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The Apolipoprotein E (APOE) gene exhibits a small number of common sequence variants across the human population, of which the desirable APOE2 variant is associated with modestly g...
The APOE ε4 variant heavily influences how toxic phosphorylated TDP-43 (pTDP-43) pathology migrates across the central nervous system.
A new study demonstrates that the protective benefits of lifestyle habits depend heavily on a person's exact genetic profile.
Scientists have uncovered an early brain mechanism that may help explain why people carrying the APOE4 gene face a higher risk of Alzheimer’s disease. For millions of people who ca...
The project uses artificial intelligence and small-molecule targeting to inhibit the cPLA2 enzyme, providing a novel pathway to shut down brain inflammation in high-risk APOE4 gene...
I remember the moment clearly. A hot July day, standing at my mailbox, opening an envelope from a genetic testing company. I expected reassurance. Instead, I saw a result sitting i...
Scientists have uncovered evidence that APOE2 may help brain cells better withstand stress and age-related damage, revealing a possible biological explanation for its protective ef...
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A new study suggests the APOE2 longevity gene may protect the brain from Alzheimer's by helping neurons repair DNA damage and resist cell aging.
An interdisciplinary team of researchers at the University of Southern California’s Center for Personalized Brain Health (CPBH) has embarked on a groundbreaking investigation targe...
USC researchers have identified potential new drug compounds that may reduce the brain inflammation linked to Alzheimer’s disease, especially in people with the high-risk APOE4 gen...
Specific variants of the AQP4 gene interact synergistically with poor sleep habits to accelerate grey matter loss and alter cognitive function.
The analysis reveals that asymptomatic individuals presenting with very high baseline p-tau217 concentrations face an absolute 38% risk of developing cognitive impairment within 5...
According to a new study, a special protein disposal system, currently found only in neurons, is linked to central hallmarks of Alzheimer’s disease [1]. The membranal proteasome Al...
A blood test may predict if apparently healthy older adults are likely to develop Alzheimer’s symptoms in the next five or 10 years, researchers reported.
A new study reveals that amyloid precursor protein (APP), long studied merely as the source of toxic plaques in Alzheimer's disease, serves a vital protective role as a cellular gu...
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