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bioengineer.org /1 month ago

CRISPR Methylation Editing Rewrites the Cancer Epigenome Toward Causation

Cancer has long been understood as a disease of the genome, driven by mutations that rewire the instructions encoded in DNA. Over the past three decades, however, a parallel truth...

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nytimes.com /1 month ago

A Newer Kind of Gene Editing Promises to Edit ‘Nurture’ Over ‘Nature’

Traditional gene editing rewrites DNA. But a new approach, called epigenome editing, aims to treat the molecular scars we collect throughout our lives.

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journals.plos.org /2 weeks ago

The histone methyltransferase complex subunit RBBP5 serves as a central epigenetic regulator of proteostasis dynamics

by Syeda Kubra, Michelle Sun, William Dion, Yu Bian, Ahmet Catak, Hannah Luong, Haokun Wang, Yinghong Pan, Jia-Jun Liu, Aishwarya Ponna, Lijun Liu, Ian Sipula, Jian-Hua Luo, Michae...

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genengnews.com /2 weeks ago

The Epitranscriptome Heads Toward Clinical Necessity

Short-read RNA sequencing reporting the modifications that alter protein output is starting to make epitranscriptomics indispensable for patient selection in precision medicines. T...

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fightaging.org /3 days ago

The Polycentric Aging Framework Positions Epigenetic Change as the Dominant Mechanism of Aging

The presently available data and understanding of aging might be thought of as a jigsaw with more missing pieces than there are pieces in hand. There is a great deal of latitude to...

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journals.plos.org /2 weeks ago

Epigenetic maintenance of PRC2-repressed chromatin requires RTT109 but not H3K56 acetylation

by Rochelle E. Yap, Felicia Ebot-Ojong, Abigail J. Ameri-Solanky, Zachary A. Lewis In animals, plants, and some fungi, Polycomb Repressive Complex 2 (PRC2) catalyzes trimethylatio...

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scitechdaily.com /1 month ago

Your Mother’s Age May Leave a Biological Mark That Lasts for Generations

Maternal age effects may arise from reversible epigenetic changes whose impact depends partly on genetics and evolutionary pressures. A mother’s age can leave a biological imprint...

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genengnews.com /2 weeks ago

Epigenetics Underlies Comparatively Accelerated Molecular Aging in Larger and Male Dogs

Large dogs tend to be shorter lived than their smaller counterparts, and a new study found that male and larger dogs undergo accelerated molecular aging, with pronounced DNA methyl...

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bioengineer.org /1 month ago

Sea lamprey embryo studies reveal roles of histone methyltransferases in DNA elimination

In the earliest hours of a sea lamprey embryoРІР‚в„ўs life, something remarkable happens. As its cells divide, vast stretches of genetic materialРІР‚вЂќentire chromosomesРІР‚вЂќare...

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scitechdaily.com /3 weeks ago

Scientists Discover a Molecular “Memory” That Could Make Lost Weight Come Back

Obesity may leave behind a cellular memory that pushes the body to regain lost weight. Researchers at the Harrington Discovery Institute at University Hospitals and Case Western Re...

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bioengineer.org /1 month ago

Methylation puts parasites in motion

StackRSS Canonical Source Context Original Article Title: Methylation puts parasites in motion Journal or Source Feed: Eurekalert | Biology Original Publication Date: Not provided...

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fightaging.org /5 days ago

Life Biosciences Reports Initial Results from the First Reprogramming Trial

Partial epigenetic reprogramming involves exposing cells to some or all of the Yamanaka factors for a long enough period of time to reset epigenetic decorations on nuclear DNA and...

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nanowerk.com /4 weeks ago

A single temporary stimulus can redirect cell fate without permanent gene control

A new computational framework that identifies minimal temporary gene-control interventions to steer cells toward desired states while preserving cellular plasticity.

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conservativedailynews.com /2 weeks ago

The Mystery Why Many Diets, Weight Loss Drugs Fail May Be Solved, New Study Suggests

by Libby Bandelin at CDN - New epigenetic research reportedly suggests that the reason many diets and weight loss drugs fail is because fat cells retain memory of an obese state,...

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scitechdaily.com /1 month ago

Human Sperm Is Rewriting DNA Earlier Than We Realized

Some of the genetic differences that make every child unique may arise in a father’s sperm years earlier than scientists thought. Researchers have discovered that some genetic resh...

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genengnews.com /2 weeks ago

DNA Typewriter, PEtracer Map Mouse Development Through Organogenesis

Two DNA-recording systems traced cellular family trees across mouse embryogenesis, offering new insight into how organs form and when developing cells commit to specific fates. The...

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singularityhub.com /2 weeks ago

Epigenetic Editing Could Wipe Out Chronic Hepatitis B Infections

An experimental therapy kept the virus at bay for at least six months. The approach could target other stubborn viruses too. The post Epigenetic Editing Could Wipe Out Chronic Hepa...

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journals.plos.org /1 month ago

Systematic multivariate analysis of chromatin complex dependencies reveals Set1C/COMPASS as a melanoma-enriched epigenet...

by Luisa Quesada Camacho, Mohammad Fallahi-Sichani Epigenetic dysregulation is a common feature of cancer. It creates vulnerabilities arising from an increased reliance on chromat...

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bioengineer.org /3 days ago

AML epigenetic therapies face network-driven resistance, review finds

A comprehensive review finds that AML cells commonly overcome epigenetic drugs through compensatory chromatin and transcriptional adaptation, favoring biomarker-selected combinatio...

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genengnews.com /2 weeks ago

Secrets of Oldest Land Animal’s 194-Year Lifespan Revealed with Epigenetics

Researchers studying a giant tortoise named Jonathan—who is the oldest known living land animal in the world today—say it’s not just good genes, but a lack of genetic wear and tear...

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bioengineer.org /2 weeks ago

Where a Gene Sits on the Bacterial Chromosome May Shape Its Expression Through Selection

A new PLOS Genetics study finds that bacterial gene positions along the chromosome show gradients in mean and growth-dependent expression consistent with selection shaped by replic...

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fightaging.org /3 weeks ago

Accelerated Epigenetic Aging Correlates with Later Loss of Memory Function

Aging clocks have yet to fulfill their promise, which is to produce a robust measure of biological aging that can be used to rapidly assess the results of potential therapies to sl...

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bioengineer.org /3 days ago

Regulatory Evolution Offers Clues to Horn Diversification in Beetles

A comparative study in two beetle species links evolving regulatory DNA and condition-specific chromatin changes to horn diversification, with functional evidence for two BMP-pathw...

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