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RNA sequencing from more than 22 million cells trained a model that predicts cell-type-specific gene expression and noncoding variant...
by Andrea Repele, Joanna Handzlik, Nimasha Samarawickrama, Trevor Long, Sunil Nooti, Veena Potluri, Yen Lee Loh, Manu The differentiation of hematopoietic progenitors into special...
The study identified "gene expression gradients", overlapping chemical signals that give every brain region a unique molecular ID.
Researchers show that gene syntax reshapes DNA supercoiling, amplifying or suppressing neighboring genes. The work uncovers a design rule that could improve the precision and behav...
by Clelia Corridori, Merrit Romeike, Giorgio Nicoletti, Christa Buecker, Samir Suweis, Sandro Azaele, Graziano Martello Physiological and pathological processes are governed by ne...
RNA sequencing captures both coding and noncoding RNAs at single-cell resolution, revealing complex regulatory programs and cellular identities across development and disease...
At the Wellcome Sanger Institute, advances in spatial transcriptomics and RNA sequencing enable detailed mapping of gene expression and cellular interactions within complex tissues...
In a groundbreaking revelation poised to reshape our understanding of fetal development, recent research has illuminated a perplexing biphasic oxygenation pattern during mid-gestat...
by Arman Karshenas, Tom Röschinger, Hernan G. Garcia Despite the sequencing revolution, large swaths of the genomes sequenced to date lack any information about the arrangement of...
by Debomita Chakraborty, Raghunathan Rengaswamy, Karthik Raman A unique balance of seemingly contradictory properties like robustness and plasticity, or evolvability and functiona...
RNA sequencing combined with perturbation data enables PSGRN to improve gene regulatory network inference, enhancing accuracy in identifying gene interactions across single-cell...
RNA sequencing combined with spatial profiling tracks gene expression and cell proliferation, revealing dynamic cellular interactions and uncovering new insights into development.....
by Pjotr L. van der Jagt, Steven Oud, Renske M. A. Vroomans Developmental system drift (DSD) is a process where a phenotypic trait is conserved over evolutionary time, while the g...
RNA sequencing reveals how Sox9 dynamically regulates gene expression during cartilage development, highlighting distinct cell populations and shifting genetic programs...
by Mohita Gaur, Matthew J. Brooks, Xulong Liang, Ke Jiang, Anjani Kumari, Milton A. English, Paolo Cifani, Maria C. Panepinto, Jacob Nellissery, Robert N. Fariss, Laura Campello, C...
RNA sequencing calibration using standardized references enables absolute quantification of gene expression, improving cross-study comparisons and reducing bias across experiments...
Biologists have long puzzled over why organisms with similar numbers of protein-coding genes can differ so dramatically in nervous system complexity. New research points to a poten...
Long-distance gene control first emerged around 650 to 700 million years ago, significantly earlier than scientists had previously believed. Life depends on timing. Every cell must...
In a preprint published in arXiv, researchers from Altos Labs have described a machine learning algorithm that performs end-to-end prediction of how cells’ gene expression will res...
RNA sequencing reveals subtle sex-linked differences in brain gene expression across cell types, offering insight into neurological and psychiatric disease risk and progression...
by Michal Sadowski, Andy W. Dahl, Noah Zaitlen, Richard Border Gene-environment interaction (G × E) studies hold promise for identifying genetic loci mediating the effects of envi...
Spatial biology is a rapidly advancing discipline that examines biological molecules (such as DNA, RNA, and proteins) within their native locations in tissues. This approach offers...
RNA sequencing supports space biology research by enabling transcriptome-wide analysis of gene expression changes associated with spaceflight and adaptation to space environments.....
RNA sequencing with NTVE enables repeated monitoring of gene expression in living cells, supporting time-course analysis of differentiation, perturbation responses, and cellular dy...
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