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Avenue Biosciences´ machine learning-powered platform engineers and screens signal peptide variants to increase protein secretion from cells. Circio’s circVec technology has demons...
Because we are dealing with foundational scientific discoveries, we will address several “So what?” questions. Source
A new study has found that the signals cells use to switch genes on have remained almost unchanged across two billion years of evolution, but the ones used to switch genes off vary...
If the theory can explain the evolution of new genes then evolution can be a successful explanation. Source
These are the same type of understandable and logical computation circuits that humans design. What can we learn from observing this similarity? Source
A study of worms finds a protein that helps shape the structure of the genome is critical for establishing the identity of some neurons.
The collaboration brings together Synastra’s expertise in genomic engineering, AAV vector design, rare-disease gene therapy, and translational development with NewBiologix’s propri...
Cells constantly control the fate of their proteins. They remove proteins that are worn out or no longer needed, but can also alter their activity, localization, or interactions wi...
Nearly every cell in the human body contains essentially the same genetic information, yet different cells activate different genes. For regulatory proteins to reach these genes, D...
The PROPEL program aims to control gene expression through RNA structure, building logic-gated RNA therapies that switch on only where and when intended, without altering the genom...
DNA regulatory elements, which control when, where, and to what extent specific genes are turned on or off, can be co-opted by scientists to create gene switches. The post Gene Sw...
Primate color vision depends on three cone pigments that all bind the same chromophore, 11-cis-retinal. Yet small differences in the surrounding protein tune each pigment to differ...
A more coherent approach: a peptide-mapping LC-HRMS (liquid chromatography-high resolution mass spectrometry) workflow that can identify and monitor multiple product quality attrib...
Focusing on two gene variants obscures the more complex gene relationships that drive obesity. Here’s what we miss if we only focus on one gene variant at a time. The post Obesity...
by Qichen Duan, Sumie Okuwa, Rachel Estrella, Chun Yeung, Yu-Chieh David Chen, Laura Quintana Rio, Chengcheng Du, Khanh M. Vien, Pelin Cayirlioglu Volkan Over the past decades, ma...
A contract manufacturer running multiple adeno-associated virus (AAV) programs says early engagement between key stakeholders, proactive risk assessments and platform knowledge is...
A modular mechanistic modeling framework is helping transform mRNA in vitro transcription by enabling faster optimization, streamlined scale-up, and quality-by-design strategies, g...
A chip production method combines molecular materials with semiconductor manufacturing to build molecular memory and computing devices. Researchers at the Massachusetts Institute o...
To produce stable cell lines for monoclonal antibody production, manufacturers typically use the piggyBac transposon system. For larger, multi-specific antibodies that have payload...
A new mathematical model tracks how plasmids move through competing E. coli populations, revealing how antibiotics, genetic costs, and plasmid loss could shape biotechnology cultur...
In the earliest hours of a sea lamprey embryo’s life, something remarkable happens. As its cells divide, vast stretches of genetic material—entire chromosomes—are...
Through its entry into Lilly Gateway Labs, Rznomics officials say they plan to accelerate candidate discovery and development across its target gene database bank comprising over 2...
Forscher versprachen sich große Erkenntnisse von der Entschlüsselung der DNA, 2001 gelang sie erstmals. Doch bis heute bleiben viele Geheimnisse. mehr...
by Carina F. Mugal, Marie Sémon A new study in PLOS Biology shows that in Drosophila, patterns of molecular evolution differ between genes expressed during oogenesis and spermatog...
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