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journals.plos.org /1 week ago

<i>NLGN3</i> autism variants have distinct functional impact on synapses and sleep behavior in <i>Dros...

by Rebekah E. Townsley, Jonathan C. Andrews, Saurabh Srivastav, Sharayu V. Jangam, Shabab B. Hannan, Oguz Kanca, Paul C. Marcogliese, Shinya Yamamoto, Michael F. Wangler Neuroligi...

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rna-seqblog.com /1 month ago

Autism-risk mutations reveal two opposing patterns of brain gene activity

RNA sequencing reveals two opposing patterns of brain gene activity across genetically diverse autism-risk mouse models, with differences...

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scitechdaily.com /4 weeks ago

Autism Study Reveals Two Opposing Molecular Patterns in the Brain

An analysis of more than 1,000 gene activity profiles from mouse brains reveals shared molecular patterns that vary by sex and respond differently to experimental drugs. Autism spe...

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rna-seqblog.com /4 days ago

Advanced paternal age has sex-specific effects on fetal brain gene expression

RNA sequencing reveals sex-specific changes in embryonic brain gene expression associated with advanced paternal age, offering new insights into neurodevelopment and potential auti...

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genengnews.com /1 week ago

X-Chromosome Gene Linked to Increased Autism Diagnosis in Males

New research suggests that variants in the MECP2 gene on the X chromosome might help partly explain why autism is diagnosed about four times more often in males than it is in femal...

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medicalxpress.com /1 month ago

Placenta study identifies earliest signs of autism risk

How does autism develop? While genetics play a major role, researchers know that environmental factors during pregnancy also contribute to autism spectrum disorder.

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genengnews.com /3 weeks ago

Autism Target Discovered in Endothelial Cells in Genetic Deletion Mouse Model

Researchers reversed certain behavioral symptoms in a 16p11.2 deletion mouse model of autism spectrum disorder by activating the P2Y2 receptor in endothelial cells of brain blood v...

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huffingtonpost.co.uk /1 month ago

'Autism Is Genetic', Says Charity, In Response To 'False Claims' Over Causes

For the first time, a UK charity supporting autistic people has stated definitively that “autism is genetic”.The National Autistic Society (NAS) said the declaration comes in respo...

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medicalxpress.com /1 month ago

New findings shed light on rare newly identified TCF7L2-related neurodevelopmental disorder

Researchers have completed the largest study to date of TCF7L2-related neurodevelopmental disorder (TRND), a rare genetic condition caused by changes in the TCF7L2 gene, which play...

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fiercehealthcare.com /1 month ago

ARPA-H launches SPECTRA program, new autism research initiative

Researchers will create an end-to-end system to identify ASD risk factors, connect patients to appropriate interventions and accelerate clinical research for new therapies.

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sciencedaily.com /4 weeks ago

This “rare” autism-linked genetic disorder may be far more common than scientists thought

A major analysis suggests Phelan-McDermid syndrome, a genetic disorder closely linked to autism, may affect about 1 in 7,300 people and more than 45,000 Americans. Researchers warn...

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newatlas.com /1 month ago

Rare placenta-crossing infections triple risk of autism in children

Suspicions of a link between extremely rare congenital infections and the development of autism spectrum disorder (ASD) have been supported by a massive new study led by scientists...

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journals.plos.org /3 weeks ago

The prevalence of protein misfolding as a mechanism for hereditary deafness

by Rose A. Gogal, Genevieve M. Cox, Diana L. Kolbe, Amanda M. Odell, Chloe E. Ovel, Katherine I. McCormick, Brian Hong, Hela Azaiez, Thomas L. Casavant, Richard J. H. Smith, Terry...

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medicalxpress.com /1 week ago

Researchers identify role of newly discovered genetic variant in neurodevelopmental disorder

Researchers from Children's Hospital of Philadelphia (CHOP) have discovered the mechanisms of previously unknown changes in a gene that result in symptoms associated with a neurode...

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rna-seqblog.com /1 week ago

Overlooked DNA regions surrounding ‘microexons’ hold missing pieces of autism’s genetic puzzle

RNA sequencing and machine learning revealed more than 1,500 previously unidentified microexons and genetic variants affecting their splicing, providing new insights into autism-as...

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newatlas.com /1 month ago

Autism linked to early exposure to a common plastic additive

Di-(2-ethylhexyl) phthalate (DEHP) is commonly added to plastics to make them more flexible. It may also affect genes that play a critical role in brain development, promoting symp...

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disabilityscoop.com /1 month ago

Study May Point Way To New Autism Treatments

In what researchers are hailing as a landmark move, a new study is helping to explain how autism-linked genes rewire the brain potentially opening the door to treatments for the de...

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omanobserver.om /1 month ago

Study of brain proteins spurs optimism for autism treatments

Scientists have uncovered a wealth of clues about how genetic mutations lead to severe forms of autism, offering opportunities for testing drugs that could treat the condition, acc...

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