HSCT protecting against nerve loss
HSCT is no doubt the most potent immunomodulor and surprise surprise it is associated with reduced nerve loss so it suggests that stopping cells entering the CNS is a useful way to...
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HSCT is no doubt the most potent immunomodulor and surprise surprise it is associated with reduced nerve loss so it suggests that stopping cells entering the CNS is a useful way to...
by Shuji Wakatsuki, Toshiyuki Araki Neurodegeneration is frequently associated with oxidative stress, yet the mechanisms that convert reactive oxygen species (ROS) into irreversib...
Cyclic induction of the Yamanaka reprogramming factors for four weeks before stroke reduced ischemic brain damage, preserved neurons and myelin, and improved forelimb motor scores...
by Dong Won Kim Neurodegenerative diseases often damage some neuronal populations while sparing closely related neighbors. But instead of asking why some neurons die, should we be...
Researchers here identify the gene PLA2G2F as a regulator of compensatory responses to some of the damage and dysfunction of aging. The researchers were primarily investigating a p...
Glaucoma is a condition of progressive blindness driven by the death of retinal cells and degeneration of the optic nerve. It is driven by increased pressure in the aqueous humor,...
Mice kept more brain tissue and performed better on a memory test after researchers blocked an immune attack, without removing the tau tangles linked to Alzheimer’s. Scientists at...
Nerve damage is a consequence of poorly controlled MS and in one place it is easy to monitor nerve damage and this is in the eye. The eye is connected to your brain and nerve damag...
Scientists have found a promising way to protect the brain from Alzheimer’s-related damage by blocking immune cells that contribute to the destruction of neurons. In mice, the trea...
The immune system of the brain and body are distinct from one another, separated by the blood-brain barrier that lines blood vessels passing through the central nervous system. In...
Reducing inflammation partially restored the aging retina’s ability to generate new neurons from support cells, offering a possible route to improve experimental regeneration. To r...
Researchers developed a potential antibody-based approach to reducing neurodegeneration in tauopathies, with studies showing that in a mouse Alzheimer’s model anti-CXCR3-treated an...
Many of the more sophisticated forms of medicine, including gene therapies and immunotherapies, are challenging to deliver to the brain. At the very least there are far fewer pract...
An extract from the fruit of the Aegle marmelos plant reduced inflammation and damage to the myelin sheath in a rat model of multiple sclerosis (MS), a study reports. Researchers f...
New research shows that the age-related decline of the mitochondrial protein CHCHD2 disrupts the mitochondria-lysosome axis and drives proteostatic collapse in Lewy body disorders,...
Blocking a receptor called P2X7 significantly reduced inflammation in human brain tissue, revealing a potential new treatment strategy for neurological and psychiatric disorders. T...
An experimental drug reversed paralysis and vision loss in mice with a multiple sclerosis-like disease while also preserving nerve tissue. For the nearly one million Americans livi...
A study in human monocyte-derived microglia and human brain tissue slices suggests that inflammatory brain conditions, including traumatic brain injury and neurodegenerative diseas...
TBI is common, and healing requires reducing inflammation, restoring mitochondria, and boosting neuroplasticity. Low‑dose lithium may help.
Scientists have identified a protein that acts like a brake on the nervous system’s ability to repair damaged connections. Blocking AHR helped injured nerve fibers regrow and impro...
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Duke researchers developed an injectable scaffold that helped stroke-damaged brains grow new blood vessels, support nerve regrowth, and recover movement in mice. The treatment appe...
Stem cell transplants helped regenerate stroke-damaged brain tissue in mice, producing new neurons and restoring lost motor function. The treatment also improved blood vessels, inf...
Researchers here assess the present animal study evidence for first generation stem cell therapies to produce benefits in the most common neurodegenerative conditions, and also the...
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