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Blood tests to assess Alzheimer's disease risk and progression exist, for example based on the presence of circulating varieties of tau protein, but there is a great deal of room f...
by Asgeir Kobro-Flatmoen, Jagir R. Hussan, Peter J. Hunter, Stig W. Omholt The entorhinal cortex (EC) plays a crucial role in memory functions. Long before the clinical symptoms o...
A recent case report published in JAMA has shed new light on the mechanisms involved in amyloid clearance following amyloid-targeting therapies for Alzheimer’s disease. This ground...
Researchers have uncovered a possible reason why the Alzheimer’s risk gene APOE4 can disrupt the brain long before memory problems begin. In mice, APOE4 increased a protein called...
Researchers here suggest that increased ERBB4 expression in neurons is an important driving mechanism in the onset and progression of Alzheimer's disease. One has to be cautious wi...
A never-before-seen amyloid fold linked to the Flemish APP mutation may explain why amyloid-beta targets blood vessels in a rare The post A Rare Alzheimer’s Mutation Just Revealed...
An experimental Alzheimer’s compound prevented damaging protein clumps from forming in the brains of mice, helping nerve cells survive longer and reducing amyloid buildup. The trea...
A number of neurodegenerative conditions, including Alzheimer's disease, are characterized by a pervasive chemical alteration of tau protein that causes tau to cease its normal fun...
Clearing amyloid plaques may break the chain reaction that fuels brain cell destruction in Alzheimer’s disease. One Alzheimer’s brain offered researchers something they almost neve...
A new study in Nature Neuroscience reports that changes in the thickness of the cerebral cortex can appear at least seven years before amyloid reaches high levels in the brain, cha...
Alzheimer's just gave up another one of its secrets.ScienceAlert stories are written, fact-checked, and edited by humans, never generated by AI. Don't miss a story, subscribe here.
The discovery of a new seed of the amyloid beta protein could lead to early-stage therapy for neurodegenerative disease, according to researchers.
The first predictive blood tests for future risk of Alzheimer's disease were developed in recent years based on correlations between marker proteins in the blood and disease risk d...
A protein thought to play a critical role in the progression of Alzheimer’s disease may not originate where scientists thought, according to a recent study out of Columbia Universi...
Many of the more sophisticated forms of medicine, including gene therapies and immunotherapies, are challenging to deliver to the brain. At the very least there are far fewer pract...
Researchers say the oral drug LM11A-31 slowed the decline of brain-network function in a small trial, pointing to a potential broader strategy for treating Alzheimer’s.
A protein called SORLA may act as a powerful defense against the toxic tau tangles involved in Alzheimer’s disease. Mice with extra SORLA had less tau accumulation, less brain atro...
Breaking the feedback loop.ScienceAlert stories are written, fact-checked, and edited by humans, never generated by AI. Don't miss a story, subscribe here.
The longevity-linked APOE2 gene appears to protect brain cells by reducing DNA damage and helping neurons recover from stress. The finding could open a new path toward treatments t...
Biogen's leading tau-targeting candidate has slowed cognitive decline across a suite of different clinical assessments, backing up the pharma’s decision to race the molecule into p...
Exosomes are one category of extracellular vesicle secreted by cells, a membrane-wrapped package of molecules, one complex component of the extensive, incompletely mapped communica...
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