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Latest updates for Long Reads

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rna-seqblog.com /1 month ago

Short-read RNA-seq yields lower estimates of A-to-I RNA editing levels than long-read cDNA sequencing

RNA sequencing comparisons show that short reads can underestimate A-to-I RNA editing, while long-read sequencing provides more accurate measurements through improved genomic align...

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rna-seqblog.com /3 weeks ago

Long-read RNA sequencing reveals how neurons choose alternative RNA endings

Long-read RNA sequencing and APALORD reveal how alternative polyadenylation changes during neuronal differentiation and identify new patterns of RNA processing across species...

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rna-seqblog.com /2 weeks ago

How should biological replicates be handled in long-read RNA sequencing?

Long-read RNA sequencing analysis shows that handling biological replicates differently can influence transcript reconstruction and the discovery of novel RNA isoforms...

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bioengineer.org /4 weeks ago

Near-Perfect Long Reads Reveal Hidden Mosaicism Left Behind by CRISPR Gene Editing

CRISPR-Cas9 has transformed the life sciences by giving researchers a seemingly simple tool for cutting DNA at chosen locations, but a new study published in Genome Medicine delive...

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thejournal.ie /6 days ago

Sitdown Sunday: Why the Cornell story is resonating worldwide

Settle down in a comfy chair with some of the week’s best longreads.

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thejournal.ie /1 month ago

Sitdown Sunday: The crime writer who believes he has finally identified the Zodiac Killer

Settle down in a comfy chair with some of the week’s best longreads.

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rna-seqblog.com /1 month ago

A real-data approach to evaluating RNA transcript analysis methods

RNA sequencing data provide a real-world framework for comparing differential transcript usage methods across bulk, single-cell, spatial, long-read, and short-read transcriptomics....

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ipscell.com /1 month ago

Weekly reads: Longeveron MSC trial disappoints, CRISPR ancestor VIPR, distinct human brain progenitors, FDA staffing woe...

Longeveron is a biotech focused on mesenchymal stromal/stem cells or MSCs. Its big news this year was a report in Cell Stem Cell about a potential benefit for frailty from its prod...

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abnormalreturns.com /1 month ago

Longform links: actual writing

Thursdays are all about longform links on Abnormal Returns. Wherever possible, free links for premium sites are used. You can check out...

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rna-seqblog.com /1 month ago

An end-to-end computational framework for “Record-seq” transcriptional recording data

A new framework adapts RNA sequencing analysis for Record-seq, improving spacer extraction, transcription-unit quantification, normalization, differential expression, and modeling...

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abnormalreturns.com /1 month ago

Longform links: entertaining the reader

Thursdays are all about longform links on Abnormal Returns. Wherever possible, free links for premium sites are used. You can check out...

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rna-seqblog.com /1 month ago

Eclipsebio expands its RNA characterization capabilities with multi-attribute nanopore-based sequencing assay eSTRAND RN...

RNA sequencing with eSTRAND RNA QC enables simultaneous measurement of RNA identity, poly(A) tail length, capping efficiency, fragmentation hotspots, and dsRNA...

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ipscell.com /1 week ago

Weekly reads: stem cell and peptides via RFK Jr., Urnov vs. Tie exchange fire, med centers cash in on longevity, the en...

What’s the stem cell and peptides connection? The first time I heard of “peptides” (meaning the unproven wellness ones) it was from a fan of unproven stem cell clinics. It was an a...

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medium.com /3 weeks ago

RAG vs Long-Context LLMs: Why Bigger Context Windows Do Not Solve Retrieval

Large Language Models can now process hundreds of thousands, and sometimes even millions, of tokens.Continue reading on Medium »

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rna-seqblog.com /2 days ago

RNA sequencing reveals how genes combine to regulate inflammation and immune responses

Long-read RNA sequencing reveals functional chimeric mRNAs formed from distant genes, identifying a previously unknown protein that regulates inflammation, antibacterial immunity a...

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journals.plos.org /1 month ago

Characterization of METTL3/14-mediated m<sup>6</sup>A modification in human transcriptome using Nanopore dir...

by Emily Kurtyan, Andrew J. Stein, Kelly J. Abdalla, Zhangerjiao Yuan, Miten Jain, Fadia Ibrahim Post-transcriptional RNA modifications modulate diverse aspects of RNA metabolism....

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rna-seqblog.com /1 month ago

Ultrafast and reference-free sequence discovery in single-cell data

Malva enables ultrafast, reference-free searches across massive single-cell RNA sequencing datasets for mutations, splice junctions, pathogens, transcripts, and other sequence-leve...

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rna-seqblog.com /1 day ago

Recordanelles enable RNA sequencing to capture a history of gene activity in living cells

Researchers developed recordanelles that preserve gene expression histories for days, allowing single-cell RNA sequencing to detect transient cellular responses that conventional m...

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thejournal.ie /1 week ago

Sitdown Sunday: The alleged smear campaigns trying to destroy reputations in Hollywood

Settle down in a comfy chair with some of the week’s best longreads.

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bookriot.com /1 month ago

рџ“љ High-end reading

A couple big business deals in the world of books this week

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rna-seqblog.com /1 month ago

Eclipsebio expands its RNA characterization capabilities with multi-attribute nanopore-based sequencing assay eSTRAND RN...

Eclipsebio’s eSTRAND RNA QC uses direct RNA sequencing to measure multiple RNA quality attributes, including identity, poly(A) tails...

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ipscell.com /6 days ago

Weekly reads: G&D trio, Regenative Labs sues FDA, OCT4 sub, SpudCells, SRSF1 as an anti-aging factor?

Early on in my career as a graduate student in Mark Kamps’ lab, we had some go-to journals like G&D and MCB. Such journals often published papers in our areas of interest on Ho...

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genengnews.com /5 days ago

ASHG: Long-Read Genomics Meets Clinical Data in PacBio, Verily Health AI Deal

A multi-year collaboration will connect PacBio's HiFi sequencing with Verily Pre, combining long-read genomic and clinical data for biomedical research and AI model development. Th...

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ritholtz.com /1 month ago

10 Sunday Reads

The weekend is here! Pour yourself a mug of Danish Blend coffee, grab a seat outside, and get ready for our longer-form weekend reads: • How Three Brothers Built an AI Slop Empire...

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