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aacr.org /1 month ago

Harmonizing Data Collection for Precision Oncology: AACR Project GENIE® Data Model

The AACR Project GENIE Data Model, recently released by the AACR GENIE consortium, is an open-access tool designed to help simplify data harmonization in precision oncology. Learn...

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academyhealth.org /2 weeks ago

AcademyHealth Releases Compendium of Cancer Biomarker Initiatives: A Central Repository for Cancer Biomarker Testing Res...

AcademyHealth Releases Compendium of Cancer Biomarker Initiatives: A Central Repository for Cancer Biomarker Testing Resources AcademyHealth’s Scaling Cancer Biomarker Test...

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aacr.org /3 weeks ago

Genomics Reveal New Layers of Pediatric Leukemia Biology

During the opening plenary session of the AACR Special Conference in Cancer Research: Bridging Discovery and Clinical Impact in Pediatric Cancer, the keynote presenter, Charles Mul...

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bioengineer.org /3 days ago

Rare EGFR mutation sharply raises lung cancer risk in large genetic study

An observational study of 3.3 million research participants found that inherited EGFR T790M was associated with 25-fold higher lung cancer risk overall and more than 60-fold risk a...

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journals.plos.org /1 week ago

Interpretable neural networks prioritize cancer driver genes from genome-wide dependency landscapes

by Qingyang Yin, Liang Chen Identifying cancer driver genes and their therapeutic impact remains a core challenge in computational cancer biology. We introduce xNNDriver and xAEDr...

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amrc.org.uk /1 month ago

Charities in action: Driving progress through genomics

Published: September 2026 In this report, we showcase how AMRC charities are advancing genomics and supporting its use to benefit patients - from research and infrastructure to po...

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genengnews.com /1 month ago

Genialis and Inventia Life Science Collaborate to Link Patient Biology with 3D Pancreatic Cancer Models

The collaboration pairs the Genialis Supermodel with Inventia Life Science’s RASTRUM 3D cell model platform to test therapeutic hypotheses in models that mirror the tumor biology o...

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genengnews.com /1 month ago

Aprea Expands Development of WEE1 Inhibitor After Seeing Early Clinical Activity Signs vs. Cancer

The Phase I dose escalation trial of ACESOT-1051 (NCT06260514) will accelerate its patient enrollment, with Aprea planning to more than triple its number of active clinical sites f...

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aacr.org /1 month ago

AACR and Kids Beating Cancer Launch New Grant to Advance Pediatric Leukemia Research

AACR and Kids Beating Cancer have announced a new grant to support pediatric leukemia research, with a particular focus on high-risk acute myeloid leukemia subtypes at the AACR Spe...

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journals.plos.org /2 weeks ago

Integrated multi-omics analysis reveals the molecular landscape and therapeutic strategies in Chinese cervical cancer pa...

by Tao Pan, Xucui Zhuang, Ya Zhang, Jiyu Guo, Si Li, Can Zhang, Lili Han, Fuxia Li, Yueying Gao, Jinyang Yu, Yongsheng Li, Chaoyang Sun Genomic or transcriptomic sequencing guides...

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journals.plos.org /2 days ago

Multi-omics analysis of high-grade serous ovarian cancers reveals heterogeneity and distinct immunological patterns base...

by Jing Qian, Rania Bassiouni, Yuxin Jin, Seeta Rajpara, Monica Neuman, Varun U. Khetan, Bodour Salhia, David W. Craig, Joseph W. Carlson, Lynda D. Roman, John D. Carpten High-gra...

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journals.plos.org /1 month ago

Identifying shared polygenic risk across cancers

by Jiaqi Hu, Maiyier Muheyati, Leqi Xu, Andrew DeWan, Hongyu Zhao Background Shared genetic susceptibility across cancers has been reported but is generally modest at the genome-wi...

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rna-seqblog.com /1 week ago

GARAGE improves rare cell detection in single-cell RNA sequencing analysis using AI

GARAGE uses artificial intelligence to generate realistic single-cell RNA sequencing data, improving rare cell representation, gene selection and cell clustering in complex biologi...

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journals.plos.org /1 month ago

Biomarker discovery and patient stratification in pancreatic cancer using incomplete multi-omics data

by Alejandra Paja-García, Rafael Romero-Becerra, Tero Aittokallio, Alberto López Pancreatic ductal adenocarcinoma (PDAC), with a 12% 5-year survival rate, is the most aggressive t...

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genengnews.com /1 day ago

Multiomic Study of MSS CRC Identifies Vulnerabilities Pointing to Therapeutic Possibilities

Researchers analyzed mulitomic and clinical data from 2000 colorectal cancer samples and used an AI tool, iPhenMap, to help identify cancer cell vulnerabilities and drug combinatio...

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journals.plos.org /1 week ago

Genome-Wide DNA methylation profiling of tissue-plasma pairs identifies Novel cfDNA biomarkers for the diagnosis of gast...

by Hailing Ou, Jinli Miao, Fusheng Ling, Jie Gao, Tingan Wang, Zhihua Ye, Chunbo Zhang, Mingwei Huang, Yuzhou Qin Screening for gastric cancer (GC) is critical for improving patie...

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genengnews.com /1 week ago

Designing the Ecosystem for CGT Success

This proceedings eBook, developed in partnership with GEN and Cincinnati Children’s Hospital Applied Gene and Cell Therapy Center, captures perspectives and lessons from The Cell S...

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genengnews.com /3 days ago

Bridging the Translational Gap in Pancreatic Cancer Through Biology-First Modeling

In this GEN webinar, our expert speaker Josh Wheeler, MD, PhD, will discuss a biology-first, interpretable AI approach to understand patient tumor states and next-generation precli...

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academyhealth.org /1 month ago

AcademyHealth Releases Strategic Roadmap for Advancing Cancer Biomarker Testing at Scale

AcademyHealth Releases Strategic Roadmap for Advancing Cancer Biomarker Testing at Scale For patients facing uncertainty or fear around a cancer diagnosis, cancer biomarker...

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bioengineer.org /1 day ago

Six-gene scoring system could help predict leukemia survival

Researchers in Barcelona report that a six-gene activity score, anchored by the Polycomb factor PHF19, divides acute myeloid leukaemia patients into groups with sharply different s...

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bioengineer.org /1 month ago

Functional genomics maps broad, convergent asciminib resistance mechanisms in BCR::ABL1

A sweeping genetic map of drug resistance in chronic myeloid leukemia has revealed that cancer cells can evade asciminib through mutations scattered across much more of the BCR::AB...

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qchron.com /4 days ago

Hengrui Pharma Previews ESMO Congress 2026: 64 Research Findings Highlight Continued Progress Across Innovative Pipeline...

64 research findings have been accepted, including three Proffered Paper presentations and three Rapid Oral presentations, spanning more than ten areas of oncology and supportive c...

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aacr.org /2 weeks ago

HER2-targeted Therapy for Salivary Gland Cancer

Salivary gland cancer is rare, and there are no standard treatments for advanced-stage disease. Recent research supports the use of HER2-targeted therapy for patients with metastat...

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genengnews.com /1 week ago

ADC Developmentfrom Concept to Clinic

This eBook brings insight on integrated end-to-end solutions for precision engineered therapeutics. The post ADC Developmentfrom Concept to Clinic appeared first on GEN - Genetic E...

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