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RNA sequencing continues to reveal unexpected RNA functions, including how mRNA 3′UTRs help regulatory proteins fold correctly and maintain proper cellular activity... The post MSK...
In a groundbreaking advancement for synthetic mRNA therapeutics, recent research unveils how the chemical nature of nucleotide modifications profoundly influences ribosome behavior...
RNA sequencing and new computational tools enabled construction of a large RNA interactome atlas linking RNA-binding proteins, RNA interactions, and gene regulation...
..Nanopore RNA sequencing models can detect RNA modifications, but benchmark results reveal significant false positives and highlight the importance of controls for accurate epitra...
In a groundbreaking advance poised to reshape the landscape of RNA therapeutics, researchers have engineered a novel drug-responsive replication machinery capable of exerting exqui...
In a groundbreaking revelation that promises to reshape our understanding of gene regulation, scientists have decrypted the elusive structural dynamics of the RNA-induced silencing...
A newly engineered ribozyme repairs broken RNA, creating new opportunities for studying RNA evolution while improving the detection of damaged molecules through RNA sequencing...
In the intricate landscape of genetic regulation, the study of RNA-binding proteins is unraveling new dimensions of molecular control mechanisms pivotal for development and disease...
RNA sequencing with regRNA Capture-seq identified thousands of regulatory RNAs and enabled new strategies to increase expression of disease-related genes using ASOs...
RNA sequencing reveals that RBM20 uses multiple transcription start sites, producing distinct protein isoforms that influence heart development, cardiomyopathy, and heart muscle fu...
Nanopore direct RNA sequencing enables accurate, site-specific quantification of pseudouridine modifications in human ribosomal RNA, expanding opportunities for large-scale epitran...
Spatial RNA sequencing and m6A profiling reveal how RNA modifications vary across tissues, uncovering region-specific patterns of gene regulation in developing and adult... The pos...
In a groundbreaking advance poised to reshape gene therapy and molecular medicine, researchers have unveiled a novel strategy for precise gene regulation via RNA splicing modulatio...
RNA sequencing combined with transformer based artificial intelligence improves prediction of microRNA binding sites, helping researchers better understand gene regulation and RNA...
While 3' UTRs have traditionally been dismissed as key regulators, a new study shows that these highly conserved mRNA tails facilitate the folding of intrinsically disordered prote...
RNA sequencing combined with high-throughput functional profiling enabled researchers to build complete riboswitch models and uncover coordinated structural changes involved in gen...
Researchers have uncovered a previously underappreciated mechanism, where RNA splicing plays a central role in shaping immune response. The results provide insights into immune-med...
This GEN Spotlight on RNA Therapeutics brings you three interlinked sessions that feature outstanding researchers exploring various aspects of RNA biology and therapeutics. The pos...
A new study introduces an innovative platform capable of accurately sizing the toxic repeat expansion mutations that drive muscular dystrophy, Huntington’s disease, and ALS.
by Md Istiaq Ansari, Khandakar Tanvir Ahmed, Debby D. Wang, Kirill Medvedev, Wei Zhang Protein isoforms produced from the same gene through post-transcriptional regulatory mechani...
RNA sequencing with QutRNA2 enables faster, more accurate detection of transfer RNA modifications from direct Nanopore sequencing, supporting large scale studies of RNA biology...
Researchers have discovered a primate-specific piece of non-coding RNA that is linked to aging and makes senescence worse. The packing matters While non-coding RNA strands (ncRNAs)...
New England Biolabs introduces a new RNA sequencing companion module that simplifies direct native RNA sequencing with Oxford Nanopore for transcriptomics and RNA...
by Alejandro Vasquez-Rifo, Denis Susorov, Emily H. Sholi, Gabriel Demo, Yasaman Jami, Jihui Sha, James A. Wohlschlegel, Andrei Korostelev, Victor Ambros Pseudomonas aeruginosa emp...
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