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Traditional gene editing rewrites DNA. But a new approach, called epigenome editing, aims to treat the molecular scars we collect throughout our lives.
Here is yet another clue about how we are both spiritual and physical beings. The two realms are connected in mysterious and remarkable ways. Source
Scientists linked early-life stress experience in mice to long-term stress hypersensitivity within the brain’s dopaminergic circuitry, providing a mechanism by which early-life str...
Every mechanism of aging influences all of the other mechanisms of aging. Our biology is a big tangled ball of interactions. As a follow up to a recent post on the connection betwe...
DNA regulatory elements, which control when, where, and to what extent specific genes are turned on or off, can be co-opted by scientists to create gene switches. The post Gene Sw...
A new study has found that the signals cells use to switch genes on have remained almost unchanged across two billion years of evolution, but the ones used to switch genes off vary...
Maternal age effects may arise from reversible epigenetic changes whose impact depends partly on genetics and evolutionary pressures. A mother’s age can leave a biological imprint...
Chromatin, the molecular packaging system that compacts DNA inside the nucleus, is not merely a passive storage device. By loosening or tightening access to genetic material, it he...
Single-cell RNA sequencing identified an electromagnetic field-responsive gene, enabling researchers to develop a reversible switch for precise, non-invasive control of gene expres...
Because we are dealing with foundational scientific discoveries, we will address several “So what?” questions. Source
In the earliest hours of a sea lamprey embryo’s life, something remarkable happens. As its cells divide, vast stretches of genetic material—entire chromosomes—are...
A mouse study suggests that changes in DNA packaging can create a molecular memory of trauma that makes the brain more vulnerable to future stress. Severe stress in childhood can l...
StackRSS Canonical Source Context Original Article Title: Methylation puts parasites in motion Journal or Source Feed: Eurekalert | Biology Original Publication Date: Not provided...
Epigenetics and family patterns are not fate.
Nearly every cell in the human body contains essentially the same genetic information, yet different cells activate different genes. For regulatory proteins to reach these genes, D...
Changing what you eat may begin reshaping how your genes behave in as little as a few weeks, even though your DNA itself remains unchanged. In a randomized clinical trial, research...
Story at-a-glance Millions of adults in the U.S. fail to meet their daily dietary fiber requirements, a fact that often goes unnoticed until serious health issues emerge. According...
Epigenetic fingerprints may help explain how environmental exposures contribute to colorectal cancer in people under 50. Why is colorectal cancer becoming more common in people und...
A new study has found that heavy fishing may be changing pearly razorfish at the molecular level. Researchers found no major changes in the fish's DNA but discovered differences in...
Crosstalk between mitochondrial metabolism and epigenetic regulation helps activate the inflammatory SASP in senescent cells, revealing a potential therapeutic target for limiting...
Atlases like this one can provide the labeled, cell-type-resolved training data that artificial intelligence models need to make accurate predictions—a bottleneck that has historic...
A new study reveals that the human brain undergoes major shifts in 3D genome architecture and gene regulation starting in midlife.
Researchers identified molecular circuits that lock cells into abnormal states and developed a way to reset them, opening new possibilities for aging and cancer research.
by Luisa Quesada Camacho, Mohammad Fallahi-Sichani Epigenetic dysregulation is a common feature of cancer. It creates vulnerabilities arising from an increased reliance on chromat...
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