Search results for Altered Intercellular Communication

Intercellular Communication via Condensate Corona-Nanoparticle Complexes

New research data suggest that condensate corona–nanoparticles function as an encoded biomolecular transfer program that are activated by the recipient cell, allowing transfer of f...

Signal Reprogramming as an Approach to the Challenge of cGAS-STING Overactivation

Cells in aged tissues suffer a range of biochemical dysfunctions; broken proteins, altered structures, leakage of materials from one compartment to another. Many of these issues pr...

Early Cancer Cells Change Their Surroundings to Form Tumors

Scientists have demonstrated how cancer cells influence neighboring cells to create a favorable niche for the tumor to grow. Understanding this can inform future early-stage cancer...

Communication leading to injury: podocyte-derived fibrillin-1 induces mesangial cell activation and proliferation throug...

The mechanism by which podocyte injury induces mesangial activation, a pathologic hallmark of glomerulosclerosis, is poorly understood. In this issue of Kidney International, He et...

Neuronal AcCoA Signaling Linked to Autophagy Defects in Alzheimer’s

Neurons and glial cells utilize a specialized metabolic mechanism centered on leucine-derived acetyl-coenzyme A (AcCoA) to regulate the master growth hub, mTORC1.

An Approach to Reduce Harmful Inflammation without Greatly Compromising the Normal Immune Response

Excessive, constant inflammation in response to aspects of one's own cellular biochemistry is a feature of both autoimmune disease and aging. While transient inflammation is necess...

Immunotherapy Enhanced by Restoring Mitochondrial Function in Dendritic Cells

A new metabolic mechanism describes how tumors disable immune “gatekeeper” cells in the presence of cancer. Study shows that boosting mitochondrial function in dendritic cells enha...

INS-17 acts as a nutrient deprivation signal to mediate adult IIS-regulated associative behaviors in <i>C. elegans...

by Emily J. Leptich, Priyadharshini Vijayakumar, Edward W. Pietryk, Meredith I. Williams, Rachana Rajupalem, Rachel N. Arey Insulin/Insulin-like growth factor 1 (IGF-1) signaling...

Study finds key factor in cancer treatment failure

A new study by Israeli researchers has discovered a major biological process that explains why some treatments for cancer and other serious diseases do not always work as expected,...

Angptl4 Links Diet, Microbes to Gut Barrier Breakdown

In a groundbreaking study published in Nature Communications, researchers have unveiled a critical molecular pathway by which the gut’s barrier function is compromised in a conditi...

Disruption of the Integrator Responsible for RNA 3′ End Processing Slows Aging in Nematodes

Researchers have established a number of interventions in short-lived species that extend life as a result of degrading the function of a cellular component, usually the mitochondr...

Affecting a Signaling Pathway Alleviates Alzheimer’s in Mice

A new study shows that the overexpression of somatostatin (SST), a neuropeptide produced in neurons and acting mostly on microglia, lowers inflammation and amyloid β burden, improv...

A Mechanism Linking Protein Aggregation to STING Activation and Inflammation in the Aging Brain

Inflammation in the brain is thought to be important in the progression of neurodegenerative conditions, disruptive to cell and tissue function. Understanding why the other feature...

Neural Hotwire: How Biological Synapses Bypass Broken Brain Links

Can we "hotwire" the brain to fix neurological disorders? Researchers have unveiled LinCx, a technology that creates biological electrical "bypasses" between neurons. By engineerin...

Research Finds This Dysfunction Could Be Fueling Alzheimer's Risk

It opens up a new pathway to treatment.

Dynamic cholinergic signaling differentially desynchronizes cortical microcircuits dependent on modulation rate and netw...

by Sibi Pandian, Scott Rich Acetylcholine (ACh) affects both the intrinsic properties of individual neurons and the oscillatory tendencies of cortical microcircuits by modulating...

Single-Cell Map Reveals Immune Crosstalk in Cholangitis

In a groundbreaking study reshaping our understanding of immune interactions within the liver’s biliary system, Thomann, Hemmer, Agrawal, and colleagues have unveiled an unpreceden...

From Gut Sensing to Feeding Suppression: Tuft–Enterochromaffin Cell Crosstalk Reveals a New Frontier in Gut–Brain Commun...

Constitutively active RAS prolongs Cdc42 signalling, while MAPK signalling is attenuated during fission yeast mating

by Emma J. Kelsall, Akatsuki Kimura, Ábel Vértesy, Kornelis R. Straatman, Mishal Tariq, Raquel Gadea, Chandni Parmar, Gabriele Schreiber, Shubhchintan Randhawa, Takashi Y. Ida, Cyr...

Macrophages Use Cell Volume Changes to Sense Danger and Amplify Inflammation

Macrophages use shifts in cell volume as a danger‑sensing cue that rewires gene expression, boosts type I interferon signaling, and intensifies inflammation. VRAC‑deficient cells r...

Tumour-driven lipid accumulation in oenocytes reflects systemic lipid alterations

by Chang Liu, Sofya Golenkina, Natasha Fahey, Priya Kumar, Louise Y. Cheng Cancer cachexia is a multifactorial syndrome characterized by systemic metabolic dysfunction, including...

Catecholaminergic Neurons Enhance Keloid Fibroblast Bone Growth

In a groundbreaking study set to transform our understanding of fibrotic skin disorders, researchers have uncovered a novel cellular interaction driving the abnormal bone-like tiss...

The Aged Gut Microbiome Generates Extracellular Vesicles that Harm Tissue Function

The gut microbiome is made of thousands of microbial species, many of which conduct activities necessary to health. Our tissues have evolved to at least somewhat rely upon the mole...

FAM129C Mutation Drives Achalasia via GABAA Immunity

In a groundbreaking study poised to reshape our understanding of achalasia, researchers have identified a critical genetic variant that triggers autoimmune responses leading to thi...