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In a landmark advancement that could redefine molecular diagnostics, researchers have unveiled a groundbreaking DNA-guided CRISPR–Cas12a system capable of programmable RNA recognit...
In a remarkable leap forward in gene editing technology, researchers at The Hong Kong University of Science and Technology (HKUST) have developed the world’s first DNA-guided CRISP...
A newly characterized Cas12f nuclease shows strong editing in human cells. Researchers engineered a variant with markedly improved efficiency, advancing efforts toward compact geno...
by Lisa H. Verzier, Eva Hesping, Marcel Doerflinger, Marco J. Herold, Justin A. Boddey Sporozoites of Plasmodium falciparum, the deadliest malaria parasite, are injected into the...
The rapid evolution of CRISPR/Cas genome editing has redefined the possibilities of cellular and gene therapy, enabling precise correction, disruption, and regulation of disease-as...
The platform, called ΨDNA, reprograms Cas12 nucleases to recognize and act on RNA using a DNA-based guide scaffold. In human cell lines, ΨDNA achieved 70–95% knockdown of endogenou...
New gene-editing techniques exploit unique chemical fingerprints in cancer DNA to selectively destroy tumor cells, paving the way for precision therapy.
The CEO of Caszyme, a biotech company in Vilnius, Lithuania, presented details of Cas12l, a novel compact Cas nuclease with a variety of potential research and therapeutic applicat...
In a groundbreaking development that could redefine antiviral therapy, researchers have engineered a CRISPR-Cas13d based system to combat hepatitis E virus (HEV) infection with rem...
The CRISPR-Cas gene-editing system has long been the focus of research as a promising tool in genome editing. However, the emphasis has been on its underlying mechanisms and nuclea...
New CRISPR tool shreds targeted cells instead of editing genes, showing promise for killing diseased cells while sparing healthy ones.
Scientists have devised a CRISPR-based tool that can kill cells carrying a specific strand of RNA. The tested targets include cancerous and virus-infected cells [1]. Targeted assas...
In a groundbreaking advancement at the intersection of genome engineering and biocontainment, researchers at Seoul National University have developed a pioneering technology enabli...
Researchers have used modified CRISPR to silence the extra chromosome 21 in Down syndrome cells, showing promising preclinical results. The post Modified CRISPR tool targets Down s...
A Phase I/II clinical trial shows that a stem cell transplant that removes CD33 from donor cells using CRISPR can prevent cancer recurrence. The post Acute Myeloid Leukemia Therapy...
Scientists at the Korea Advanced Institute of Science and Technology (KAIST), in collaboration with researchers at the University of California, Berkeley and the Gladstone Institut...
A new prime assembly technique inserts DNA segments up to 11,000 base pairs into the genome, enabling correction of thousands of mutations at once.
by Yue Gu, Traver Hart, Luis Leon-Novelo, John Paul Shen Advances in functional genomic technology, notably CRISPR using Cas9 or Cas12, now allow for large-scale double perturbati...
Gene editing represents one of the most transformative advances in modern medicine, offering the potential to correct genetic diseases at their source. However, a major obstacle in...
Using genome‑wide CRISPR activation and knockout screens in primary human T cells, researchers mapped the human genes that shape HIV infection and identified potent antiviral facto...
By applying base editing, scientists repaired a cystic fibrosis mutation that is unresponsive to current drugs in cell and organoid models, pointing to a possible treatment for som...
What’s most exciting about CRISPR is its potential to shift medicine from managing disease to directly correcting its root cause. End-to-end pipelines and regulatory advances aim t...
Scientists at UMass Chan Medical School have pioneered a groundbreaking gene editing technology named “prime assembly,” which challenges the limitations of traditional genome editi...
By adapting a retron-based editing system from E. coli to 15 bacterial species, scientists reveal a genome editing platform that could accelerate studies of pathogens, microbial in...
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