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Microglia are innate immune cells resident in the brain, analogous to macrophages elsewhere in the body. Like macrophages, microglia are deeply involved in tissue maintenance as we...
Microglia are innate immune cells of the brain, very similar to the macrophages found elsewhere in the body outside the central nervous system. Both microglia and macrophages do mu...
Peripheral blood-derived immune cells cross into the aging human brain and transform into functional microglia.
A new study suggests that in amyotrophic lateral sclerosis – and possibly other neurodegenerative diseases – the brain’s immune cells devour stressed but still living neurons due t...
The central nervous system is relatively isolated from the rest of the body; the blood-brain barrier ensures that only certain cells and molecules are permitted to pass between the...
Microglia are innate immune cells of the brain, analogous to macrophages elsewhere in the body. Both cell types are deeply involved in the intricate processes of tissue maintenance...
Somatic mutations reveal the ontogeny of human microglia. Belk JA, Zhang Y, Shi Q, Ma L, Kalluru R, Enciso AM, Reilly EE, Weiss J, Li R, Eastman AE, Womack-Gambrel N, Paul D, Chakr...
Researchers here show that a few different senolytic approaches improve the state of the population of microglia in the white matter of the brain in aged mice. This is much as one...
In recent years, an increasing level of attention has been given to microglia as an important contribution to neurodegeneration in the aging brain. Microglia are innate immune cell...
Researchers have mapped over 830,000 brain immune cells, revealing a protective subtype of microglia that increases with Alzheimer’s progression. This subtype aids in clearing harm...
Salk Institute scientists found that immune cells in the central nervous system identify and kill specific nerve cells in the spinal cords of mice with late-stage ALS, worsening th...
Amyotrophic lateral sclerosis (ALS) is characterized by the loss of motor neurons. Aggregation of TDP-43 is thought to be involved in producing cell death in the brain. Here resear...
A new study in mice has identified a potentially important chain of events linking lipid accumulation in immune cells of the retina to progressive vision loss. The research, publis...
Scientists have discovered that the aging human brain may be far less isolated from the rest of the body than once believed. Stanford researchers found that large numbers of immune...
A study in mice traces immune cells that drive neurodegeneration to the body’s lymph nodes, suggesting that processes outside the brain contribute to the damage seen in various tau...
Human-specific duplicates of the SRGAP2 gene slow microglial maturation to four to eight years.
Senescent cells accumulate with age in tissues throughout the body, disrupting tissue structure and function with inflammatory secretions. The growing burden of senescent cells is...
Researchers found that TIMP2 supports microglial function and reduces age-related cellular changes associated with inflammation in mice. As the brain grows older, its immune cells...
A new study study shows specialized astrocytes repair brain damage by sending cell nuclei through long cellular extensions to rebuild glial networks.
by Chi Zhang, Shaolong Li, Ruizhi Jiang, Heng Duan, Chuang Li, Enlin Qi, Mingxin Wu, Xueying Li, Shiqing Feng, Hengxing Zhou m1A (N1-methyladenosine) is an important epigenetic me...
Glial fibrillary Acid Protein is a protein found in astrocytes and it can be released and measured in the blood, just like neurofilament can be a marker of nerves. Having spent yea...
Neuroinflammation, the persistent activation of the brain’s immune system, is increasingly recognized as a common driver of neurological damage. It appears in conditions ranging fr...
by Isabel Hubbard, Josh Dubnau The most common genetic cause of both familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is an expanded G4C2 repeat in t...
Researchers discovered that the youth-associated protein TIMP2 restores healthy immune function in the aging brain by rejuvenating microglia.
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