Latest updates for Neuroinflammation

Fresh curated links around Neuroinflammation are collected here so marketers can spot useful updates and turn timely ideas into posts faster.

Recent items include:

  • Dendritic Cell Antigen Presentation Enables T Cells to Enter the Brain and Contribute to Tau Pathology
  • Anti-CXCR3 Therapy Reduces Harmful Immune Cell Infiltration into the Brain
  • Anti-Inflammatory Drug Target for Alzheimer’s, TBI, and Neurodegenerative Disease Identified

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fightaging.org /1 month ago

Dendritic Cell Antigen Presentation Enables T Cells to Enter the Brain and Contribute to Tau Pathology

The immune systems of the body and brain are distinct and separate, or at least largely separate, influencing one another via signaling. The blood-brain barrier keeps the vast majo...

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fightaging.org /2 weeks ago

Anti-CXCR3 Therapy Reduces Harmful Immune Cell Infiltration into the Brain

The immune system of the brain and body are distinct from one another, separated by the blood-brain barrier that lines blood vessels passing through the central nervous system. In...

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genengnews.com /2 weeks ago

Anti-Inflammatory Drug Target for Alzheimer’s, TBI, and Neurodegenerative Disease Identified

A study in human monocyte-derived microglia and human brain tissue slices suggests that inflammatory brain conditions, including traumatic brain injury and neurodegenerative diseas...

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sciencedaily.com /2 weeks ago

Drug target could block brain inflammation linked to Alzheimer’s and Parkinson’s

Blocking a receptor called P2X7 significantly reduced inflammation in human brain tissue, revealing a potential new treatment strategy for neurological and psychiatric disorders. T...

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fightaging.org /1 month ago

Senescent Microglia Secrete DLK1, Which Causes Dysfunction in the Aging Brain

Senescent cells accumulate with age in tissues throughout the body, disrupting tissue structure and function with inflammatory secretions. The growing burden of senescent cells is...

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fightaging.org /2 weeks ago

Chronic Inflammation in the Aging of Bone and Brain Tissue

Researchers here discuss the chronic inflammation of aging as a contribution to the bidirectional relationship between the loss of bone mineral density leading to osteoporosis and...

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journals.plos.org /1 week ago

Sparse neuronal C4 elevation induces network-wide transcriptomic and lipid-droplet remodeling in the cortical microenvir...

by Marta Sánchez-Carbonell, Sonia Bolshakova, Juan E. Ávila-Pagán, Yaseer A. Sabir, Clay Griffin-Derr, Dominik G. Stich, Sofia V. Cieslewicz, Sheyla Esther Carmen Sifuentes, Rhushi...

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journals.plos.org /1 week ago

Cellular diversity in neural organoids is critical for neurodegenerative disease modeling

by Shiying Liu, Shi-Yan Ng Neuroinflammation and vascular dysfunction are hallmarks of most neurodegenerative diseases. For organoids intended to model neurodegeneration, immune,...

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genengnews.com /1 month ago

Immune Cells Driving Alzheimer’s-Like Neurodegeneration Traced to Lymph Nodes

A study in mice traces immune cells that drive neurodegeneration to the body’s lymph nodes, suggesting that processes outside the brain contribute to the damage seen in various tau...

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scitechdaily.com /1 month ago

Alzheimer’s Brain Damage May Begin Outside the Brain

A study found that immune cells that drive neurodegeneration, the progressive damage and loss of nerve cells, originate in the body’s lymph nodes. In mice whose brains accumulate c...

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thehindu.com /1 month ago

Peripheral inflammation may drive brain damage in rare neurological disorder, finds NIMHANS study

Researchers identify link that could aid earlier diagnosis of Progressive Supranuclear Palsy 

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fightaging.org /1 month ago

Senolytic Treatments Clear Harmful Senescent Microglia from the Aging Brain

Researchers here show that a few different senolytic approaches improve the state of the population of microglia in the white matter of the brain in aged mice. This is much as one...

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fightaging.org /1 month ago

NRF2 Downregulation in Oligodendrocytes as a Contributing Cause of Cognitive Decline in Mice

Oligodendrocytes resident in the brain are responsible for maintaining the insulating myelin sheaths around axons that are required for the effective transmission of electrical imp...

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genengnews.com /3 weeks ago

Antibody Blocks T Cell Infiltration and Limits Neurodegeneration in Alzheimer’s Mice

Researchers developed a potential antibody-based approach to reducing neurodegeneration in tauopathies, with studies showing that in a mouse Alzheimer’s model anti-CXCR3-treated an...

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fightaging.org /1 month ago

Reprogramming Glia into Neurons Becomes Less Effective with Advancing Age

The research community is in the early stages of development of therapies for age-related neurodegeneration based on reprogramming the supporting glial cells of the brain to provok...

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fightaging.org /1 month ago

There is Such a Thing as Too Much of a Focus on the Brain in Neurodegenerative Disease

Every tissue in the body exchanges signals with every other tissue. Every tissue is dependent on specialized functions that are conducted elsewhere in the body. Thus in the matter...

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sciencedaily.com /3 weeks ago

Scientists found a surprising driver of Alzheimer’s outside the brain

Scientists found that immune cells contributing to Alzheimer’s-related brain damage may be activated in lymph nodes outside the brain before traveling into the nervous system. Bloc...

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parkinsonsnewstoday.com /1 month ago

Parkinson’s trial targets inflammation before motor symptoms emerge

A new clinical trial led by scientists at the Yale School of Medicine is testing whether targeting inflammation in people at high risk of Parkinson’s disease can prevent or slow di...

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multiplesclerosisnewstoday.com /1 day ago

Experimental therapy may curb chronic brain inflammation in MS

Genentech’s experimental oral therapy fenebrutinib may help control the chronic inflammation in the brain associated with disability progression in both relapsing forms of multiple...

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bioengineer.org /2 weeks ago

Hidden Brain Cells Called Oligodendrocytes Emerge as Unexpected Drivers of Parkinson’s Disease

A spatial multi-omics study in Nature Communications identifies disease-associated oligodendrocytes whose interleukin 33–ST2 signaling influences alpha-synuclein burden and motor s...

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bioengineer.org /1 month ago

Immune receptor MARCO drives shingles virus brain inflammation

Varicella zoster virus, the neurotropic herpesvirus behind chickenpox and shingles, has long been known to hide silently in sensory neurons after an initial infection, only to reaw...

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journals.plos.org /5 days ago

Oxidative signaling thresholds shape vulnerability in the central and peripheral nervous systems

by Shuji Wakatsuki, Toshiyuki Araki Neurodegeneration is frequently associated with oxidative stress, yet the mechanisms that convert reactive oxygen species (ROS) into irreversib...

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philstockworld.com /1 month ago

New clues suggest how destructive immune cells wreak havoc in the brain

A few years ago, scientists saw something surprising in the brain tissue of people who died with Alzheimer’s disease: white blood cells that multiply … Source

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scitechdaily.com /1 month ago

Scientists Discover Immune Cells Are Eating Living Neurons in ALS

Salk Institute scientists found that immune cells in the central nervous system identify and kill specific nerve cells in the spinal cords of mice with late-stage ALS, worsening th...

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Sources covering Neuroinflammation

feeds.feedburner.com

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bioengineer.org

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feeds.feedburner.com

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feeds.feedburner.com

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journals.plos.org

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journals.plos.org

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