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Cells do not become specialized in a single instant. During development, they gradually change their molecular programs, position, shape, polarity and behavior before reaching a ma...
Two DNA-recording systems traced cellular family trees across mouse embryogenesis, offering new insight into how organs form and when developing cells commit to specific fates. The...
Before most women know they're pregnant, an embryo has already begun organizing itself into the structures that will shape a developing body. Scientists have few opportunities to s...
by Marine Fontaine, M. Joaquina Delás, Meritxell Sáez, Rory J. Maizels, Elizabeth Finnie, James Briscoe, David A. Rand Building a mechanistic understanding of cell fate decisions...
by Christopher J. Johnson, Joshua Kavaler, Timethea Slade, Kayla Wilson, Christina D. Cota, Alberto Stolfi Tunicates are the sister group to vertebrates within the chordate phylum...
A map built from more than 14,000 embryo cells reveals what stem cell models get right about early human development and where researchers could improve them. Under a microscope, a...
by Ben R. Hopkins, Olga Barmina, Xinying Wang, Mandy M. Situ, Haley A. Bolanos, Shizhan Nie, Artyom Kopp The individualization of serially repeated homologs is one route through w...
Researchers developed a method for testing how closely lab-grown blastoid models resemble real human embryos, finding that while some models perform well, none fully captures the c...
by Nikolas Drummond, Arthur Zhao, Alexander Borst T4 and T5 neurons are the first direction-selective neurons in the visual pathway. They are the most numerous cell types in the f...
by Alicia Lou, Juan F. Poyatos, Monica Chagoyen Housekeeping genes are commonly defined as broadly expressed genes that support essential cellular function. However, their identif...
by Zoe R. Sudderick, Tiernan Briggs, Shirooza Mubarak, Melinda Van Kerckvoorde, Ana R. Hernandez Rodriguez, Sudeepta K. Panda, Jon Riddell, Cameron Batho-Samblas, Lorna Taylor, Lyn...
Single-cell RNA sequencing reveals extensive cellular reprogramming during acorn worm metamorphosis, showing that many larval cells persist while adopting different adult cell iden...
by Phillip L. Davidson, Isabel G. Manley, Armin P. Moczek Condition-responsive growth is a common feature of multicellular development, during which organisms integrate genetic an...
by Kazunori Ando, Sushant Bangru, John Welsby, John D. Thompson, Kenneth D. Poss Regeneration programs enable animals to restore damaged or lost tissues, and the range of stimuli...
by Anahí Binagui-Casas, Anna Granés, Alberto S. Ceccarelli, Matthew French, Filip J. Wymeersch, Rosa Portero Migueles, Jennifer Annoh, Yali Huang, Eleni P. Karagianni, Frederick C....
by Sarah Frieda Becker, Marie-Charlotte Morin, Julien Lambert, Shashi Kumar Suman, Francesco Nicola Carelli, Alex Appert, Stéphane Roth, Sarah Hoff-Yoessle, Jessica D. Medina-Sanch...
A comparative study in two beetle species links evolving regulatory DNA and condition-specific chromatin changes to horn diversification, with functional evidence for two BMP-pathw...
New work in Arabidopsis reveals that an embryo-derived PIPL7 peptide signals through the IKU2 receptor kinase to polarize MINI3 expression and direct endosperm cellularization duri...
Roughly one in ten Americans lives with a neurodevelopmental condition, yet for decades scientists have struggled to answer a deceptively simple question: where, when, and how do t...
Cephalopods, like the octopus, have specialized arms and suckers, but how these structures evolved from the simple bodies of their mollusk ancestors remains a mystery. Researchers...
by Tal Gordon, Tom Levy, Chester Jiamu Yu, Benyamin Rosental, Lauren Lubeck, Lucia Manni, Irving L. Weissman, Ayelet Voskoboynik Many tissues harbor quiescent stem cells that acti...
by Amanda A. G. Ferreira, Sergio Córdoba, Raghuvanshi Rajesh, Ben Jiwon Choi, Claude Desplan Glial cells are essential for proper nervous system development and function. To under...
by Juan Lan Tan, Adele Barugahare, Andrew Thomas Major, Craig Allen Smith In vertebrate embryos, Müllerian ducts give rise to the female reproductive tract. Here, we present a com...
In the earliest hours of a sea lamprey embryo’s life, something remarkable happens. As its cells divide, vast stretches of genetic material—entire chromosomes—are...
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