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medicalxpress.com /1 month ago

An enhancer within tumors provides a potential target for 'undruggable' MYC in pediatric medulloblastoma

Efforts to develop effective therapies for MYC-amplified Group 3 medulloblastoma (G3-MB) are hindered by an incomplete understanding of how MYC expression is controlled in these tu...

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genengnews.com /1 week ago

Oncogenic Signaling Shaped by a Golgi Trafficking Protein Pair

A new study shows that the Golgi proteins GOLPH3 and MYO18A control delivery of RTKs to the cell surface, defining signaling strength and revealing a potential vulnerability in RTK...

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bioengineer.org /2 weeks ago

Deadly Urothelial Cancer Linked to MYC Overexpression

In a groundbreaking study set to reshape the understanding of urothelial carcinoma (UC), researchers have elucidated the formidable role of the MYC proto-oncogene in dictating the...

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bioengineer.org /2 weeks ago

Cancer-Linked Protein Plays Key Role in Tumor DNA Repair

A groundbreaking study from Oregon Health & Science University (OHSU) unveils a previously unrecognized role of the notorious cancer-driving protein MYC. Long established as a...

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rna-seqblog.com /1 month ago

Long Non-Coding RNA May be a Promising Therapeutic Target for Cancer

RNA sequencing reveals how lncRNA IGF1R-AS1 drives MYC activation through chromatin looping, promoting tumor progression and highlighting a potential therapeutic target in prostate...

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sciencedaily.com /1 week ago

Scientists discover why some cancers survive chemotherapy

Scientists have uncovered a surprising new trick used by one of cancer’s most notorious proteins. MYC, already infamous for fueling runaway tumor growth, also appears to help cance...

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journals.plos.org /1 month ago

Constitutively active RAS prolongs Cdc42 signalling, while MAPK signalling is attenuated during fission yeast mating

by Emma J. Kelsall, Akatsuki Kimura, Ábel Vértesy, Kornelis R. Straatman, Mishal Tariq, Raquel Gadea, Chandni Parmar, Gabriele Schreiber, Shubhchintan Randhawa, Takashi Y. Ida, Cyr...

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bioengineer.org /3 weeks ago

tRNA-Derived 3′U-tRFSerTGA Signals Poor Myeloma Prognosis

In a groundbreaking study published in the British Journal of Cancer, researchers have uncovered a novel molecular player in the complex landscape of multiple myeloma pathogenesis—...

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prweb.com /3 weeks ago

AAAbio Introduces High-Specificity Anti-MYCT1 Antibody to Advance Cancer and Gene Regulation Research

AAAbio has launched a highly specific anti-MYCT1 antibody to support cancer and gene regulation research. Designed for techniques such as Western blot, ELISA, and flow cytometry, i...

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bioengineer.org /1 month ago

Notch Signaling Drives Colorectal Cancer Metastasis via SMADs

In an extraordinary breakthrough, researchers have unveiled critical insights into the enigmatic relationship between Notch and TGF-β signaling pathways in the context of colorecta...

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