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rna-seqblog.com /1 month ago

A long-read RNA sequencing and polysome profiling framework reveals transposable element-driven transcript diversity

RNA sequencing reveals how transposable elements drive alternative splicing and alter translation in glioblastoma, generating diverse RNA isoforms linked to cancer progression...

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rna-seqblog.com /1 week ago

HELIX – a scalable model for predicting context-dependent regulation of RNA splicing and isoform usage

RNA sequencing combined with deep learning enabled HELIX to predict tissue-specific splicing patterns, transcript isoforms, and patient-specific splicing changes in cancer...

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rna-seqblog.com /2 weeks ago

FUSILLI -long-read fusion detection

RNA sequencing with FUSILLI improves detection of leukemia fusion oncogenes, supporting more accurate molecular diagnosis and subtyping in pediatric B-cell acute lymphoblastic leuk...

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rna-seqblog.com /1 month ago

CHOP researchers develop versatile and low-cost technology for targeted long-read RNA sequencing

Long-read RNA sequencing improves rare disease diagnosis by resolving transcript isoforms and variant effects, enabling more accurate interpretation of pathogenic splicing...

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rna-seqblog.com /1 month ago

RNA sequencing method maps RNA binding proteins with higher precision

RNA sequencing enables precise mapping of RNA binding protein targets, improving detection of low-abundance interactions and advancing understanding of gene regulation...

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genengnews.com /1 week ago

HELIX AI Model Accurately Predicts RNA Splicing, Unlocks Precision Medicine

A new AI-driven framework enables highly accurate prediction of RNA splicing and isoform usage for applications across splicing pathogenic variant interpretation and precision medi...

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rna-seqblog.com /1 month ago

longcallR – SNP calling, haplotype phasing and allele-specific analysis with long RNA-seq reads

RNA sequencing with long-read technology links genetic variants to transcript structure, uncovering allele-specific splicing and previously unannotated RNA events across human samp...

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rna-seqblog.com /1 month ago

The history of spatial transcriptomics at Sanger

At the Wellcome Sanger Institute, advances in spatial transcriptomics and RNA sequencing enable detailed mapping of gene expression and cellular interactions within complex tissues...

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neurosciencenews.com /2 weeks ago

Mapping Millions of Aging Brain Cells Simultaneously

By developing IRISeq and EnrichSci, researchers can now map the spatial neighborhoods of millions of aging brain cells and zoom in on rare, vulnerable populations. Their discovery...

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rna-seqblog.com /1 month ago

SPTEdU-seq – parallel optics-free newborn cell tracking and spatial total transcriptional dynamics

RNA sequencing combined with spatial profiling tracks gene expression and cell proliferation, revealing dynamic cellular interactions and uncovering new insights into development.....

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bioengineer.org /6 days ago

RBM20 Isoform Control Shapes Splicing in Health

In the intricate landscape of genetic regulation, the study of RNA-binding proteins is unraveling new dimensions of molecular control mechanisms pivotal for development and disease...

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journals.plos.org /1 month ago

STARCall integrates image stitching, alignment, and read calling to enable scalable analysis of <i>in situ</i&g...

by Nicholas J. Bradley, Sriram Pendyala, Katie Partington, Douglas M. Fowler Fluorescent in situ sequencing involves imaging-based sequencing by synthesis in intact cells or tissu...

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