Social Media Ideas for Amyloid-Ss

Amyloid-β Seeding as a Basis for a Blood Test for Alzheimer's Disease

Blood tests to assess Alzheimer's disease risk and progression exist, for example based on the presence of circulating varieties of tau protein, but there is a great deal of room f...

Scientists may have overlooked a hidden Alzheimer's culprit for decades

For decades, scientists have focused on amyloid beta as a major culprit behind Alzheimer’s disease, spending billions of dollars developing treatments that have often delivered dis...

Scientists Thought This Peptide Was Harmless. A New Discovery Could Rewrite Alzheimer’s Research

Lab research suggests the little-studied peptide can form amyloid clumps and may damage neurons, but its role in Alzheimer’s patients remains unproven.

APOEОµ2 Pericytes Provide a More Resilient Blood-Brain Barrier

Why is the APOEОµ2 variant of the APOE gene associated with a lower risk of Alzheimer's disease and slightly longer life expectancy? Past research has investigated the role of APOE...

The APOEОµ4 Variant Interferes in Myelination in the Aging Brain

Of the common variants of the APOE gene, APOEОµ4 presents the greatest risk of Alzheimer's disease. APOE is involved in lipid metabolism, and APOEОµ4 is associated with lipid-relat...

Scientists Identify a Potential New Alzheimer’s Disease Marker

The fluid surrounding the brain may hold another clue to Alzheimer’s, with elevated levels of an enzyme called meprin-β raising the possibility of a new disease indicator. One of t...

Suggesting ERBB4 Overexpression as an Important Mechanism in Alzheimer's Disease

Researchers here suggest that increased ERBB4 expression in neurons is an important driving mechanism in the onset and progression of Alzheimer's disease. One has to be cautious wi...

Antibody Blocks T Cell Infiltration and Limits Neurodegeneration in Alzheimer’s Mice

Researchers developed a potential antibody-based approach to reducing neurodegeneration in tauopathies, with studies showing that in a mouse Alzheimer’s model anti-CXCR3-treated an...

The Peptide Catestatin Reduces Tau Pathology in Mice

Later stages of Alzheimer's disease and other tauopathies are characterized by the aggregation of altered tau protein, and a toxic surrounding biochemistry that provokes inflammati...

<![CDATA[Beyond Amyloid, Part Two (of two): Delivery, Diagnostics and the Path to Combination Care]]>

Rare study reveals a striking divide inside an Alzheimer’s patient’s brain

A rare examination of an Alzheimer’s patient’s brain revealed that regions cleared of amyloid plaques had remarkably little of the harmful tau buildup associated with memory loss,...

1 in 5 People Carry This Alzheimer’s Risk Gene. The Damage May Start Decades Before Memory Loss

Columbia researchers found that excess fibronectin make brain blood vessels leak decades before symptoms of cognitive decline appear. It occurs in people with one particular gene.

How Alzheimer’s Risk Gene APOE4 Disrupts Myelination

Study linked the APOE4 gene with suppression of Wnt signaling in the oligodendrocyte cells that provide neurons with their fatty myelin insulation, and also demonstrated a potentia...

A Little-Known Protein Could Point to a New Way To Treat Alzheimer’s

A study suggests that increasing SORLA protein levels could help treat Alzheimer’s disease and other disorders involving tau protein. Increasing SORLA, a protein with a protective...

Beyond amyloid and tau: A perspective on the impact of α-synuclein in Alzheimer’s disease

Another new publication! Congratulations Dr. Abbas Babajani-Feremi on the publication of “Beyond amyloid and tau: A perspective on the impact of α-synuclein in Alzheimer’s disease,...

Origins of Alzheimer's protein challenges assumptions on disease

A protein thought to play a critical role in the progression of Alzheimer’s disease may not originate where scientists thought, according to a recent study out of Columbia Universi...

Targeted Reduction of PTBP1 Reverses Cognitive Impairment in a Mouse Model of Alzheimer's Disease

Many of the more sophisticated forms of medicine, including gene therapies and immunotherapies, are challenging to deliver to the brain. At the very least there are far fewer pract...

Beyond ALS: Misfolded SOD1 Emerges as a Shared Player in Brain Disease

A sweeping review of human neuropathological evidence shows that misfolded SOD1, long tied to familial ALS, coexists with TDP-43, tau, alpha-synuclein, and amyloid-beta across mult...

Microprotein Atlas Links Brain Immune Cell Dysfunction to Alzheimer’s

Built from transcriptomic and mass spectrometry data, the atlas uncovered more than 1,000 previously uncharacterized microproteins and pointed to a potential connection between one...

Does perturbed adaptive myelination contribute to cognitive dysfunction in Alzheimer’s disease?

by Charles ffrench-Constant The consequences of oligodendrocyte involvement in Alzheimer’s disease are poorly understood. Could a key role of gray-matter oligodendrocytes—activity...

Alzheimer’s-related proteins can show up in blood in midlife — but a result is not the same as a diagnosis

Alzheimer’s disease is usually imagined as a disease of old age. The biology behind it can begin much earlier, potentially years or decades before memory problems become obvious. A...

Experimental Arrowhead RNAi drug hints at Alzheimer’s benefit

In a first, a subcutaneously administered RNA interference medicine crossed into the brain and plummeted levels of a protein implicated in the disease.

The State of Development for Therapies to Treat Tauopathies

The major neurodegenerative conditions are characterized by pathology deriving from a small number of misfolded or otherwise altered proteins. Amyloid-β misfolding and aggregation...

Alzheimer’s risk gene APOE4 may have a reversible weakness

The Alzheimer’s risk gene APOE4 may actively damage brain blood vessels and sabotage the cellular systems that remove harmful proteins. Researchers were able to reverse some of the...