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The Apolipoprotein E (APOE) gene exhibits a small number of common sequence variants across the human population, of which the desirable APOE2 variant is associated with modestly g...
Two amino acids. That is all that separates the APOE2 and APOE4 versions of the apolipoprotein E gene, a difference so small it seems almost irrelevant. Yet carriers of APOE2 are d...
The pro-Alzheimer’s allele APOE4 makes hippocampal neurons in mice smaller and hyperexcitable. This effect, which resembles epilepsy and accelerated aging, can be mitigated by mani...
The APOE4 gene triggers a protein called Nell2, which shrinks neurons and causes brain hyperactivity. Lowering Nell2 levels reversed these effects in mice, offering a new target fo...
The APOE ε4 variant heavily influences how toxic phosphorylated TDP-43 (pTDP-43) pathology migrates across the central nervous system.
Researchers discovered that the APOE2 gene variant shields the brain by helping neurons repair DNA damage and resist cellular senescence. By shifting focus from lipid transport to...
APOE4, we meet again.ScienceAlert stories are written, fact-checked, and edited by humans, never generated by AI. Don't miss a story, subscribe here.
Scientists have uncovered evidence that APOE2 may help brain cells better withstand stress and age-related damage, revealing a possible biological explanation for its protective ef...
The power of APOE2.ScienceAlert stories are written, fact-checked, and edited by humans, never generated by AI. Don't miss a story, subscribe here.
A new study suggests the APOE2 longevity gene may protect the brain from Alzheimer's by helping neurons repair DNA damage and resist cell aging.
A 10-year longitudinal study finds that diverse lifestyle activities in midlife are more powerful than the APOE ε4 gene in shaping cognitive health.
USC researchers have identified potential new drug compounds that may reduce the brain inflammation linked to Alzheimer’s disease, especially in people with the high-risk APOE4 gen...
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