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rna-seqblog.com /1 month ago

HELIX – a scalable model for predicting context-dependent regulation of RNA splicing and isoform usage

RNA sequencing combined with deep learning enabled HELIX to predict tissue-specific splicing patterns, transcript isoforms, and patient-specific splicing changes in cancer...

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rna-seqblog.com /2 weeks ago

Combining AI and RNA analysis improves detection of disease-causing splicing variants

Combining computational tools with functional RNA sequencing improves interpretation of disease-causing splicing variants and highlights the importance of transcript-level validati...

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journals.plos.org /2 weeks ago

Splicing deficiency is driven by genomic erosion in non-recombining algal mating-type chromosomes

by Chris Condon, Andrea Galvez, Alexander Kramer, Landen Gozashti, Chris Vollmers, Manuel Ares Jr., Russell Corbett-Detig Splicing deficiency may represent a critical yet underexp...

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rna-seqblog.com /1 month ago

Generative modeling for RNA splicing prediction and design

Combining RNA sequencing data with generative AI, TrASPr+BOS predicts and designs tissue-specific splicing outcomes, helping researchers explore gene regulation and potential RNA t...

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genengnews.com /1 month ago

HELIX AI Model Accurately Predicts RNA Splicing, Unlocks Precision Medicine

A new AI-driven framework enables highly accurate prediction of RNA splicing and isoform usage for applications across splicing pathogenic variant interpretation and precision medi...

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rna-seqblog.com /1 month ago

Long-read RNA sequencing reveals how alternative splicing shapes immune responses

Long-read RNA sequencing revealed extensive alternative splicing changes in activated human monocytes, uncovering functional isoforms that enhance immune protein production during...

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journals.plos.org /2 weeks ago

Unusual decay: Recombination loss leads to splicing errors in green algae

by Anamaria Necsulea Recombination suppression leads to genomic erosion through an accumulation of deleterious mutations. A new study in PLOS Biology reveals an outstanding increa...

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rna-seqblog.com /3 weeks ago

EclipseBio expands eCOMPASSâ„¢ platform with eSENSE Breakâ„¢ to map RNA fragmentation at nucleotide resolution

Eclipse Bioinnovations uses RNA sequencing in eSENSE Breakâ„¢ to map RNA fragmentation at single-nucleotide resolution, helping developers understand RNA stability and structural v...

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journals.plos.org /1 month ago

IsoPepTracker: An interactive web application for peptide-driven isoform analysis

by Araf Mahmud, Chen Huang Alternative splicing affects 95% of multi-exon genes, generating protein isoforms with distinct functions. While current alternative splicing analyses e...

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rna-seqblog.com /1 month ago

Perturb-DBiT – mapping cancer biology with spatial CRISPR screening and RNA sequencing

New spatial RNA sequencing technology links large-scale CRISPR perturbations to tumor growth, metastasis, immune responses, and complex RNA regulation within intact tissues... The...

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bioengineer.org /1 month ago

Precise Gene Control Using FDA-Approved RNA Splicing Drug

In a groundbreaking advance poised to reshape gene therapy and molecular medicine, researchers have unveiled a novel strategy for precise gene regulation via RNA splicing modulatio...

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bioengineer.org /1 month ago

RBM20 Isoform Control Shapes Splicing in Health

In the intricate landscape of genetic regulation, the study of RNA-binding proteins is unraveling new dimensions of molecular control mechanisms pivotal for development and disease...

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rna-seqblog.com /1 month ago

m6A-ARTR-DBiT – mapping RNA modifications across tissues with spatial m6A profiling

Spatial RNA sequencing and m6A profiling reveal how RNA modifications vary across tissues, uncovering region-specific patterns of gene regulation in developing and adult... The pos...

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genengnews.com /1 month ago

Immune Response Activated by RNA Splicing Opens Targeted Therapies

Researchers have uncovered a previously underappreciated mechanism, where RNA splicing plays a central role in shaping immune response. The results provide insights into immune-med...

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rna-seqblog.com /2 weeks ago

Nanopore direct RNA sequencing expands the view of the transcriptome

RNA sequencing using nanopore direct RNA sequencing enables simultaneous analysis of native RNA molecules, transcript isoforms, RNA modifications, and poly(A) tails for comprehensi...

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