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The study identified "gene expression gradients", overlapping chemical signals that give every brain region a unique molecular ID.
RNA sequencing reveals subtle sex-linked differences in brain gene expression across cell types, offering insight into neurological and psychiatric disease risk and progression...
Biologists have long puzzled over why organisms with similar numbers of protein-coding genes can differ so dramatically in nervous system complexity. New research points to a poten...
In a groundbreaking study published in Nature Communications in 2026, researchers Gao, Gu, Ding, and colleagues have unveiled novel insights into the intricate relationship between...
A new study reveals how a single gene manages both brain communication and life-support systems through cellular "editing."
How does the brain time its own development? A new study explores histone bivalency—an epigenetic "red and green light" system that prevents premature neuron maturation and helps a...
A high-resolution study of 30 adult brains reveals over 3,000 genes with sex-biased expression. These findings link molecular sex differences to the prevalence of disorders like AD...
Researchers discovered that transposable elements (TEs) provided more than 20,000 regulatory binding sites that drive neural development. By acting as genomic couriers for transcri...
By developing IRISeq and EnrichSci, researchers can now map the spatial neighborhoods of millions of aging brain cells and zoom in on rare, vulnerable populations. Their discovery...
Advanced RNA sequencing methods, including IRISeq and EnrichSci, uncover spatial interactions and molecular changes linked to aging in vulnerable brain cell populations...
Changing glucose levels in the developing brain act as a metabolic switch, directing when progenitor cells divide or mature into myelin‑forming oligodendrocytes, with implications...
A cellular-resolution map of prenatal brain development in Down syndrome has been developed, revealing disrupted neuron production timing, altered cell types, and shared mechanisms...
A new “barcode” technique is unlocking the brain’s hidden wiring faster than ever. Scientists have created a new way to map how brain cells connect by assigning each neuron a uniqu...
by Anne K. Voss, Samantha Eccles, Johannes Wichmann, Waruni Abeysekera, Maria I. Bergamasco, Alexandra L. Garnham, Nishika Ranathunga, Yuqing Yang, Rory Bowden, Gordon K. Smyth, Ti...
A new study exposes a dynamic link between higher-order forebrain circuits and the activity-dependent regulation of Foxp2, a foundational gene heavily implicated in childhood aprax...
Is adult neuroplasticity merely brain development in disguise? A new study reveals that mature neurons do not invent new mechanisms to learn and remember; instead, they re-engage a...
Researchers mapped the histamine system in the brain, providing a new framework for understanding how this chemical system contributes to brain function, and potentially pointing t...
By the time researchers had catalogued 102 genes linked to autism in a single landmark paper five years ago, a quietly uncomfortable question had settled over the field. How could...
RNA sequencing readers may find related sequencing-based methods valuable for mapping neural circuits that shape vocal behavior and brain connectivity across species...
In a groundbreaking study that bridges the worlds of molecular neurobiology and psychiatry, researchers have uncovered compelling evidence linking hippocampal small RNAs derived fr...
RNA sequencing from more than 22 million cells trained a model that predicts cell-type-specific gene expression and noncoding variant...
by Mohita Gaur, Matthew J. Brooks, Xulong Liang, Ke Jiang, Anjani Kumari, Milton A. English, Paolo Cifani, Maria C. Panepinto, Jacob Nellissery, Robert N. Fariss, Laura Campello, C...
In a groundbreaking study that could redefine our understanding of brain cell development, researchers have unveiled a compelling link between glucose metabolism and the intricate...
A groundbreaking study published in Nature has revealed that subtle yet significant changes in brain structure and protein biomarkers can be detected long before the clinical diagn...
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