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rna-seqblog.com /1 day ago

NanoncRNA-seq – an rRNA-depleted full-length transcriptome strategy for identification of novel lncRNA isoforms

A new RNA sequencing workflow using nanopore technology improves full-length lncRNA isoform discovery, revealing many previously undetected transcripts missed by conventional short...

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rna-seqblog.com /1 month ago

Long-read RNA sequencing reveals how alternative splicing shapes immune responses

Long-read RNA sequencing revealed extensive alternative splicing changes in activated human monocytes, uncovering functional isoforms that enhance immune protein production during...

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rna-seqblog.com /1 week ago

Nanopore direct RNA sequencing expands the view of the transcriptome

RNA sequencing using nanopore direct RNA sequencing enables simultaneous analysis of native RNA molecules, transcript isoforms, RNA modifications, and poly(A) tails for comprehensi...

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rna-seqblog.com /2 days ago

Amaranth – enhanced single-cell transcript assembly via discriminative modelling of UMI reads and internal reads

Amaranth improves transcript reconstruction from RNA sequencing data by modeling different read types, enabling more accurate isoform analysis at single-cell resolution...

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rna-seqblog.com /1 day ago

Examining the impact of aging on critical cellular processes

Combining short- and long-read RNA sequencing reveals how aging alters gene expression, splicing, and transcription, providing new insights into the molecular processes that drive...

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rna-seqblog.com /1 month ago

New eBook | RNA-seq: A peek inside the transcriptome

This collection highlights how RNA sequencing is advancing transcriptomics research, from single-cell analysis and disease mechanisms to nanopore sequencing and AI-driven data inte...

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scitechdaily.com /3 weeks ago

This New DNA Test Solves Rare Disease Mysteries That Standard Genetics Misses

A new long-read DNA test improves rare disease diagnosis, replaces multiple existing tests, and could become the preferred global standard for genetic diagnostics. A new DNA test i...

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dev.to /3 days ago

Anatomy of a Full RAG Application: Every Concept, One Self-Hosted Stack

"Chat with your documents" sounds simple. Then you build it, and you discover a good RAG system is really eight systems wearing a trench coat. I recently finished myRAG вЂ” a full...

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roberthopman.com /1 month ago

linecounter: a fast quality read for a Ruby repo

Originally appeared on Blog.I wanted a fast way to read the quality of a Ruby repository, so I wrote a small gem called linecounter. Why bother Most files should not be too long,...

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ipscell.com /2 weeks ago

Weekly reads: more FDA flexibility on rare diseases, elephant iPS cells, heritable human CRISPR, RTT rarely used, digit...

The last eighteen months have been an unprecedented time of unpredictability for the FDA, but moving forward we’re likely going to see an emerging consistency: a higher amount of F...

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thejournal.ie /1 month ago

Sitdown Sunday: Inside the hantavirus-hit cruise ship

Settle down in a comfy chair with some of the week’s best longreads.

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thejournal.ie /1 month ago

Sitdown Sunday: Inside the hantavirus-hit cruise ship

Settle down in a comfy chair with some of the week’s best longreads.

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rna-seqblog.com /22 hours ago

STGBench – sequencing-level spatial DNA-RNA simulation for multimodal and virtual cell-oriented benchmarking of genomic...

STGBench generates realistic paired DNA and RNA sequencing datasets with known genetic alterations, enabling accurate benchmarking of spatial genomics and transcriptomics analysis....

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journals.plos.org /1 month ago

Challenges and progress in RNA velocity: Comparative analysis across multiple biological contexts

by Sarah Ancheta, Leah Dorman, Guillaume Le Treut, Abel Gurung, Greg Huber, Loïc A. Royer, Alejandro Granados, Merlin Lange Single-cell RNA sequencing is revolutionizing our under...

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bioengineer.org /1 month ago

New Test Offers Comprehensive DNA Analysis for Rare Genetic Disorders

A groundbreaking advancement in the diagnosis of rare genetic disorders has emerged from the collaborative efforts of researchers at Radboud University Medical Center and Maastrich...

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journals.plos.org /3 weeks ago

GrassSV – hybrid method to detect structural variants in high throughput DNA-seq data

by Dominik Witczak, Krzysztof Sychla, Julia Wysocka, Artur Laskowski, Wojciech Frohmberg, Marta Glowacka, Alicja Dzik, Piotr Lukasiak, Jacek Blazewicz, Aleksandra Swiercz Genetic...

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timriley.info /1 month ago

Continuations 2026/20: Repeated reads

Originally appeared on Tim Riley. A proud moment this week! After Sean made a nice performance related enhancement to Dry Configurable (now you can call #to_data on your config...

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