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aacr.org /1 week ago

Harmonizing Data Collection for Precision Oncology: AACR Project GENIE® Data Model

The AACR Project GENIE Data Model, recently released by the AACR GENIE consortium, is an open-access tool designed to help simplify data harmonization in precision oncology. Learn...

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aacr.org /1 month ago

The AACR Rare Cancers Initiative: Uniting Researchers, Undoing Barriers, and Unleashing Progress

At the recent AACR Special Conference on Breaking Barriers in the Fight Against Rare Cancers, AACR Immediate Past President Lillian L. Siu, MD, FAACR, announced the AACR Rare Cance...

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bioengineer.org /3 weeks ago

Global Cancer Genomics Enabled by Centralized Processing of Frozen Tumor Tissues

Cancer researchers have unveiled a standardized pathology and molecular workflow designed to solve one of the most difficult problems in international genomics: turning frozen tumo...

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genengnews.com /1 month ago

Patient-Derived Tumor Organoids Show Promise for Personalizing Cancer Treatment

Researchers developed a 220-sample pan-cancer patient-derived organoid platform that faithfully mirrors tumors, identifies new treatment opportunities, and advances precision oncol...

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genengnews.com /1 month ago

Novel Epigenetic Therapy Targets Treatment-Resistant and TP53-Mutant AML

The results of a preclinical study across multiple models of acute myeloid leukemia found that the investigational hypomethylating agent, NTX-301 remained effective in treatment-re...

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rna-seqblog.com /3 weeks ago

Novel AI model trained on RNA-Seq data accurately detects key gene mutations and predicts biomarkers across 32 cancer ty...

RNA sequencing and pathology imaging data helped train an AI model to predict TP53 mutations, gene expression, cancer type, and clinical outcomes across solid tumors...

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aacr.org /1 month ago

Editors’ Picks, July 2026: AI-powered Pancreatic Proteomics, Sex-based Immune Differences, and More

In July, the editors from AACR's 10 peer-reviewed journals highlighted research on AI-driven molecular mapping of pancreatic cancer evolution, sex differences in immune responses,...

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genengnews.com /1 week ago

Aprea Expands Development of WEE1 Inhibitor After Seeing Early Clinical Activity Signs vs. Cancer

The Phase I dose escalation trial of ACESOT-1051 (NCT06260514) will accelerate its patient enrollment, with Aprea planning to more than triple its number of active clinical sites f...

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journals.plos.org /1 month ago

ALFAssay: A feed‑forward neural network for quantitative fragmentomics‑based ctDNA profiling in breast cancer

by Alexandra Stanciu, Andrea Gombos, Elisa Agostinetto, Delphine Vincent, Laurence Buisseret, Andreas Papagiannis, Francoise Rothe, Nicola Occelli, Christos Sotiriou, David Venet,...

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genengnews.com /1 month ago

Colorectal Cancer Targeted with Mass-Produced iPSC-Derived Allogeneic T Cells

Researchers generated off-the-shelf, mass-producible iPSC-derived allogeneic γδT cells that in a small preclinical study suppressed tumor growth in mouse colorectal cancer xenograf...

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academyhealth.org /6 days ago

AcademyHealth Releases Strategic Roadmap for Advancing Cancer Biomarker Testing at Scale

AcademyHealth Releases Strategic Roadmap for Advancing Cancer Biomarker Testing at Scale For patients facing uncertainty or fear around a cancer diagnosis, cancer biomarker...

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aacr.org /1 month ago

From the Bench, AACR D3 2026: Emerging Therapeutic Strategies to Inhibit KRAS, Enhance ADCs, and Tackle Resistance

The AACR D3 edition of “From the Bench” highlights cutting-edge approaches from the meeting that could shape the next generation of cancer treatments. We spoke with Andrea Wang-Gil...

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journals.plos.org /4 weeks ago

An alignment-free strategy for circulating tumor DNA detection and tumor fraction estimation from whole-genome sequencin...

by Carmen Oroperv, Amanda Frydendahl, Tenna Vesterman Henriksen, Giovanni Santacatterina, Alice Antonello, Nicola Calonaci, Mads Heilskov Rasmussen, Giulio Caravagna, Claus Lindbje...

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journals.plos.org /1 month ago

In silico clinical trials of BiTE expression by oncolytic viruses reveal the impact of patient heterogeneity on dosage p...

by Adrianne L. Jenner, Robyn P. Araujo, Noa L. Levi, Guy Ungerechts, Christine E. Engeland, Johannes P. W. Heidbuechel Immunotherapies have become a transformative therapeutic str...

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bioengineer.org /1 week ago

Functional genomics maps broad, convergent asciminib resistance mechanisms in BCR::ABL1

A sweeping genetic map of drug resistance in chronic myeloid leukemia has revealed that cancer cells can evade asciminib through mutations scattered across much more of the BCR::AB...

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aacr.org /4 weeks ago

AACR in the News: Cancer Disparities Progress Report and OMB Statement

A variety of national and local news outlets have highlighted AACR initiatives and experts in recent weeks. Learn about the news stories covering the findings from the AACR Cancer...

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letlifehappen.com /1 week ago

Genome analysis uncovers candidate genes for hereditary breast and ovarian cancer

By: Inka Burow, Hannover Medical School From: medicalxpress.com Breast cancer is the most common form of cancer among women in Germany: Around 1 in 8 women will develop it during t...

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aacr.org /1 month ago

Inaugural AACR D3 Opens With Insights From Leaders Across Drug Discovery and Development

During the opening session of the AACR Conference on Drug Discovery and Development, the conference cochairs—Patricia M. LoRusso, DO, PhD (hc), FAACR; Keith T. Flaherty MD, FAACR;...

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aacr.org /1 month ago

AACR D3 Offered a Peek Into the Cancer Drug Pipeline, Innovative AI Tools, and More

We highlight some of the many innovations showcased at the inaugural AACR Drug Discovery and Development (AACR D3) conference, including investigational KRAS degraders, approaches...

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bioengineer.org /3 weeks ago

CTPS1 Drives Lung Adenocarcinoma Progression, Revealing a Targetable Vulnerability

A metabolic enzyme best known for helping cells build the genetic material needed for growth has emerged as a potential weakness in lung adenocarcinoma, the most common major subty...

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bioengineer.org /1 month ago

HKU Researchers Develop ClairS for Accurate Mutation Detection Across Cancers

A new artificial-intelligence system developed by researchers at The University of Hong Kong could make it significantly easier to identify cancer-causing mutations hidden in the m...

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rna-seqblog.com /1 month ago

RNA-based testing uncovers extraordinary diversity in mutations driving lung cancer

RNA sequencing improved detection of clinically important MET exon 14 skipping events, helping identify lung cancer patients who may benefit from targeted therapies...

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medicalxpress.com /3 weeks ago

Genomic newborn screening could identify some children at risk for early cancers

A large population-based study led by researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Mass General Brigham suggests that genetic testing added to...

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aacr.org /1 week ago

Breaking News: Daraxonrasib Approved for Pancreatic Cancer

Today, the U.S. Food and Drug Administration approved daraxonrasib (Rasonque), a groundbreaking new drug for pancreatic cancer that targets the RAS family of proteins. Catch up on...

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