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A new study introduces "apical hypercontextualisation," explaining how psychedelics target serotonin receptors on layer V pyramidal neurons to shift brain processing from raw senso...
Psychedelics are often associated with disconnecting from reality, but a recent neuroimaging study found that psilocybin can actually make our brain activity more connected to the...
Psychedelics can create a new “hidden order” in brain activity that could explain how these drugs alter our sense of self
August 13, 2026 | Source: Nautilus | by Kristen French Mescaline, derived from cacti like peyote in North America and San Pedro in South America, is the drug that gave psychedelic...
How psychedelics can help us feel at one with existence.ScienceAlert stories are written, fact-checked, and edited by humans, never generated by AI. Don't miss a story, subscribe h...
Psychedelics are inherently chaotic drugs, dissolving the boundary between self and surrounds by sowing discord in the brain.Continue ReadingCategory:
A single dose of psilocybin produced measurable changes in brain activity and possible changes in brain structure that lasted for up to a month. Participants who experienced the gr...
As psychedelic therapies expand, new clinics treat uncommon long-term harms
Results from a late-stage study focused on generalized anxiety disorder were a “clean win” to analysts, who believe Definium has a drug with multibillion-dollar sales potential.
Researchers are looking at new ways to use psychedelics to treat depression. Science journalist Marcelo Leite says there's also a lot to learn from indigenous people who have used...
Kimon de Greef's The Ego Trip chronicles the rise of a potent psychedelic drug, from the toads that secrete it to the man who claimed it has amazing powers. Olivia Goldhill discove...
A psychedelic experience can crack your world wide open. But the window closes fast, and what you do while it's open decides whether anything actually lasts.
There’s a lot of it about and most dangerous when practised by billionaires… Sam Woolfe writes…. Being passionate and enthusiastic about psychedelics – or even evangelical about th...
Ibogaine joins a growing list of psychedelic drugs that have been found to potentially have beneficial effects on brain health and mood.
"A plausible mechanism for altered bodily awareness and perception."ScienceAlert stories are written, fact-checked, and edited by humans, never generated by AI. Don't miss a story,...
As public perception and legislation moves, psychedelic drugs could become accepted treatment for people battling a range of mental health disorders.
Psychedelic drugs are moving rapidly from counterculture to clinical science, but one central question continues to frustrate researchers: how can the same compound produce therape...
The real reason these treatments work may have been hiding in plain sight.
Ketamine and psychedelics share a neuroimmune signaling pathway involving IL-15 and IL-7, offering blood-based biomarkers to predict antidepressant response.
The real reason these treatments work may have been hiding in plain sight.
How the conservative activist Bryan Hubbard, with help from Rick Perry and Joe Rogan, persuaded Trump and the G.O.P. to embrace ibogaine, a psychedelic drug derived from an African...
Dimethyltryptamine (DMT) is getting lots of media attention. Is it the key to unlocking the secrets of reality, or just a popular means for escaping this one?
In a result that is already sending ripples through the fields of neuroscience and drug design, chemists at the University of California, Davis have performed something akin to a m...
The Sonoran Desert toad is the only animal known to make a psychedelic. Its glands secrete 5-MeO-DMT, the compound users call the God molecule. The toad exists only in Sonora, Mexi...
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