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rna-seqblog.com /1 month ago

Parse biosciences launches FFPE-compatible barcoding technology for whole transcriptome single cell analysis

Parse Biosciences enables RNA sequencing of FFPE samples at single cell resolution, unlocking archived tissues for whole transcriptome analysis and deeper insights into gene...

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nanowerk.com /2 weeks ago

DNA barcodes help nanopores detect multiple heavy metals

DNA-barcoded probes let nanopores identify which metal-ion signals belong to which targets, enabling multiplexed sensing in water and soil extracts.

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rna-seqblog.com /1 month ago

Programmable RNA detection enables multiplex virus identification

RNA sequencing advances support CRISPR-based detection methods that use kinetic signatures to identify multiple viruses and variants from RNA in a single, rapid diagnostic assay...

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rna-seqblog.com /1 month ago

Circular RNA replicons discovered in hot springs expand microbial diversity

RNA sequencing reveals diverse circular RNA replicons in hot spring microbes, expanding understanding of Obelisk elements and their role in microbial ecosystems...

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scitechdaily.com /3 weeks ago

Scientists Map Thousands of Brain Connections With RNA Barcodes

A new “barcode” technique is unlocking the brain’s hidden wiring faster than ever. Scientists have created a new way to map how brain cells connect by assigning each neuron a uniqu...

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nanowerk.com /2 weeks ago

DNA barcoding platform finds gold nanoparticles for precision cancer therapy

A new high-throughput platform screens dozens of nanoparticle designs in living systems to identify those that reach tumor mitochondria, enabling more precise and effective cancer...

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rna-seqblog.com /3 weeks ago

Non-destructive transcriptomics via vesicular export

RNA sequencing with NTVE enables repeated monitoring of gene expression in living cells, supporting time-course analysis of differentiation, perturbation responses, and cellular dy...

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rna-seqblog.com /3 weeks ago

Benchmarking nanopore RNA sequencing for m6A detection

RNA sequencing with nanopore technology improves m6A modification mapping when paired with calibrated workflows, helping reveal cell-specific RNA regulation in fibroblasts and neur...

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rna-seqblog.com /1 month ago

RNA sequencing moves toward absolute measurement of gene expression

RNA sequencing calibration using standardized references enables absolute quantification of gene expression, improving cross-study comparisons and reducing bias across experiments...

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rna-seqblog.com /2 weeks ago

Gel-free library preparation for next-generation RNA sequencing and small RNA quantification

RNA sequencing sensitivity improves with gel-free library preparation, reducing primer dimer artifacts and enhancing small RNA quantification from lower sample inputs...

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journals.plos.org /1 month ago

STARCall integrates image stitching, alignment, and read calling to enable scalable analysis of <i>in situ</i&g...

by Nicholas J. Bradley, Sriram Pendyala, Katie Partington, Douglas M. Fowler Fluorescent in situ sequencing involves imaging-based sequencing by synthesis in intact cells or tissu...

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rna-seqblog.com /1 month ago

longcallR – SNP calling, haplotype phasing and allele-specific analysis with long RNA-seq reads

RNA sequencing with long-read technology links genetic variants to transcript structure, uncovering allele-specific splicing and previously unannotated RNA events across human samp...

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rna-seqblog.com /3 weeks ago

RNA sequencing identifies blood-based biomarkers for inflammatory breast cancer

RNA sequencing using TGIRT technology reveals blood-based RNA biomarkers that may improve diagnosis and monitoring of inflammatory breast cancer through liquid biopsy...

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rna-seqblog.com /1 month ago

RNA sequencing without references uncovers hidden transcriptome features

RNA sequencing using reference-free analysis uncovers novel transcripts and hidden gene features, expanding discovery beyond traditional genome-based approaches...

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rna-seqblog.com /3 days ago

TAP-seq – targeted single-cell RNA and perturbation sequencing

TAP-seq combines genome editing with targeted RNA sequencing to enable sensitive and cost-effective single-cell functional genomics screens...

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rna-seqblog.com /1 month ago

CHOP researchers develop versatile and low-cost technology for targeted long-read RNA sequencing

Long-read RNA sequencing improves rare disease diagnosis by resolving transcript isoforms and variant effects, enabling more accurate interpretation of pathogenic splicing...

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rna-seqblog.com /1 month ago

SPTEdU-seq – parallel optics-free newborn cell tracking and spatial total transcriptional dynamics

RNA sequencing combined with spatial profiling tracks gene expression and cell proliferation, revealing dynamic cellular interactions and uncovering new insights into development.....

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rna-seqblog.com /1 month ago

RNA sequencing method maps RNA binding proteins with higher precision

RNA sequencing enables precise mapping of RNA binding protein targets, improving detection of low-abundance interactions and advancing understanding of gene regulation...

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bioengineer.org /3 weeks ago

tRNA-Derived 3′U-tRFSerTGA Signals Poor Myeloma Prognosis

In a groundbreaking study published in the British Journal of Cancer, researchers have uncovered a novel molecular player in the complex landscape of multiple myeloma pathogenesis—...

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rna-seqblog.com /1 day ago

Universal RNA signatures reveal common mechanisms of aging and mortality

RNA sequencing across multiple mammalian species identified conserved gene expression signatures linked to aging, mortality, chronic disease, and lifespan-modulating...

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rna-seqblog.com /1 month ago

FIRST-seq – a nanopore-based cDNA sequencing platform for RNA modification and structure profiling

RNA sequencing using nanopore technology enables detection of RNA modifications and structure at single-nucleotide resolution through reverse transcription error signatures...

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rna-seqblog.com /2 weeks ago

A*STAR scientists develop new method to reveal how RNA structure influences health and disease

RNA sequencing with the new sm-PORE-cupine method reveals how individual RNA molecules fold and behave, offering insights into gene regulation, viral biology, and therapeutic disco...

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rna-seqblog.com /1 week ago

miND standardizes small RNA sequencing analysis for biomarker discovery

RNA sequencing with the miND pipeline supports standardized small RNA analysis for biomarker discovery across tissues, plasma, extracellular vesicles, and other sample types...

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journals.plos.org /2 days ago

BINSEQ: A family of high-performance binary formats for nucleotide sequences

by Noam Teyssier, Alexander Dobin Modern genomics produces billions of sequencing records per run, which are typically stored as gzip-compressed FASTQ files. While this format is...

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