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In a landmark advancement that could redefine molecular diagnostics, researchers have unveiled a groundbreaking DNA-guided CRISPR–Cas12a system capable of programmable RNA recognit...
In a remarkable leap forward in gene editing technology, researchers at The Hong Kong University of Science and Technology (HKUST) have developed the world’s first DNA-guided CRISP...
In a groundbreaking development that could redefine antiviral therapy, researchers have engineered a CRISPR-Cas13d based system to combat hepatitis E virus (HEV) infection with rem...
The rapid evolution of CRISPR/Cas genome editing has redefined the possibilities of cellular and gene therapy, enabling precise correction, disruption, and regulation of disease-as...
Researchers have used modified CRISPR to silence the extra chromosome 21 in Down syndrome cells, showing promising preclinical results. The post Modified CRISPR tool targets Down s...
A newly characterized Cas12f nuclease shows strong editing in human cells. Researchers engineered a variant with markedly improved efficiency, advancing efforts toward compact geno...
New gene-editing techniques exploit unique chemical fingerprints in cancer DNA to selectively destroy tumor cells, paving the way for precision therapy.
In a groundbreaking advancement at the intersection of genome engineering and biocontainment, researchers at Seoul National University have developed a pioneering technology enabli...
New CRISPR tool shreds targeted cells instead of editing genes, showing promise for killing diseased cells while sparing healthy ones.
The CRISPR-Cas gene-editing system has long been the focus of research as a promising tool in genome editing. However, the emphasis has been on its underlying mechanisms and nuclea...
The platform, called ΨDNA, reprograms Cas12 nucleases to recognize and act on RNA using a DNA-based guide scaffold. In human cell lines, ΨDNA achieved 70–95% knockdown of endogenou...
Scientists have devised a CRISPR-based tool that can kill cells carrying a specific strand of RNA. The tested targets include cancerous and virus-infected cells [1]. Targeted assas...
Scientists at the Korea Advanced Institute of Science and Technology (KAIST), in collaboration with researchers at the University of California, Berkeley and the Gladstone Institut...
This week we dive into the Beyond Biotech archive to bring you a discussion with Dr Stanley Qi, the founder of Epicrispr. The post How Epicrispr is leveraging CRISPR without cutti...
Using genome‑wide CRISPR activation and knockout screens in primary human T cells, researchers mapped the human genes that shape HIV infection and identified potent antiviral facto...
A Phase I/II clinical trial shows that a stem cell transplant that removes CD33 from donor cells using CRISPR can prevent cancer recurrence. The post Acute Myeloid Leukemia Therapy...
Bacteria independently evolved similar RNA hairpin structures to fix a wasteful flaw in different CRISPR immune systems, revealing convergent evolution at work.
A biotech company is looking to get approval next after their recent discovery.
by Lisa H. Verzier, Eva Hesping, Marcel Doerflinger, Marco J. Herold, Justin A. Boddey Sporozoites of Plasmodium falciparum, the deadliest malaria parasite, are injected into the...
An AI system unearthed a trove of CRISPR-like proteins in minutes instead of weeks or months. The post MIT Mined Bacteria for the Next CRISPR—and Found Hundreds of Potential New To...
Scientists at UMass Chan Medical School have pioneered a groundbreaking gene editing technology named “prime assembly,” which challenges the limitations of traditional genome editi...
In the first of a new series of GEN Keynote Webinars, Professor Rodolphe Barrangou, PhD (North Carolina State; EIC, The CRISPR Journal) offers a front-row perspective of the CRISPR...
By adapting a retron-based editing system from E. coli to 15 bacterial species, scientists reveal a genome editing platform that could accelerate studies of pathogens, microbial in...
The CEO of Caszyme, a biotech company in Vilnius, Lithuania, presented details of Cas12l, a novel compact Cas nuclease with a variety of potential research and therapeutic applicat...
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