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yourstory.com /1 month ago

CrisprBits is using CRISPR to build faster tests for drug-resistant infections

The Bengaluru-based company has built three CRISPR platforms covering molecular diagnostics, gene editing and disease modelling, and is commercialising the diagnostics one first.

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genengnews.com /1 month ago

AI-Designed Synthetic CRISPR-Like Nucleases Show Activity in Cells

Scientists used artificial intelligence to design CRISPR nucleases with properties not found in nature, achieving activity that matches or exceeds natural enzymes despite the prote...

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genengnews.com /1 month ago

Genome-Scale CRISPRi Atlas Maps Gene Function Across Human iPSCs

A genome-scale CRISPRi atlas maps transcriptional consequences for 11,692 gene perturbations across more than 2.5 million human iPSCs. The resource reveals regulators of metabolism...

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genengnews.com /1 month ago

UCSD, IGI Partnership Expands CRISPR Innovation Across Health, Agriculture, and the Environment

UC San Diego has joined the Innovative Genomics Institute as its fourth UC partner, expanding collaboration to develop next-generation genome-editing technologies that address majo...

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rna-seqblog.com /3 weeks ago

Novel electromagnetically tunable gene switch enables precise control of gene expression

Single-cell RNA sequencing identified an electromagnetic field-responsive gene, enabling researchers to develop a reversible switch for precise, non-invasive control of gene expres...

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singularityhub.com /1 month ago

Scientists Are Designing CRISPR Gene Editors With AI

To make CRISPR better at its job, researchers are turning to algorithms like DeepMind's AlphaFold. The post Scientists Are Designing CRISPR Gene Editors With AI appeared first on S...

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rna-seqblog.com /6 days ago

New Johns Hopkins Study Identifies Pervasive RT-qPCR Artifact in CRISPR Knockdown Studies and How UltraMarathonRT® Solve...

Researchers at Johns Hopkins University identified a reverse transcription artifact that can distort RNA sequencing and RT-qPCR...

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habr.com /2 weeks ago

Как нейросеть придумала белки, которых нет в природе, и обошла эволюцию

В 2012 году ученые показали, что бактериальную систему CRISPR-Cas9 можно превратить в программируемые «ножницы» для ДНК. Через восемь лет Дженнифер Дудна и Эммануэль Шарпантье полу...

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newscientist.com /4 weeks ago

CRISPR-armed phages help treat severe superbug infection

Bacteria-killing phage viruses souped up with DNA-destroying CRISPR appear to have helped clear up a very serious infection caused by antibiotic-resistant E. coli

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fiercebiotech.com /1 month ago

Nobel Laureate Jennifer Doudna enters AI protein design arena

Jennifer Doudna, Ph.D., the Nobel Laureate best known for co-inventing the CRISPR system that has become the foundation for gene-editing, is dipping her toes into a new, buzzy fiel...

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scitechdaily.com /1 month ago

New CRISPR Tool Gives Scientists Control Over Cellular Protein Production

Controlling ribosomal RNA could help researchers target diseases driven by too little or too much protein production. Cells do not simply make proteins at a fixed pace. They contin...

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rna-seqblog.com /2 weeks ago

An end-to-end computational framework for “Record-seq” transcriptional recording data

A new framework adapts RNA sequencing analysis for Record-seq, improving spacer extraction, transcription-unit quantification, normalization, differential expression, and modeling...

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genengnews.com /4 weeks ago

BaseMap ABE Launched for Off-Target Characterization in Base Editing Therapeutic Development

Unlike prediction-based approaches, Broken String Biosciences says BaseMap ABE generates genome-wide data directly from biologically relevant cells, providing researchers with clea...

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scitechdaily.com /1 month ago

New Tool Supercharges Immunotherapy Against Prostate Cancer

Prostate tumors can vanish from the immune system’s radar. Now, scientists have found a way to strip away that disguise by changing the length of a single RNA molecule. Researchers...

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pandaily.com /1 month ago

Chinese Scientists Develop ContactSeek AI Framework Based on AlphaFold3 Contact Probability: A New Precision Paradigm fo...

Peking University team led by Yi Chengqi and East China Normal University develop ContactSeek using AlphaFold3 contact probability to identify key amino acids for precision base ed...

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bioengineer.org /4 weeks ago

OneCell CUT&Tag Maps Chromatin, Transcripts and Surface Markers, Revealing Epigenomic Reprogramming

A new single-cell technology is giving researchers an unusually complete view of how individual cells establish and change their identities. Called OneCell CUT&Tag, the method...

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marktechpost.com /1 month ago

How to Build Plasmid Engineering Workbench with Circular Mapping, Restriction Analysis, Virtual Gels, and Primer Design

In this tutorial, we build a Google Colab-native plasmid workbench that recreates the core ideas of SpliceCraft inside an interactive notebook environment. Instead of relying on a...

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bioengineer.org /1 month ago

HKU Researchers Develop ClairS for Accurate Mutation Detection Across Cancers

A new artificial-intelligence system developed by researchers at The University of Hong Kong could make it significantly easier to identify cancer-causing mutations hidden in the m...

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arstechnica.com /1 month ago

Team uses AlphaFold AI to redesign gene-editing proteins to make them safer

Google's AlphaFold can help ID what parts of a gene editing protein enable mistakes.

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genengnews.com /1 month ago

Fur Real: Biotech Startup Eliminates Major Dog Allergen in Beagle Pups Using CRISPR

The puppies represent a key first step towards addressing canine allergenicity and mark potentially a significant advance in veterinary biotechnology. The post Fur Real: Biotech St...

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bioengineer.org /1 week ago

Donor-matched prime editing enables precise, library-ready kilobase DNA insertions

Editing Without Cutting: New Prime-Editing Strategy Writes Kilobase-Scale DNA Into the Genome For years, the promise of precisely writing new DNA into the genome has been constrain...

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thehindubusinessline.com /1 month ago

Indian farmers may grow world’s first gene edited rice variety this winter

ICAR is expected to sign a MoU this month with US-based Corteva, which holds the license for the CRISPR-Cas9 gene-editing technology

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journals.plos.org /2 weeks ago

CLDN18.2 antibody design with protein language models: A deep learning optimization framework

by Tao Qu, Lingyan Yuan, Weiran Cui, Jiatian Tang, Zhitong Bing, Xianghong Xu, Jizheng Duan, Qiong Yang, Hui Cai CLDN18.2 is a promising tumor-specific antigen; however, the devel...

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goodmenproject.com /1 month ago

CRISPR Acts as Commander-In-Chief for Backup Defenses in Bacteria

The finding could help engineer more phage resistant bacteria--or to build better antibiotics The post CRISPR Acts as Commander-In-Chief for Backup Defenses in Bacteria appeared fi...

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