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The pro-Alzheimer’s allele APOE4 makes hippocampal neurons in mice smaller and hyperexcitable. This effect, which resembles epilepsy and accelerated aging, can be mitigated by mani...
by Motomi Matsuno, Nozomi Uemura, Tomoyuki Miyashita, Kyogo S. Kobayashi, Agustin Liotta, Mayumi Kimura, Kyoko Ofusa, David Owald, Naoki Matsuo, Minoru Saitoe, Junjiro Horiuchi Ov...
by Raul de Palma Aristides, Pau Clusella, Roser Sanchez-Todo, Giulio Ruffini, Jordi Garcia-Ojalvo Neural mass models (NMMs) aim to capture the principles underlying mesoscopic neu...
by Carlos Coronel-Oliveros, Fernando Lehue, Rubén Herzog, Iván Mindlin, Marilyn Gatica, Natalia Kowalczyk-Grębska, Vicente Medel, Josephine Cruzat, Raul Gonzalez-Gomez, Hernán Hern...
by Arthur Fyon, Guillaume Drion Neurons rely on two interdependent mechanisms — homeostasis and neuromodulation — to maintain robust and adaptable functionality. Calcium homeostas...
by Sibi Pandian, Scott Rich Acetylcholine (ACh) affects both the intrinsic properties of individual neurons and the oscillatory tendencies of cortical microcircuits by modulating...
by Yue Yuan, Junyang Zhang, Chen Wang, Hao Yan, Ning Zhang, Kun Zhang, Zheshan Guo, Zhaoxiang Wang High-frequency stimulation (HFS), the basis of deep brain stimulation, elicits d...
How do abstract genetic mutations physically alter human brain wiring? A functional genomics study bridges the gap between schizophrenia genetics and cellular neurobiology.
In a groundbreaking study poised to reshape our understanding of neurodegenerative disorders, researchers have identified a compelling link between glymphatic system activity and t...
Researchers are developing a multiscale "neurometabolic" model to track how the brain's energy consumption drives aging and Alzheimer's. The $3.3M project aims to identify metaboli...
Neurons and glial cells utilize a specialized metabolic mechanism centered on leucine-derived acetyl-coenzyme A (AcCoA) to regulate the master growth hub, mTORC1.
Every second of the day, in roughly half of the 50 million people living with epilepsy, the brain stages tiny rebellions. Not seizures, exactly, but something almost as disruptive:...
In a groundbreaking study set to advance our understanding of metabolic regulation, researchers have uncovered the pivotal role played by thyrotropin-releasing hormone (TRH) neuron...
In a groundbreaking new study published in Nature Neuroscience, researchers have unveiled the intricate laminar architecture of cellular microcircuits that regulate human intericta...
A new study upends decades of neuroscientific dogma by proving that sodium concentrations vary drastically within individual astrocytes and across their sub-cellular processes.
by Dionysios Perdikis, Rita Sleimen-Malkoun, Viktor Müller, Viktor Jirsa Adaptive behavior depends on the brain’s capacity to vary its activity across multiple spatial and tempora...
A serendipitous discovery reveals that potassium ions act as ligands for brain receptors, offering new insights into epilepsy and brain homeostasis.
by Matthew Herbert Ning, Haoqi Sun, Brice Passera, Duygu Bagci Das, Brandon Westover, Alvaro Pascual-Leone, Emiliano Santarnecchi, Mouhsin M. Shafi, Recep A. Ozdemir Background Sub...
The electrodes were already there. Surgeons had threaded them months earlier, fine wires snaking through millimetre holes in the skull to sit inside the brain itself, recording the...
Chaos-based heartbeat analysis can non-invasively detect mental load where conventional methods fail.
Is anxiety an immune response? New research reveals that Hoxb8 microglia, specialized immune cells in the brain, use calcium signaling to switch anxiety and grooming behaviors on a...
Deep in the hippocampus, a molecular miscommunication is strangling memory. Long before a person with Alzheimer’s disease forgets a name or loses track of a familiar face, their ne...
by Thomas Zdyrski, Scott Pauls, Feng Fu Neural synchronization is central to cognition. However, incomplete synchronization often produces chimera states, where coherent and incoh...
by Karoline Horgmo Jæger, Aslak Tveito The synaptic cleft between neighboring neurons is the site of neurotransmitter-mediated communication that underlies normal brain function,...
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