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rna-seqblog.com /1 month ago

longcallR – SNP calling, haplotype phasing and allele-specific analysis with long RNA-seq reads

RNA sequencing with long-read technology links genetic variants to transcript structure, uncovering allele-specific splicing and previously unannotated RNA events across human samp...

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rna-seqblog.com /1 month ago

CHOP researchers develop versatile and low-cost technology for targeted long-read RNA sequencing

Long-read RNA sequencing improves rare disease diagnosis by resolving transcript isoforms and variant effects, enabling more accurate interpretation of pathogenic splicing...

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journals.plos.org /1 month ago

QoALa: A comprehensive workflow for viral quasispecies diversity comparison using long-read sequencing data

by Nakarin Pamornchainavakul, Declan C. Schroeder, Kimberly VanderWaal The concept of viral quasispecies refers to a constantly mutating viral population occurring within hosts, w...

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rna-seqblog.com /1 month ago

A long-read RNA sequencing and polysome profiling framework reveals transposable element-driven transcript diversity

RNA sequencing reveals how transposable elements drive alternative splicing and alter translation in glioblastoma, generating diverse RNA isoforms linked to cancer progression...

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rna-seqblog.com /2 weeks ago

FUSILLI -long-read fusion detection

RNA sequencing with FUSILLI improves detection of leukemia fusion oncogenes, supporting more accurate molecular diagnosis and subtyping in pediatric B-cell acute lymphoblastic leuk...

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rna-seqblog.com /3 weeks ago

SCOTCH – isoform-level characterization of gene expression through long-read single-cell RNA sequencing

RNA sequencing with SCOTCH improves isoform-level analysis from long-read single-cell data, helping reveal cell-type-specific transcript diversity and novel RNA isoforms

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rna-seqblog.com /1 month ago

Children’s Hospital of Philadelphia researchers develop new RNA sequencing platform for diagnosing rare diseases

RNA sequencing using targeted long-read approaches enables detection of disease-causing variants by revealing how genetic changes disrupt full-length RNA molecules...

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rna-seqblog.com /1 month ago

RNA sequencing without references uncovers hidden transcriptome features

RNA sequencing using reference-free analysis uncovers novel transcripts and hidden gene features, expanding discovery beyond traditional genome-based approaches...

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towardsdatascience.com /1 month ago

I Built an AI Pipeline for Kindle Highlights

A local, zero-cost project that cleans, structures, and summarizes your reading automatically The post I Built an AI Pipeline for Kindle Highlights appeared first on Towards Data S...

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bookriot.com /1 month ago

So You Want to Be Well-Read

Give me a good hour+ deep dive into books and I'm there.

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thejournal.ie /3 weeks ago

Sitdown Sunday: The world leaders who want to live forever

Settle down in a comfy chair with some of the week’s best longreads.

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roberthopman.com /6 days ago

linecounter: a fast quality read for a Ruby repo

Originally appeared on Blog.I wanted a fast way to read the quality of a Ruby repository, so I wrote a small gem called linecounter. Why bother Most files should not be too long,...

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rna-seqblog.com /1 month ago

Circular RNA replicons discovered in hot springs expand microbial diversity

RNA sequencing reveals diverse circular RNA replicons in hot spring microbes, expanding understanding of Obelisk elements and their role in microbial ecosystems...

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rna-seqblog.com /3 weeks ago

Benchmarking nanopore RNA sequencing for m6A detection

RNA sequencing with nanopore technology improves m6A modification mapping when paired with calibrated workflows, helping reveal cell-specific RNA regulation in fibroblasts and neur...

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rna-seqblog.com /1 month ago

FIRST-seq – a nanopore-based cDNA sequencing platform for RNA modification and structure profiling

RNA sequencing using nanopore technology enables detection of RNA modifications and structure at single-nucleotide resolution through reverse transcription error signatures...

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journals.plos.org /1 month ago

ntStat: k-mer characterization using occurrence statistics in raw sequencing data

by Parham Kazemi, Lauren Coombe, René L. Warren, Inanc Birol K-mer counts are fundamental in many genomic data analysis tasks, providing valuable information for genome assembly,...

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thejournal.ie /6 days ago

Sitdown Sunday: Inside the hantavirus-hit cruise ship

Settle down in a comfy chair with some of the week’s best longreads.

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thejournal.ie /6 days ago

Sitdown Sunday: Inside the hantavirus-hit cruise ship

Settle down in a comfy chair with some of the week’s best longreads.

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rna-seqblog.com /1 month ago

SPTEdU-seq – parallel optics-free newborn cell tracking and spatial total transcriptional dynamics

RNA sequencing combined with spatial profiling tracks gene expression and cell proliferation, revealing dynamic cellular interactions and uncovering new insights into development.....

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ipscell.com /2 weeks ago

Weekly reads: lab-grown sperm, stem cell pills, intranasal EVs, EMF Cell paper doubts, Makary toast?

Have we reached the reproductive frontier of lab-grown sperm? Producing oocytes in the lab has always been thought to be the initial focus in this arena. It was thought that figuri...

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rna-seqblog.com /1 month ago

Single-cell total RNA sequencing expands our view of gene regulation

RNA sequencing captures both coding and noncoding RNAs at single-cell resolution, revealing complex regulatory programs and cellular identities across development and disease...

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timriley.info /1 week ago

Continuations 2026/20: Repeated reads

Originally appeared on Tim Riley. A proud moment this week! After Sean made a nice performance related enhancement to Dry Configurable (now you can call #to_data on your config...

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journals.plos.org /1 month ago

STARCall integrates image stitching, alignment, and read calling to enable scalable analysis of <i>in situ</i&g...

by Nicholas J. Bradley, Sriram Pendyala, Katie Partington, Douglas M. Fowler Fluorescent in situ sequencing involves imaging-based sequencing by synthesis in intact cells or tissu...

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journals.plos.org /3 weeks ago

AIEdit: Alignment-free genome assembly polisher trained on spaced seed match patterns

by Parham Kazemi, Ivana Sánchez Olivares, René L. Warren, Lauren Coombe, Inanc Birol Polishing, the process of correcting base-level errors in genome assemblies, is a critical ste...

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