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Why do some multiple sclerosis patients deteriorate rapidly while others experience mild symptoms for decades? A post-mortem neuro-audit reveals that severe MS progression is linke...
Researchers here note a mechanism that encourages the innate immune cells known as microglia to better clear amyloid-β in the aging brain. The protein PM20D1 acts in the formation...
Microglia are innate immune cells of the central nervous system, analogous to macrophages elsewhere in the body. Overly reactive and senescent microglia are implicated in the devel...
Increasing attention in the research community is being given to age-related dysfunction of microglia in the brain as a contribution to loss of cognitive function and onset and pro...
Astrocytes make up a sizable fraction of the supporting cells of the brain, and undertake a wide range of tasks in order to maintain function. They supply metabolites needed for ne...
All cells release and take up extracellular vesicles. This includes the bacteria present in the body, both the beneficial commensal species resident in various locations such as mo...
Inflammation in the brain is thought to be important in the progression of neurodegenerative conditions, disruptive to cell and tissue function. Understanding why the other feature...
Researchers discovered that dysregulated circadian rhythms cause microglia, the brain’s immune cells, to become "stress-primed" and malfunction. This state prevents them from clear...
In a groundbreaking study poised to redefine our understanding of neurodegenerative diseases, researchers have uncovered compelling evidence linking the expression of caspase-4 wit...
RNA sequencing revealed dysfunctional microglia in multiple system atrophy, providing new insight into immune exhaustion and potential therapeutic targets in this aggressive neurod...
In the ever-evolving landscape of neuroscience, new studies continuously unravel the intricate mechanisms that underlie neurological disorders, providing fresh insights and potenti...
A new study shows that the overexpression of somatostatin (SST), a neuropeptide produced in neurons and acting mostly on microglia, lowers inflammation and amyloid β burden, improv...
Scientists have discovered a way to help the brain clean itself of harmful Alzheimer’s plaques by activating its own support cells. By increasing a protein called Sox9, researchers...
Astrocytes: The Unsung Heroes Behind Cognitive Longevity and Brain Resilience In the quest to unravel the intricate workings of the human brain, astrocytes—star-shaped glial cells—...
Glioblastoma, the most common and most aggressive brain tumor type in adults, remains difficult to treat because it can infiltrate surrounding brain tissue and spread far beyond th...
A preclinical study identifies a precision target to quiet the brain's immune system in Alzheimer’s without disabling its defense against infections.
The brain’s immune cells are supposed to be fighters. In Parkinson’s disease, they are: scan the brain tissue of a Parkinson’s patient and you will find microglia buzzing with infl...
In the relentless quest to unravel the mysteries of neurodegenerative diseases, a groundbreaking study recently published in Cell Death Discovery is shedding new light on a previou...
The tau protein is involved in maintaining stability of microtubule structures in the axons that connect neurons. It isn't the only protein that undertakes this task, and loss of f...
by Abhimanyu Kiran, Peter A. Thomason, David M. Versluis, Peggy I. Paschke, Hannah Donnelly, Luke Tweedy, Sergio Lilla, Isabel Bravo-Ferrer, Amy Shergold, Ryan Devlin, Edward W. Ro...
A new study leverages an elegant genetic engineering technique to track the exact routes metabolic debris uses to exit the central nervous system.
A new study identifies astrocytes as a crucial therapeutic target for Fragile X syndrome, offering hope for treating seizures and sensory issues.
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