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rna-seqblog.com /1 month ago

longcallR – SNP calling, haplotype phasing and allele-specific analysis with long RNA-seq reads

RNA sequencing with long-read technology links genetic variants to transcript structure, uncovering allele-specific splicing and previously unannotated RNA events across human samp...

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journals.plos.org /1 month ago

Semi-parametric empirical bayes method for multiplet detection in snATAC-seq with probabilistic multi-omic integration

by Yuntian Wu, Haoran Hu, Wei Chen, Johann E. Gudjonsson, Lam C. Tsoi, Xiaoquan Wen Multiplets arise when multiple cells are captured within the same droplet during single-cell se...

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rna-seqblog.com /1 month ago

Children’s Hospital of Philadelphia researchers develop new RNA sequencing platform for diagnosing rare diseases

RNA sequencing using targeted long-read approaches enables detection of disease-causing variants by revealing how genetic changes disrupt full-length RNA molecules...

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journals.plos.org /2 days ago

TIPP-SD: A new method for species detection in microbiomes

by Chengze Shen, Eleanor Wedell, Mihai Pop, Tandy Warnow In this study, we present TIPP-SD (i.e., TIPP for Species Detection), a new technique for species detection in a microbiom...

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rna-seqblog.com /3 weeks ago

Benchmarking nanopore RNA sequencing for m6A detection

RNA sequencing with nanopore technology improves m6A modification mapping when paired with calibrated workflows, helping reveal cell-specific RNA regulation in fibroblasts and neur...

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rna-seqblog.com /1 month ago

Programmable RNA detection enables multiplex virus identification

RNA sequencing advances support CRISPR-based detection methods that use kinetic signatures to identify multiple viruses and variants from RNA in a single, rapid diagnostic assay...

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scotsman.com /3 weeks ago

SNP to fall short of overall majority at Holyrood election, poll finds

The Norstat survey for The Sunday Times suggested the Nationalists would secure 57 MSPs

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journals.plos.org /1 month ago

STARCall integrates image stitching, alignment, and read calling to enable scalable analysis of <i>in situ</i&g...

by Nicholas J. Bradley, Sriram Pendyala, Katie Partington, Douglas M. Fowler Fluorescent in situ sequencing involves imaging-based sequencing by synthesis in intact cells or tissu...

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scotsman.com /3 weeks ago

SNP well short of majority but to remain largest party by far, says leading pollster

The survey by Diffley Partnership had the Nationalists on 56 seats - nine short of a majority.

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rna-seqblog.com /1 month ago

Alida Biosciences launches EpiPlexÂ® Tri-Modâ„¢ service for simultaneous profiling of three key mRNA modifications

RNA sequencing now enables simultaneous detection of multiple RNA modifications alongside gene expression, providing deeper...

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rna-seqblog.com /3 weeks ago

Systematic assessment of diverse RNA modifications using nanopore direct RNA sequencing

RNA sequencing with nanopore technology reveals how diverse therapeutic RNA modifications affect signal detection, helping define current capabilities and limitations for modificat...

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bbc.com /3 weeks ago

SNP wins Scottish election as Reform and Labour tie for second

John Swinney's party finished comfortably ahead of its rivals, but short of an overall majority.

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rna-seqblog.com /3 weeks ago

SCOTCH – isoform-level characterization of gene expression through long-read single-cell RNA sequencing

RNA sequencing with SCOTCH improves isoform-level analysis from long-read single-cell data, helping reveal cell-type-specific transcript diversity and novel RNA isoforms

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bioengineer.org /1 month ago

SNPs in FILIP1-SENP6, FTO Linked to TMJ Osteoarthritis

In a pioneering advancement that could reshape our understanding of temporomandibular joint osteoarthritis (TMJ OA), a new study delves deeply into the genetic underpinnings of thi...

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bioengineer.org /4 weeks ago

Programmable RNA Targeting via DNA-Guided CRISPR-Cas12a

In a landmark advancement that could redefine molecular diagnostics, researchers have unveiled a groundbreaking DNA-guided CRISPR–Cas12a system capable of programmable RNA recognit...

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scotsman.com /1 month ago

SNP three short of majority with Reform in second, poll finds

The SNP is set to win 62 MSPs, with Reform on 19 and Labour on 17.

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journals.plos.org /3 weeks ago

Targeted sequencing enhances detection of pangolin trafficking hotspots and dynamics of both domestic and global trade m...

by Sean P. Heighton, Jérôme Murienne, Mukesh Thakur, Alain Didier Missoup, Wirdateti Wirdateti, Chabi Sylvestre Djagoun, Sery Bi Gonedelé, Gabriel Ngua Ayecaba, Brice Roxan Momboua...

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rna-seqblog.com /2 weeks ago

Small change in RNA, big impact on innate immunity

RNA sequencing and protein interaction analyses reveal how a single nucleotide at the start of RNA can alter antiviral immune signaling and influence therapeutic RNA design...

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rna-seqblog.com /1 week ago

HELIX – a scalable model for predicting context-dependent regulation of RNA splicing and isoform usage

RNA sequencing combined with deep learning enabled HELIX to predict tissue-specific splicing patterns, transcript isoforms, and patient-specific splicing changes in cancer...

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rte.ie /3 weeks ago

SNP to emerge as largest party in Scottish parliament

Scottish National Party leader John Swinney has said he is "certain" the SNP will emerge as the largest party in Holyrood as his Scottish Labour rival Anas Sarwar effectively conce...

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rna-seqblog.com /2 weeks ago

A*STAR scientists develop new method to reveal how RNA structure influences health and disease

RNA sequencing with the new sm-PORE-cupine method reveals how individual RNA molecules fold and behave, offering insights into gene regulation, viral biology, and therapeutic disco...

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journals.plos.org /3 weeks ago

Partial domain adaptation enables cross domain cell type annotation between scRNA-seq and snRNA-seq

by Xiran Chen, Quan Zou, Qinyu Cai, Xiaofeng Chen, Weikai Li, Yansu Wang Accurate cell type annotation across datasets is a key challenge in single-cell analysis. snRNA-seq enable...

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rna-seqblog.com /1 month ago

CHOP researchers develop versatile and low-cost technology for targeted long-read RNA sequencing

Long-read RNA sequencing improves rare disease diagnosis by resolving transcript isoforms and variant effects, enabling more accurate interpretation of pathogenic splicing...

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bbc.com /3 weeks ago

SNP dominates west of Scotland as Labour struggles in heartlands

The SNP sweeps to victory throughout much of Glasgow, Ayrshire, Lanarkshire and Renfrewshire.

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