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In Aging Cell, researchers have described the differences between primary and secondary senescent cells, comparing radiation-induced senescence to senescence induced […]
Dysfunction in the cells making up the inner lining of blood vessels, the vascular endothelium, is thought to be an important first step in the aging of the vasculature more genera...
The burden of lingering senescent cells grows with age in tissues throughout the body. Cells enter the senescent state constantly, but the pace of clearance of senescent cells by t...
Chronic kidney disease is largely age-related, though can occur in younger people under some circumstances. It is one of a number of conditions in which research strongly implicate...
Increasing attention in the research community is being given to age-related dysfunction of microglia in the brain as a contribution to loss of cognitive function and onset and pro...
Cellular senescence has been increasingly implicated in the development of pulmonary fibrosis, a largely irreversible condition with a poor prognosis under the current standard of...
Senescent cells accumulate with age, but not all senescent populations are equal. Evidence suggests that some types of senescent cell cause more harm than others, and the research...
In a groundbreaking breakthrough that promises to redefine therapeutic strategies for cancer and aging-related diseases, researchers from the MRC Laboratory of Medical Sciences (LM...
Researchers identified GPX4 inhibitor drugs that target a defense mechanism in senescent cells, and which could lead to new treatments for cancer and age-associated diseases. The...
A burgeoning field is launching its first clinical trial to find out whether dialing back cell development can safely refresh aged tissues and organs
Scientists uncover a metabolic vulnerability in aging cells that could be key to restoring resilience and combating age-related diseases. As people grow older and become more frail...
Sleep apnea is correlated with cardiovascular disease, among other conditions. It induces a state of hypoxia in tissues when regular breathing is interrupted. Here, researchers ind...
A team of scientists has examined how younger and older mice heal from wounds and found that more robust senescent cell activation in younger animals helps them heal faster. A doub...
Scientists are uncovering a surprising truth about aging cells: some may damage the body, while others help protect it. The discovery is fueling a new wave of precision anti-aging...
Researchers have discovered that the "cell death" protein MLKL actually causes blood stem cells to age by damaging their mitochondria. Deactivating this pathway could lead to new t...
For most of human history, cellular aging was treated as biologically fixed, an inevitable accumulation of damage with no meaningful pathway to reversal. That assumption is no long...
The aging of the adaptive immune system, made up of B cells and T cells, is a complex process. Broadly, the pace at which new adaptive immune cells are created declines to a tiny f...
Aging is a complex and multifaceted process marked by gradual biological transformations that affect virtually all cells within the body. Despite decades of research, much about ho...
A newly identified weakness in “zombie” cells may open the door to more precise cancer treatments by turning their own survival strategy against them. A new class of drugs takes ad...
As we age, our bodies lose some resilience, which can lead to less movement throughout the day and an increased risk of facing multiple chronic diseases at once (multimorbidity). T...
As the understanding of more recently discovered modes of programmed cell death are fleshed out, they receive greater attention from various groups focused on specific aspects of a...
by Priscila Chiavellini, Vittorio Sebastiano Aging is typically framed as a one-way, irreversible accumulation of molecular damage in cells and tissues, leading to progressive fun...
Presently largely irreversible lung disease like idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease were one of the first conditions targeted for the developme...
Biological age is becoming critically important to gauge a person’s overall health. It is a more accurate predictor of disease risk, healthspan (years lived disease-free),...
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