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Scientists have demonstrated how cancer cells influence neighboring cells to create a favorable niche for the tumor to grow. Understanding this can inform future early-stage cancer...
STING is a master regulator of inflammatory signaling, triggered by a range of different sensor proteins for foreign material or forms of damage within a cell. With age, these sens...
Neurons and glial cells utilize a specialized metabolic mechanism centered on leucine-derived acetyl-coenzyme A (AcCoA) to regulate the master growth hub, mTORC1.
Nucleic acids such as DNA and RNA should in the normal course of events largely remain localized within the cell nucleus and mitochondria, the locations of the nuclear genome and m...
The accumulation of senescent cells in aged tissues is harmful because these cells generate a potent mix of inflammatory signals known as the senescence-associated secretory phenot...
Structural alterations within the cerebellar extracellular matrix serve as primary drivers of autism-related circuit dysfunction.
Researchers here identify mechanisms downstream of faulty calcium metabolism that drive the harmful signaling of senescent cells that accumulate in aged tissues. Calcium metabolism...
In a groundbreaking study set to reshape our understanding of metabolic diseases, researchers have uncovered a pivotal mechanism linking the impaired differentiation of adipocytes...
In a groundbreaking study published in Nature Communications, researchers have unveiled a critical molecular pathway by which the gut’s barrier function is compromised in a conditi...
The gut microbiome generates a vast range of metabolites, some beneficial or even necessary to health, and some actively harmful, provoking chronic inflammation or other dysfunctio...
Cancer cells have long been notorious for their ability to evade therapeutic attacks, often slipping into a dormant state where they are less susceptible to conventional drugs. Thi...
Macrophages are innate immune cells found throughout the body, important not just for their ability to defend against infectious pathogens, but also deeply involved in tissue maint...
That part of the life science research community focused on better understanding and treating the panoply of age-related neurodegenerative conditions is increasingly focused on chr...
Mitochondrial function is clearly important in the development of Parkinson's disease. The mutations associated with increased risk of Parkinson's are related to mitochondrial qual...
by Martin Lardy, Leqi Wang, Claire Guerrier, Veronica T. Cheli, Pablo M. Paez, Anmar Khadra Calcium (Ca2+) signaling has emerged as a central regulator of activity-dependent myeli...
Brain-infiltrating γδ T cells accumulate in a genetic autism mouse model, contributing to social deficits. Removing or blocking these immune cells improved sociability, highlightin...
Every mechanism of aging influences all of the other mechanisms of aging. Our biology is a big tangled ball of interactions. As a follow up to a recent post on the connection betwe...
In an extraordinary revelation poised to reshape our understanding of cellular maintenance and survival strategies, a groundbreaking study published in Nature Communications unveil...
The gut microbiome is made of thousands of microbial species, many of which conduct activities necessary to health. Our tissues have evolved to at least somewhat rely upon the mole...
In a groundbreaking study poised to reshape our understanding of achalasia, researchers have identified a critical genetic variant that triggers autoimmune responses leading to thi...
by Laura Chastant, Karine Normandin, Firas El-Mortada, Marc J. Servant, Vincent Archambault Cellular damage or stress can lead to disorganization, mislocalization or damage to sel...
Nanoscale Horiz., 2026, Accepted ManuscriptDOI: 10.1039/D6NH00215C, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported L...
by Hangyu Liao, Jun Yang, Lei Cai, Luhao Chi, Chunming Wang, Yuyan Xu, Juncheng Xie, Kunling Chen, Jingyuan Pei, Zesheng Jiang, Mingxin Pan, Liang Zhao Crosstalk between hepatocel...
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