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journals.plos.org /1 month ago

Characterization of METTL3/14-mediated m6A modification in human transcriptome using Nanopore dir...

by Emily Kurtyan, Andrew J. Stein, Kelly J. Abdalla, Zhangerjiao Yuan, Miten Jain, Fadia Ibrahim Post-transcriptional RNA modifications modulate diverse aspects of RNA metabolism....

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rna-seqblog.com /2 weeks ago

Nanopore direct RNA sequencing reveals the challenges of detecting RNA modifications

Direct RNA sequencing with Oxford Nanopore technology enables detection of RNA modifications, but benchmarking reveals substantial differences in accuracy among current computation...

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rna-seqblog.com /1 month ago

Avoiding a sticky situation: how cells stop messenger RNAs from clumping together

RNA sequencing reveals how naturally occurring mRNA sequences may reduce harmful RNA aggregation, offering insights into transcriptome stability and the design of mRNA therapeutics...

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journals.plos.org /1 month ago

METTL1-mediated m7G modification regulates hair follicle cycle via the HOXC13/FOXN1/DSG4 axis

by Xinyan Gan, Qiwen Li, Qiuchan Xiong, Denghao Huang, Zizheng Liu, Qi Yin, Shuang Jiang, Takuma Matsubara, Shoichiro Kokabu, Wei Yan, Quan Yuan Rapid hair follicle cycling requir...

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rna-seqblog.com /1 month ago

Detection and sequencing of Ap2N-capped RNAs in human cells

RNA sequencing identifies newly characterized Ap2N caps on human RNAs, including tRNA-derived fragments, revealing additional complexity in RNA processing and responses to oxidativ...

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genengnews.com /2 weeks ago

The Epitranscriptome Heads Toward Clinical Necessity

Short-read RNA sequencing reporting the modifications that alter protein output is starting to make epitranscriptomics indispensable for patient selection in precision medicines. T...

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journals.plos.org /1 month ago

Post-transcriptional regulation of Profilin-2 by microRNAs and RNA-binding proteins forms a critical regulatory node for...

by Carolyn Sangokoya, Isabella R. Rosso, Rana Ghandehari-Alavijeh, Robert Blelloch Post-transcriptional control by RNA binding proteins (RBPs) and microRNAs play central roles in...

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journals.plos.org /4 weeks ago

Role of the m6A methyltransferase Mettl16 in Drosophila development

by Penghui Song, Lijuan Ma, Dong Yan N6-methyladenosine (m6A), one of the most abundant chemical modifications on RNA, is installed by METTL3 and several other methyltransferases,...

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nanowerk.com /1 week ago

Scientists identify how to prevent protein production errors in mRNA vaccines

Scientists discover why ribosomes misread certain modified mRNA sequences and show how simple sequence changes could improve vaccine design and safety.

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rna-seqblog.com /4 weeks ago

RNA variant imaging for cancer diagnosis

RNA Variant Imaging is attracting attention because it addresses a persistent blind spot in cancer diagnostics: many clinically relevant RNA isoforms, splice events, and fusion tra...

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rna-seqblog.com /1 month ago

Short-read RNA-seq yields lower estimates of A-to-I RNA editing levels than long-read cDNA sequencing

RNA sequencing comparisons show that short reads can underestimate A-to-I RNA editing, while long-read sequencing provides more accurate measurements through improved genomic align...

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rna-seqblog.com /3 weeks ago

Long-read RNA sequencing reveals how neurons choose alternative RNA endings

Long-read RNA sequencing and APALORD reveal how alternative polyadenylation changes during neuronal differentiation and identify new patterns of RNA processing across species...

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rna-seqblog.com /1 month ago

Small RNA sequencing reveals regulatory roles for sdRNAs in acute myeloid leukemia

Small RNA sequencing reveals cell-specific sdRNA patterns in AML and healthy hematopoiesis, linking certain snoRNA-derived RNAs to gene regulation and poorer patient outcomes...

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rna-seqblog.com /1 month ago

RNA sequencing reveals functional chimeric mRNAs in mammalian immunity

Direct RNA sequencing revealed thousands of chimeric mRNAs in mammalian cells, uncovering previously unknown proteins with roles in immunity, inflammation, and potential drug disco...

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rna-seqblog.com /4 weeks ago

Villanova biology professor awarded NIH grant to advance understanding of RNA decay

RNA sequencing will help Villanova researchers investigate how UPF1 controls nonsense-mediated RNA decay and how cells identify defective RNAs linked to genetic disease...

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bioengineer.org /1 month ago

RAS Rewires Ribosomes, Reshaping How Cells Read the Genetic Code

Cancer cells may be able to reprogram more than gene activity and signaling networks. A study led by researchers at Fudan University and Zhongshan Hospital in Shanghai reports that...

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rna-seqblog.com /3 weeks ago

The Human RNome Project Consortium seeks to publish first-ever complete sequence of the bodyÐ²Ð‚â„¢s RNA

RNA sequencing efforts from the Human RNome Project aim to build a comprehensive reference of human RNA sequences, isoforms, processing states and chemical modifications...

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rna-seqblog.com /1 month ago

qMAP reveals RNA fragmentation patterns linked to development and disease

RNA sequencing combined with qMAP reveals regulatory RNA fragmentation patterns associated with cell reprogramming, ulcerative colitis, implantation failure, and aging...

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rna-seqblog.com /1 month ago

A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction

RNA sequencing reveals that calorie restriction drives dose-responsive alternative splicing across multiple tissues, affecting mitochondrial, translational, and RNA quality-control...

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scitechdaily.com /3 weeks ago

A New RNA Strategy Could Target Thousands of Genetic Disorders

This new approach targets disorders including cystic fibrosis, muscular dystrophy, and some cancers. In lab-grown tissue from a cystic fibrosis patient who did not respond to exist...

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rna-seqblog.com /1 week ago

RiboBA improves detection of hidden protein-coding regions using ribosome profiling

RiboBA improves ribosome profiling and RNA sequencing analysis by correcting experimental biases, enabling more accurate identification of hidden protein-coding regions and transla...

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genengnews.com /3 weeks ago

Viral Protein Helps Self-Amplifying RNA Overcome Cellular Defenses

Adding a viral protein, NoV B2, helped self-amplifying RNA overcome cellular defenses and produce more target protein without diminishing immune stimulation, potentially enabling f...

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rna-seqblog.com /1 month ago

Spatial mapping of RNA turnover kinetics in the mouse brain

Spatial RNA sequencing maps RNA synthesis and degradation across the mouse brain, revealing how different regions rapidly adjust gene expression in response to stimulation...

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bioengineer.org /1 month ago

Methylation puts parasites in motion

StackRSS Canonical Source Context Original Article Title: Methylation puts parasites in motion Journal or Source Feed: Eurekalert | Biology Original Publication Date: Not provided...

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