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Cancer immunotherapy is entering a more controlled and technically sophisticated phase, according to a wide-ranging collection of studies and reviews that outline how researchers a...
Mumbai (Maharashtra) [India], October 12: For much of the past two decades, immunotherapy was thought of as a treatment held in reserve — an option to try after chemotherapy and ra...
Most people have heard of cancer immunotherapy by now. These treatments help a patient’s own immune system recognize and attack cancer. The best-known examples are immune checkpoin...
A short course of immunotherapy before surgery may offer remarkably durable protection for some patients with stage two or three bowel cancer. In the NEOPRISM-CRC trial, 32 patient...
Pre-surgery immunotherapy kept a group of bowel cancer patients cancer-free for nearly three years, while personalized blood tests helped predict treatment response. Patients with...
Immunotherapy has transformed the treatment landscape for non-small cell lung cancer, the most common form of lung malignancy worldwide, yet a stubborn problem persists: only a sub...
High-risk neuroblastoma is one of the most aggressive forms of solid tumors affecting children, originating in the nervous system. While a newer class of targeted immunotherapy dru...
One of the most stubborn obstacles in cancer immunotherapy is not the tumor cell itself but the cellular entourage that surrounds it. In hepatocellular carcinoma, the most common f...
Researchers at Purdue University have developed a small-molecule compound that could open a new route toward cancer immunotherapy by targeting a protein that normally restrains imm...
Radiotherapy may do more than destroy cancer cells at the site of treatment: it can also alert the immune system to the tumor. Yet that alarm is often too faint, too brief, or too...
Christopher Burston’s bowel cancer appeared to disappear after just nine weeks of immunotherapy, yet he still underwent surgery. The British patient, diagnosed with stage III bowel...
Single-cell analysis of 56 glioblastoma tumors reveals that T-cell-rich cases harbor clonally expanded, LAG3-high CD8 T cells that may be tumor-reactive, opening new avenues for im...
Scientists are on the cusp of fulfilling a decades-long quest: to use vaccines to teach the immune system to spot and destroy cancer cells. News that an mRNA cancer vaccine develop...
The immune system is full of T cells that could hunt down and destroy tumors, if they were primed. Now, a UC San Francisco team has invented a way to do this by combining immune ce...
Blocking an antioxidant protein that tumors use to suppress immune attacks improved cancer immunotherapy responses in mice. Cancer cells can release antioxidants that interfere wit...
The treatment can reprogram immune cells that have been corrupted by the cancer, strengthening the body’s ability to attack.
A new review reveals how the unfolded protein response, a cellular stress-signalling network, helps tumours evade immune detection and could be targeted to boost cancer immunothera...
A HER2-targeted mRNA lipid nanoparticle vaccine combined with fractionated radiotherapy suppressed tumor growth and reprogrammed the immune microenvironment in a mouse model of HER...
Pancreatic tumors vanished in roughly half of mice given an experimental mRNA therapy and did not return for up to a year after treatment stopped. Researchers at UMass Chan Medical...
A new report in the New England Journal of Medicine by researchers at Baylor College of Medicine, Texas Children's Hospital and Seattle Children's describes a complete regression o...
Targeted lipid nanoparticles deliver mRNA to tumor-associated macrophages, reprogramming the immune environment and strengthening anti-cancer T-cell activity in mice.
The GSK cancer immunotherapy Jemperli is now approved for treating advanced cases of rectal cancer harboring a particular genetic signature. It’s a label expansion for Jemperli, wh...
Polymer-based nanomedicines could reshape the tumor microenvironment, helping immune cells attack resistant cancers and potentially improve immunotherapy.
An overlooked population of immune cells could offer a new way to attack one of the deadliest forms of lung cancer.Continue ReadingCatego...
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