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In a groundbreaking advancement for synthetic mRNA therapeutics, recent research unveils how the chemical nature of nucleotide modifications profoundly influences ribosome behavior...
..Nanopore RNA sequencing models can detect RNA modifications, but benchmark results reveal significant false positives and highlight the importance of controls for accurate epitra...
Nanopore direct RNA sequencing enables accurate, site-specific quantification of pseudouridine modifications in human ribosomal RNA, expanding opportunities for large-scale epitran...
RNA sequencing continues to reveal unexpected RNA functions, including how mRNA 3′UTRs help regulatory proteins fold correctly and maintain proper cellular activity... The post MSK...
RNA sequencing with QutRNA2 enables faster, more accurate detection of transfer RNA modifications from direct Nanopore sequencing, supporting large scale studies of RNA biology...
RNA sequencing with regRNA Capture-seq identified thousands of regulatory RNAs and enabled new strategies to increase expression of disease-related genes using ASOs...
In the intricate landscape of genetic regulation, the study of RNA-binding proteins is unraveling new dimensions of molecular control mechanisms pivotal for development and disease...
Spatial RNA sequencing and m6A profiling reveal how RNA modifications vary across tissues, uncovering region-specific patterns of gene regulation in developing and adult... The pos...
by Md Istiaq Ansari, Khandakar Tanvir Ahmed, Debby D. Wang, Kirill Medvedev, Wei Zhang Protein isoforms produced from the same gene through post-transcriptional regulatory mechani...
RNA sequencing reveals that RBM20 uses multiple transcription start sites, producing distinct protein isoforms that influence heart development, cardiomyopathy, and heart muscle fu...
While 3' UTRs have traditionally been dismissed as key regulators, a new study shows that these highly conserved mRNA tails facilitate the folding of intrinsically disordered prote...
RNA sequencing combined with high-throughput functional profiling enabled researchers to build complete riboswitch models and uncover coordinated structural changes involved in gen...
by Chengchao Ding, Xinyi Ashley Liu, Fushun Zhang, Saori Uematsu, Shu-Bing Qian, Yan Xiang Schlafens proteins (SLFNs) are interferon-inducible regulators of RNA metabolism that in...
A newly engineered ribozyme repairs broken RNA, creating new opportunities for studying RNA evolution while improving the detection of damaged molecules through RNA sequencing...
by Alejandro Vasquez-Rifo, Denis Susorov, Emily H. Sholi, Gabriel Demo, Yasaman Jami, Jihui Sha, James A. Wohlschlegel, Andrei Korostelev, Victor Ambros Pseudomonas aeruginosa emp...
In a groundbreaking advance poised to reshape gene therapy and molecular medicine, researchers have unveiled a novel strategy for precise gene regulation via RNA splicing modulatio...
RNA sequencing using nanopore direct RNA sequencing enables simultaneous analysis of native RNA molecules, transcript isoforms, RNA modifications, and poly(A) tails for comprehensi...
In a groundbreaking revelation that promises to reshape our understanding of gene regulation, scientists have decrypted the elusive structural dynamics of the RNA-induced silencing...
RNA sequencing and new computational tools enabled construction of a large RNA interactome atlas linking RNA-binding proteins, RNA interactions, and gene regulation...
Biochemistry is enormously complex. The closer that researchers look, the more that they will find. Details remain incompletely mapped and understood at every level; there are only...
by Connor R. King, Casey-Tyler Berezin, Brian Munsky, Jean Peccoud Nonsegmented negative-strand RNA viruses (NNSV) are a diverse class of medically relevant viruses which display...
Researchers have discovered a primate-specific piece of non-coding RNA that is linked to aging and makes senescence worse. The packing matters While non-coding RNA strands (ncRNAs)...
In a groundbreaking advance poised to reshape the landscape of RNA therapeutics, researchers have engineered a novel drug-responsive replication machinery capable of exerting exqui...
A new study introduces an innovative platform capable of accurately sizing the toxic repeat expansion mutations that drive muscular dystrophy, Huntington’s disease, and ALS.
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