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In a groundbreaking study poised to redefine our understanding of neurodegenerative diseases, researchers have uncovered compelling evidence linking the expression of caspase-4 wit...
An experimental gene therapy called SynCav1 can protect the central nervous system from the cognitive decline linked to TDP-43-related proteinopathy, a primary driver of FTD, ALS,...
The APOE ε4 variant heavily influences how toxic phosphorylated TDP-43 (pTDP-43) pathology migrates across the central nervous system.
Gerstmann-Sträussler-Scheinker disease (GSS) is characterized by an autosomal dominant inheritance due to mutations in the prion protein gene (PRNP) [1,2]. GSS(P105L) is a rare var...
In the sacral spinal cord of a patient with amyotrophic lateral sclerosis, something strange holds on. Surrounding motor neurons are dying, their interiors a mess of misfolded prot...
The tau protein is involved in maintaining stability of microtubule structures in the axons that connect neurons. It isn't the only protein that undertakes this task, and loss of f...
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