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Autophagy, which increases in younger mice under toxic stress, does not increase in older mice and leaves them susceptible to acute kidney injury (AKI). Increasing autophagic flux...
A new study highlights how a little-known protein, OTUB1, can reshape cell death pathways in hepatocellular carcinoma (HCC). Researchers report that OTUB1 acts as a brake on a part...
Glaucoma is a condition of progressive blindness driven by the death of retinal cells and degeneration of the optic nerve. It is driven by increased pressure in the aqueous humor,...
by Suman Saurav, Anuradha Jadon, Rajender K. Motiani Organelle turnover is fundamental to cellular homeostasis and regulates both physiological processes and pathological outcomes...
Scientists have engineered an enzyme that removes an advanced glycation end product (AGE) from proteins. This type of age-related modification, which affects protein function and c...
Every cell contains hundreds of mitochondria, the evolved descendants of what were once symbiotic bacteria. Much of the original mitochondrial DNA has migrated into the cell nucleu...
Senescent cells accumulate with age in tissues throughout the body. These cells cease replication and secrete a potent mix of pro-growth, pro-inflammatory signaling that is disrupt...
A molecular switch that helps the intestine manage incoming fat may have been identified in an unexpected place: the activity of a protein called TMEM135. In a study published in E...
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