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kidney-international.org /4 weeks ago

Communication leading to injury: podocyte-derived fibrillin-1 induces mesangial cell activation and proliferation throug...

The mechanism by which podocyte injury induces mesangial activation, a pathologic hallmark of glomerulosclerosis, is poorly understood. In this issue of Kidney International, He et...

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bioengineer.org /3 weeks ago

CD248 Controls Fibroblast Mechanosensing in Kidney Fibrosis

In a groundbreaking study set to redefine our understanding of renal fibrosis, researchers have identified a novel mechanosensory role for the protein CD248 in fibroblast subpopula...

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fightaging.org /3 weeks ago

Inhibiting ID1 and ID3 Reduces Lung Fibrosis

Lung fibrosis is challenging to treat and largely irreversible. There have been signs that clearance of senescent cells can improve the condition, but this has yet to move beyond e...

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bioengineer.org /1 week ago

Targeting S100A4–TLR4–TGF-β Axis in Diabetic Dupuytren’s

In a groundbreaking study published in Cell Death Discovery, researchers have unveiled a complex molecular pathway that may pave the way for transformative therapeutic strategies t...

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bioengineer.org /1 month ago

Boosted WNT10B/FOXO6 Drives Kidney Inflammation, Fibrosis

A groundbreaking new study unveils critical insights into the molecular pathways driving renal inflammation and fibrosis, conditions that pose significant challenges in chronic kid...

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bioengineer.org /1 month ago

Hydrogel with AAV8-sTβRII Reduces Skin Scars

In the quest to transform wound healing and reduce the chronic burden of scarring, a groundbreaking gene therapy approach has emerged, combining cutting-edge biomaterials with prec...

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bioengineer.org /3 weeks ago

Catecholaminergic Neurons Enhance Keloid Fibroblast Bone Growth

In a groundbreaking study set to transform our understanding of fibrotic skin disorders, researchers have uncovered a novel cellular interaction driving the abnormal bone-like tiss...

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kidney-international.org /1 month ago

A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease

The maintenance of a healthy epithelial-endothelial juxtaposition requires crosstalk within glomerular cellular niches. Here, we sought to understand the spatially anchored regulat...

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bioengineer.org /1 month ago

CNIO Study Paves the Way for Personalized Liver Fibrosis Therapies

Liver fibrosis is a common pathological feature underlying a wide spectrum of chronic liver diseases and acts as a precursor to cirrhosis, an irreversible and often fatal condition...

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bioengineer.org /1 month ago

Dual Protein Inhibition Reverses Lung Scarring in Preclinical Study

In a groundbreaking development poised to transform the therapeutic landscape for idiopathic pulmonary fibrosis (IPF), researchers at Virginia Tech’s Fralin Biomedical Research Ins...

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bioengineer.org /1 month ago

Engineered Dendritic Cells Prevent Cardiac Remodeling

Heart failure, a devastating condition characterized by the heart’s inability to pump blood efficiently, remains a leading cause of global morbidity and mortality. Despite advances...

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genengnews.com /1 month ago

“Click Clotting” Technique Rapidly Creates Stronger Blood Clots

Researchers developed “click clotting,” as a method to link red blood cell surface proteins through a chemical reaction, offering a fast way to create biocompatible engineered bloo...

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bioengineer.org /1 week ago

Deep Phenotyping Reveals Skin Remodeling in Sclerosis Treatment

In a remarkable stride toward combating systemic sclerosis, an aggressive connective tissue disease marked by skin thickening and fibrosis, a team of researchers has unveiled groun...

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news-medical.net /1 week ago

Biomimetic nanocomposite hydrogel promotes tendon healing and tissue regeneration

The new system, termed KGN@PB@CM, combines several advanced elements. Prussian blue (PB) nanozymes act as potent reactive oxygen species (ROS) scavengers, while kartogenin (KGN)-a...

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scienceblog.com /2 days ago

The Molecule Our Own Cells Make That Could Finally Help Treat Drug-Resistant Rheumatoid Arthritis

Your immune system, when it turns against you, does so methodically. In rheumatoid arthritis the synovial membrane, that thin lining cushioning every joint, becomes something else...

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orthospinenews.com /1 month ago

MTF Biologics® and Kolosis BIO® Launch the Latest Addition to the DBX Family: DBX® Fiber

DBX portfolio expands with fiber tissue form, processed for addressing complex fusion environments EDISON, N.J. & SALT LAKE…

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bioengineer.org /1 month ago

Gene Expression in Cord Blood: Toward Artificial Placenta

In a groundbreaking revelation poised to reshape our understanding of fetal development, recent research has illuminated a perplexing biphasic oxygenation pattern during mid-gestat...

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ryortho.com /1 day ago

Autograft’s Quiet Crew May Be Doing the Fusion Work

Iliac crest autograft may not win because mature bone cells survive the trip. It may win because the right progenitors DO.

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bioengineer.org /1 month ago

Fibroblast Lipids Drive Epithelial Cancer Invasion Rates

In a groundbreaking advancement that could redefine how we understand and combat oral squamous cell carcinoma (oSCC), researchers have unearthed pivotal roles for tissue-specific f...

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genengnews.com /1 month ago

Regenerative Medicine: Promise, Hype, and What Actually Works

Regenerative therapy is any treatment therapy that improves tissue health or function. With that definition, we can include platelet-rich plasma (PRP), stem cells, and autologous c...

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bioengineer.org /3 weeks ago

Btg2 Blocks Fmo1 UFMylation, Worsens Liver Injury

A groundbreaking study recently published in Nature Communications has unveiled a novel molecular pathway that worsens liver damage during ischemia-reperfusion injury (IRI), a cond...

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fightaging.org /4 days ago

An Update on Progress at Repair Biotechnologies, Developing Means to Regress Atherosclerotic Plaque

Atherosclerosis is the development of fatty plaques that narrow blood vessels and eventually rupture to cause a stroke or heart attack, the most common cause of human mortality. At...

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fightaging.org /1 month ago

BCL-2 and Cellular Senescence in Pulmonary Fibrosis

Cellular senescence has been increasingly implicated in the development of pulmonary fibrosis, a largely irreversible condition with a poor prognosis under the current standard of...

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dentistry.co.uk /3 weeks ago

Could wool replace collagen in guided bone regeneration?

Researchers at King’s College London’s Faculty of Dentistry, Oral and Craniofacial Sciences have developed a keratin-based membrane derived from wool that could offer a more struct...

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