Search results for Causal Transcriptomics

Parse Biosciences and bit.bio Announce Landmark Alliance

This Parse Biosciences and bit.bio alliance combines single-cell RNA sequencing and causal transcriptomics to map transcription factor-driven cell identity, enabling improved disea...

Transcriptomics in space, an RNA sequencing pipeline for space biology research

RNA sequencing supports space biology research by enabling transcriptome-wide analysis of gene expression changes associated with spaceflight and adaptation to space environments.....

Non-destructive transcriptomics via vesicular export

RNA sequencing with NTVE enables repeated monitoring of gene expression in living cells, supporting time-course analysis of differentiation, perturbation responses, and cellular dy...

Unveiling gene perturbation effects through gene regulatory networks inference from single-cell transcriptomic data

by Clelia Corridori, Merrit Romeike, Giorgio Nicoletti, Christa Buecker, Samir Suweis, Sandro Azaele, Graziano Martello Physiological and pathological processes are governed by ne...

The history of spatial transcriptomics at Sanger

At the Wellcome Sanger Institute, advances in spatial transcriptomics and RNA sequencing enable detailed mapping of gene expression and cellular interactions within complex tissues...

CAMP4 Therapeutics preprints pioneering study on regulatory RNA profiling and gene upregulation

RNA sequencing with regRNA Capture-seq identified thousands of regulatory RNAs and enabled new strategies to increase expression of disease-related genes using ASOs...

SPTEdU-seq – parallel optics-free newborn cell tracking and spatial total transcriptional dynamics

RNA sequencing combined with spatial profiling tracks gene expression and cell proliferation, revealing dynamic cellular interactions and uncovering new insights into development.....

mFABIO: An integrative multi-tissue TWAS fine-mapping approach to prioritize potentially causal genes and tissues underl...

by Haihan Zhang, Kevin He, Lam C. Tsoi, Xiang Zhou Recent advances in transcriptome-wide association study (TWAS) fine-mapping have enabled the joint modeling of multiple genes to...

Single-cell total RNA sequencing expands our view of gene regulation

RNA sequencing captures both coding and noncoding RNAs at single-cell resolution, revealing complex regulatory programs and cellular identities across development and disease...

The differentiation of myeloid progenitors is effected by cascading waves of coordinated gene expression that remodel ce...

by Andrea Repele, Joanna Handzlik, Nimasha Samarawickrama, Trevor Long, Sunil Nooti, Veena Potluri, Yen Lee Loh, Manu The differentiation of hematopoietic progenitors into special...

In vivo RNA sequencing reveals real-time immune response to infection

RNA sequencing of newly synthesized transcripts reveals dynamic immune cell activation and gene regulation during infection, providing real-time insight into how immune responses a...

A long-read RNA sequencing and polysome profiling framework reveals transposable element-driven transcript diversity

RNA sequencing reveals how transposable elements drive alternative splicing and alter translation in glioblastoma, generating diverse RNA isoforms linked to cancer progression...

73 PROSPECTIVE WHOLE TRANSCRIPTOME SEQUENCING OF BILE DUCT STRICTURES: A MULTI-OMIC APPROACH TO DISTINGUISH BENIGN FROM...

RNA sequencing without references uncovers hidden transcriptome features

RNA sequencing using reference-free analysis uncovers novel transcripts and hidden gene features, expanding discovery beyond traditional genome-based approaches...

Tu1666 IMMUNE EXPRESSION PHENOTYPES AND FIBROSIS SEVERITY IN ACHALASIA ESOPHAGUS: AN UNBIASED TRANSCRIPTOMIC ANALYSIS

Decima predicts gene expression at single-cell resolution

RNA sequencing from more than 22 million cells trained a model that predicts cell-type-specific gene expression and noncoding variant...

From microRNA discovery to molecular mechanisms: building robust miRNA workflows for cancer research

Integrated miRNA workflows connect sequencing, dPCR validation, and pathway analysis to improve cancer biomarker discovery and biological interpretation from challenging samples li...

TAP-seq – targeted single-cell RNA and perturbation sequencing

TAP-seq combines genome editing with targeted RNA sequencing to enable sensitive and cost-effective single-cell functional genomics screens...

New sequencing method exposes hidden gaps in immune signaling

RNA sequencing combined with protein analysis enables detailed tracking of immune cell activity, revealing cytokine dynamics and improving understanding of cancer and immune respon...

Multiple Sclerosis Myelin Loss Revealed by Transcriptomic Analysis in Mice

A new study compares two prevailing models, cuprizone (CPZ) and lysophosphatidylcholine (LPC), to reveal new insights into myelin loss and regeneration in a MS mouse model.  The po...

Takara Bio USA, Inc. validates new class of spatial transcriptomics technology with benchmark study for cancer research

Takara Bio’s Trekker FX spatial transcriptomics improves single-cell resolution and detects more cell interactions, enhancing analysis of tumor microenvironments in cancer samples....

Scientists use RNA sequencing to identify trigger of Crohn’s disease bowel scarring

RNA sequencing reveals interactions between immune and endothelial cells that drive fibrosis in Crohn’s disease, identifying new pathways that could guide targeted therapies...

MR2G: A novel framework for causal network inference using GWAS summary data

by Zhaotong Lin, Wei Pan, Haoran Xue Inferring a causal network among multiple traits is essential for unraveling complex biological relationships and informing interventions. Men...

New Single‑Cell Platform Tracks RNA and Protein in Immune Signaling

CIPHER‑seq is a single‑cell method that measures RNA and proteins simultaneously, exposing gaps in cytokine signaling and reducing mitochondrial stress signatures to give a clearer...