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Questions regarding the relative importance of different mechanisms and dysfunctions to the progression of aging and eventual mortality are hard to answer definitively. Even given...
A new study in Nature Aging is drawing attention to a possible biological engine behind inflammaging—the chronic, low-grade inflammation that rises with age and is linked to cardio...
Senescent cells accumulate with age, and actively secrete pro-inflammatory signals. The present understanding of senescent cell biochemistry and animal studies of senescent cell cl...
A study found a new mitochondrial pathway in senescent cells that alters how DNA is stored, exposing genes linked to inflammation. Inflammation is essential when the body needs to...
In recent years, an increasing level of attention has been given to microglia as an important contribution to neurodegeneration in the aging brain. Microglia are innate immune cell...
The retina is a part of the central nervous system, and as such is subject to a variety of forms of age-related neurodegeneration, culminating in conditions such as macular degener...
A new study suggests that aging or Parkinson’s-triggering mutations create inflammation in peripheral tissues, and then circulating extracellular vesicles spread it to the brain, w...
STING is a master regulator of inflammatory signaling, triggered by a range of different sensor proteins for foreign material or forms of damage within a cell. With age, these sens...
Dysfunctional mitochondria may drive age-related inflammation by helping switch on inflammatory genes, and blocking SLC25A1 reduced that activity. As people age, senescent cells ac...
Blocking a single inflammatory receptor protected mice from many of aging’s most damaging effects. Aging may be driven in part by a breakdown in the body’s cleanup system. New rese...
Using cohort studies and a mouse model, researchers have found that the circulating factor ANGPTL8, which is produced by senescent fat cells, is related to age-related diseases and...
The thymus is primarily noted as being the site of T cell maturation, essential to the supply of new T cells to maintain the adaptive immune system. It declines in function relativ...
Aging may be partly fueled by immune cells losing their ability to clear away damaged, inflammation-promoting cells. Blocking a single receptor restored that cleanup process in mic...
Microglia are innate immune cells of the brain, very similar to the macrophages found elsewhere in the body outside the central nervous system. Both microglia and macrophages do mu...
A recent study identified the thymus hormone thymulin as a molecule with the potential to reduce inflammation in an age-dependent manner. Treating cancer-bearing mice with this mol...
Cells become senescent throughout life, because of stress or damage or reaching the Hayflick limit on replication, but senescent cells only begin to accumulate with age. When a cel...
Senescent cells accumulate with age in tissues throughout the body, disrupting tissue structure and function with inflammatory secretions. The growing burden of senescent cells is...
As populations age, scientists are looking more closely at a hidden biological process that may help explain why some older adults remain mobile and independent while others experi...
Think you have no choice but to accept a higher risk of conditions like Alzheimer’s disease, type 2 diabetes and heart disease as you get older? Think again! Experts say these and...
Crosstalk between mitochondrial metabolism and epigenetic regulation helps activate the inflammatory SASP in senescent cells, revealing a potential therapeutic target for limiting...
Microglia are innate immune cells resident in the brain, analogous to macrophages elsewhere in the body. Like macrophages, microglia are deeply involved in tissue maintenance as we...
One of the hallmarks of dysfunctional lipid metabolism in the brain the context of age-related neurodegenerative disease is an increase in lipid droplets in brain cells. This is se...
Aging does not follow a single biological script. Some people remain physically active and cognitively resilient well into later life, while others develop chronic inflammation, me...
Alzheimer's disease, and the other common age-related neurodegenerative conditions, are characterized by chronic inflammation in brain tissue. Aging in general is characterized by...
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