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fightaging.org /1 month ago

The Evolved Balance of Unfolded Protein Response Activity in a Cell is Suboptimal for Longevity

That evolution does not optimize for species longevity is illustrated by the large number of small alterations in gene sequence or protein level that extend life in short-lived lab...

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journals.plos.org /4 weeks ago

Lysine deficiency within a conserved lysine desert is critical for EEL-1/HUWE1 to support ubiquitin proteasome system fu...

by Katherine S. Yanagi, Brenda J. Chen, Sheikh Omar Kunjo, Irini Topalidou, Nicolas Lehrbach Author summary: Cells must constantly destroy proteins that are damaged, abnormal, or n...

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fightaging.org /1 month ago

CLC-1 Inhibition Improves the Function of Neuromuscular Junctions in Aging Muscle

Sarcopenia is the name given to later, more severe stages of the characteristic loss of muscle mass and strength that takes place with age. The loss is universal, ultimately leadin...

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bioengineer.org /3 weeks ago

STARFISH Reveals Dendritic Translation and Neuroproteasome Degradation of Endogenous Tau

Alzheimer’s disease has long been associated with the accumulation of tau, a neuronal protein that normally helps organize and stabilize microtubules inside axons. In the disease,...

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journals.plos.org /1 day ago

ER-to-Golgi transport machinery promotes the excessive cargo-triggered unfolded protein response in <i>C</i>...

by Liying Guan, Tong Zhang, Zhigao Zhan, Yingchun Wang, Xun Huang, Mei Ding Disruption of endoplasmic reticulum (ER) homeostasis activates the unfolded protein response (UPR) to r...

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scitechdaily.com /1 month ago

A Hidden Protein-Folding Failure May Help Drive Diabetes

A study offers new insight into how insulin-producing cells could become more resilient to stress as diabetes progresses. Before proteins can work inside a cell, they must twist an...

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bioengineer.org /1 month ago

Early Parkinson’s disease: α-Synuclein disrupts co-translational protein transport into the endoplasmic reticulum

Parkinson’s disease may begin damaging cells long before tremors, stiffness, and slowed movement become visible. A new study published in Nature Communications identifies an early...

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journals.plos.org /1 day ago

Correction: Quantitative and Kinetic Proteomics Reveal ApoE Isoform-dependent Proteostasis Adaptations in Mouse Brain

by Nathan R. Zuniga, Noah E. Earls, Ariel E. A. Denos, Jared M. Elison, Benjamin S. Jones, Ethan G. Smith, Noah G. Moran, Katie L. Broce, Gerome M. Romero, Chad D. Hyer, Kimberly B...

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bioengineer.org /2 weeks ago

Proteomics Links Environmental and Genetic Parkinson’s Models to Purine Metabolism

Parkinson’s disease has long been described as a disorder of dopamine-producing neurons, but a new comparative study suggests that its molecular story may be far broader—and more c...

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fightaging.org /1 month ago

Mitochondrial Dysfunction in Parkinson's Disease is Complicated

Like many age-related conditions, Parkinson's disease is associated with uncommon mutations and genetic variants that increase its likelihood, severity, and pace of progression. PI...

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fightaging.org /1 day ago

Age Acceleration in Various Proteomic Clocks Correlates with Risk of Mortality and Age-Related Disease

In recent years, researchers have been gathering as much data as possible on the behavior of aging clocks of various sorts. The study here is an example of the type, in which multi...

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sciencedaily.com /1 month ago

Scientists may have found aging’s hidden trigger for brain disease

Scientists have identified a molecular switch that may help explain why aging makes the brain more vulnerable to diseases such as ALS and Huntington’s. In worms, the protein EPS8 b...

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fightaging.org /1 day ago

The Adaptive Cost Hypothesis of Aging, a Viewpoint on Antagonist Pleiotropy

At the high level, without delving into specific mechanisms, the consensus view on aging is that it exists in the shadow of natural selection. The selection pressure that drives th...

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fightaging.org /1 week ago

Mistranslation Mutations in Flies Surprisingly Extend Life

One might think that an alteration to the machinery of gene expression that systemically changes the amino acid components of proteins, in effect giving all proteins the possibilit...

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fightaging.org /1 month ago

A Novel View of Age-Related Mitochondrial Dysfunction as a Failure of Adaptability

Every cell contains hundreds of mitochondria, the evolved descendants of what were once symbiotic bacteria. Much of the original mitochondrial DNA has migrated into the cell nucleu...

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lifespan.io /1 month ago

Engineered Enzyme Reverses Age-Related Protein Damage

Scientists have engineered an enzyme that removes an advanced glycation end product (AGE) from proteins. This type of age-related modification, which affects protein function and c...

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fightaging.org /1 week ago

Senescent Cells in Metabolic Disorders

The most common metabolic diseases, such as type 2 diabetes or fatty liver disease leading to metabolic dysfunction-associated steatohepatitis (MASH), a fibrotic condition of the l...

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fightaging.org /1 month ago

More on the Mechanisms by Which Reducing Age-Related Peroxisome Loss Extends Life

You might recall that last year researchers demonstrated an age-related decline in peroxisome number in cells. Peroxisomes carry out a range of functions related to oxidative and l...

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fightaging.org /1 week ago

NRF2 Downregulation in Oligodendrocytes as a Contributing Cause of Cognitive Decline in Mice

Oligodendrocytes resident in the brain are responsible for maintaining the insulating myelin sheaths around axons that are required for the effective transmission of electrical imp...

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fightaging.org /1 month ago

A View of Aging Centered Around the Role of Karyopherins and Nuclear Transport

The biochemistry of aging is enormously complex, and it is very hard to pick apart which changes are definitively cause versus effect, and which changes are definitively more impor...

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sciencedaily.com /1 month ago

Misfolded insulin may be quietly driving diabetes

Researchers found that insulin-producing cells depend on a team of helper proteins to keep insulin production on track. When one key partner was missing, damaged proteins built up...

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fightaging.org /2 weeks ago

Proposing Restoration of Circadian Rhythm as an Approach to Treat Sarcopenia

Circadian rhythm becomes disrupted with age, and a growing body of evidence points to this form of dysfunction as a contribution to many aspects of aging. The fine details of how a...

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journals.plos.org /1 month ago

Prolines in linkers of multi-domain proteins: Intrinsic regulators of misfolding and aggregation

by Simona Manasra, Yaakov Levy Proline is a chemically unique amino acid that influences protein structure and slows peptide-bond formation during translation. While its enrichmen...

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lifespan.io /1 month ago

More Autophagy Reduces Toxin-Induced Kidney Failure in Mice

Autophagy, which increases in younger mice under toxic stress, does not increase in older mice and leaves them susceptible to acute kidney injury (AKI). Increasing autophagic flux...

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