, characterized by the spread of misfolded α-synuclein through the central nervous system. The presence of misfolded...
Oligodendrocytes resident in the brain are responsible for maintaining the insulating myelin sheaths around axons that are required for the effective transmission of electrical imp...
Every tissue in the body exchanges signals with every other tissue. Every tissue is dependent on specialized functions that are conducted elsewhere in the body. Thus in the matter...
Biomarkers that reflect the brain’s workings have been difficult to pin down in neurology studies, but the field has come a long way. The post Changing with the times: what is the...
A large trans-disease meta-analysis of more than 6,900 brain scans finds that Alzheimer's disease and multiple sclerosis share a common grey matter atrophy pattern in the superior...
A sweeping new analysis of more than a quarter century of American death records has found that while the absolute number of people dying from motor neuron disease in the United St...
New research shows that the age-related decline of the mitochondrial protein CHCHD2 disrupts the mitochondria-lysosome axis and drives proteostatic collapse in Lewy body disorders,...
Senescent cells accumulate with age in tissues throughout the body, disrupting tissue structure and function with inflammatory secretions. The growing burden of senescent cells is...
Learn how brain tissue donated to science after death gives clues about genetic changes in neurological disorders and how we might target them better in future patients.
Age-related oligodendrocyte dysfunction may contribute to cognitive decline by disrupting myelin and large nerve fibers. Myelin is essential for fast communication in the brain, fo...
Salk Institute scientists found that immune cells in the central nervous system identify and kill specific nerve cells in the spinal cords of mice with late-stage ALS, worsening th...
The NIH is recruiting a postdoctoral researcher to advance long-read RNA sequencing methods for studying gene regulation, transcript diversity, and RNA modifications in neurodegene...
Nerve damage is a consequence of poorly controlled MS and in one place it is easy to monitor nerve damage and this is in the eye. The eye is connected to your brain and nerve damag...
Depression in later life may be an early warning from the brain, appearing years before Alzheimer’s begins to affect memory and thinking A new study in JNeurosci found that faster...
Many of the more sophisticated forms of medicine, including gene therapies and immunotherapies, are challenging to deliver to the brain. At the very least there are far fewer pract...
by Charles ffrench-Constant The consequences of oligodendrocyte involvement in Alzheimer’s disease are poorly understood. Could a key role of gray-matter oligodendrocytes—activity...
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