NextLongIso – a comprehensive Nextflow pipeline for multi-dimensional long-read RNA-seq analysis
NextLongIso provides a unified RNA sequencing pipeline for analyzing transcript isoforms, alternative splicing, promoter usage, and...
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NextLongIso provides a unified RNA sequencing pipeline for analyzing transcript isoforms, alternative splicing, promoter usage, and...
A new RNA sequencing workflow using nanopore technology improves full-length lncRNA isoform discovery, revealing many previously undetected transcripts missed by conventional short...
RNA sequencing benchmark compares long-read bioinformatics tools for single-cell and spatial transcriptomics, helping researchers improve isoform detection and gene...
Long-read RNA sequencing combined with practical quality-control measures reduces mapping bias and improves the accuracy of allele-specific gene expression measurements...
The LRUA26 meeting highlights advances in long-read RNA sequencing, including full-length isoform analysis, genome assembly, structural variation, epigenetics, and emerging researc...
RNA sequencing with ISAtools enables accurate reconstruction and quantification of full-length RNA isoforms while efficiently processing large PacBio sequencing datasets...
Amaranth improves transcript reconstruction from RNA sequencing data by modeling different read types, enabling more accurate isoform analysis at single-cell resolution...
Tidesurf improves RNA sequencing analysis by accurately quantifying spliced and unspliced transcripts across 3' and 5' protocols for more reliable RNA velocity estimates...
by Hai Li, Xudong Wu, Hailong Huo, Xia Zhang, Yiming Guo, Wan Lin, Feidi Wen, Zhijun Zhao, Guiying Zhao, Jinlong Huo Acting as the central endocrine hub, the pituitary gland is cl...
Settle down in a comfy chair with some of the week’s best longreads.
RNA sequencing and Iso-Seq improve potato and tomato transcript annotations, revealing additional isoforms and enabling more accurate analysis of gene expression and alternative sp...
Combining short- and long-read RNA sequencing reveals how aging alters gene expression, splicing, and transcription, providing new insights into the molecular processes that drive...
From plot twists to stunning visuals, our flagship long-form journalism can be as gripping as any beach read. To mark the publication of the summer issue of the Guardian Long Read...
RNA sequencing model NB-Lib predicts sequencing depth requirements from shallow pilot data while accounting for library complexity, amplification differences, and molecular recover...
A new framework adapts RNA sequencing analysis for Record-seq, improving spacer extraction, transcription-unit quantification, normalization, differential expression, and modeling...
Thursdays are all about longform links on Abnormal Returns. Wherever possible, free links for premium sites are used. You can check out...
"Chat with your documents" sounds simple. Then you build it, and you discover a good RAG system is really eight systems wearing a trench coat. I recently finished myRAG — a full...
by Emily Kurtyan, Andrew J. Stein, Kelly J. Abdalla, Zhangerjiao Yuan, Miten Jain, Fadia Ibrahim Post-transcriptional RNA modifications modulate diverse aspects of RNA metabolism....
A practical pipeline for document ingestion, embedding, and retrieval, all on the JVM, with a Spring AI comparison for good measure. For a long time, if you wanted to build a Retri...
Malva enables ultrafast, reference-free searches across massive single-cell RNA sequencing datasets for mutations, splice junctions, pathogens, transcripts, and other sequence-leve...
RNA sequencing combined with tissue expansion enabled ultra-high-resolution spatial transcriptomics, allowing researchers to map gene activity within individual cells with...
STGBench generates realistic paired DNA and RNA sequencing datasets with known genetic alterations, enabling accurate benchmarking of spatial genomics and transcriptomics analysis....
by Paul R. Munn, Jay Chia, Charles G. Danko Functional element annotations are critical tools used to provide insight into the molecular processes governing cell development, diff...
Roche's AXELIOS 1 enters next generation DNA sequencing. Can it or rivals unseat Illumina's long-standing market dominance? The post Roche’s new gene sequencer on the market: where...
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