Programmable RNA Targeting via DNA-Guided CRISPR-Cas12a
In a landmark advancement that could redefine molecular diagnostics, researchers have unveiled a groundbreaking DNA-guided CRISPR–Cas12a system capable of programmable RNA recognit...
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In a landmark advancement that could redefine molecular diagnostics, researchers have unveiled a groundbreaking DNA-guided CRISPR–Cas12a system capable of programmable RNA recognit...
The CRISPR-Cas gene-editing system has long been the focus of research as a promising tool in genome editing. However, the emphasis has been on its underlying mechanisms and nuclea...
RNA sequencing advances support CRISPR-based detection methods that use kinetic signatures to identify multiple viruses and variants from RNA in a single, rapid diagnostic assay...
In a groundbreaking development that could redefine antiviral therapy, researchers have engineered a CRISPR-Cas13d based system to combat hepatitis E virus (HEV) infection with rem...
Scientists at the Korea Advanced Institute of Science and Technology (KAIST), in collaboration with researchers at the University of California, Berkeley and the Gladstone Institut...
The platform, called ΨDNA, reprograms Cas12 nucleases to recognize and act on RNA using a DNA-based guide scaffold. In human cell lines, ΨDNA achieved 70–95% knockdown of endogenou...
New CRISPR tool shreds targeted cells instead of editing genes, showing promise for killing diseased cells while sparing healthy ones.
by Lisa H. Verzier, Eva Hesping, Marcel Doerflinger, Marco J. Herold, Justin A. Boddey Sporozoites of Plasmodium falciparum, the deadliest malaria parasite, are injected into the...
Scientists have devised a CRISPR-based tool that can kill cells carrying a specific strand of RNA. The tested targets include cancerous and virus-infected cells [1]. Targeted assas...
In a remarkable leap forward in gene editing technology, researchers at The Hong Kong University of Science and Technology (HKUST) have developed the world’s first DNA-guided CRISP...
A newly characterized Cas12f nuclease shows strong editing in human cells. Researchers engineered a variant with markedly improved efficiency, advancing efforts toward compact geno...
The CEO of Caszyme, a biotech company in Vilnius, Lithuania, presented details of Cas12l, a novel compact Cas nuclease with a variety of potential research and therapeutic applicat...
In a groundbreaking advancement at the intersection of genome engineering and biocontainment, researchers at Seoul National University have developed a pioneering technology enabli...
New gene-editing techniques exploit unique chemical fingerprints in cancer DNA to selectively destroy tumor cells, paving the way for precision therapy.
TAP-seq combines genome editing with targeted RNA sequencing to enable sensitive and cost-effective single-cell functional genomics screens...
Researchers have used modified CRISPR to silence the extra chromosome 21 in Down syndrome cells, showing promising preclinical results. The post Modified CRISPR tool targets Down s...
The rapid evolution of CRISPR/Cas genome editing has redefined the possibilities of cellular and gene therapy, enabling precise correction, disruption, and regulation of disease-as...
Bacteria independently evolved similar RNA hairpin structures to fix a wasteful flaw in different CRISPR immune systems, revealing convergent evolution at work.
In a groundbreaking study recently published in Nature Communications, researchers have deployed CRISPR technology to revolutionize environmental detection of Burkholderia pseudoma...
A Phase I/II clinical trial shows that a stem cell transplant that removes CD33 from donor cells using CRISPR can prevent cancer recurrence. The post Acute Myeloid Leukemia Therapy...
RNA sequencing now enables simultaneous detection of multiple RNA modifications alongside gene expression, providing deeper...
This week we dive into the Beyond Biotech archive to bring you a discussion with Dr Stanley Qi, the founder of Epicrispr. The post How Epicrispr is leveraging CRISPR without cutti...
CIPHER‑seq is a single‑cell method that measures RNA and proteins simultaneously, exposing gaps in cytokine signaling and reducing mitochondrial stress signatures to give a clearer...
By applying base editing, scientists repaired a cystic fibrosis mutation that is unresponsive to current drugs in cell and organoid models, pointing to a possible treatment for som...
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