Search results for #Amyloidosis

EM@3AM: Amyloidosis

The EM@3AM series returns with amyloidosis. The post EM@3AM: Amyloidosis appeared first on emDocs.

Amyloid light-chain amyloidosis presenting as lambda-restricted tubular amyloid casts

A 54-year-old man with a history of inflammatory bowel disease and hypertension who was admitted for transient ischemic attack was found to have congestive heart failure, anemia, a...

Amyloid in Primary Hip Arthroplasty Specimens: An Opportunity for Early Detection of Amyloidosis?

Recent advances in pharmacologic therapies to treat amyloidosis demand renewed focus on early identification of patients who will benefit from these therapies. Incidental detection...

Have you heard of ATTR-Cardiac Amyloidosis (ATTR-CM)?

+ Infographic textWhat is ATTR-CM? ATTR-cardiac amyloidosis is a disease of the heart muscle. It is caused by a buildup of abnormal proteins (amyloid) in the walls of the heart.  A...

Data on the Effective Long Term Treatment of Transthyretin Amyloidosis

Transthyretin is one of a small number of proteins that can misfold and aggregate to cause pathology in tissues, primarily the cardiovascular system, but other organs as well once...

¿Has escuchado hablar de la amiloidosis cardíaca por transtiretina (ATTR-CM)?

English+ Infographic text¿Qué es la ATTR-CM? La amiloidosis cardíaca por transtiretina es una enfermedad del músculo cardiaco. Ocurre por una acumulación de proteínas anormales (am...

PM20D1 Creates N-oleoyl-Leucine to Improve Clearance of Amyloid-β Aggregates by Microglia

Researchers here note a mechanism that encourages the innate immune cells known as microglia to better clear amyloid-β in the aging brain. The protein PM20D1 acts in the formation...

Polyneuropathy in p.V142I hereditary transthyretin amyloidosis: Diagnostic challenges and clinical considerations

We appreciate Dr. Christian Messina's comments on our recent paper reviewing the “prevalence and attribution of polyneuropathy in p.V142I (V122I) hereditary transthyretin amyloidos...

From prevalence to precision: Interpreting neuropathy in transthyretin amyloidosis

We read with great interest the article by Dvorak JE et al., which addresses the important issue of polyneuropathy (PN) in individuals carrying the p.V142I transthyretin variant [1...

Prevalence and attribution of polyneuropathy in p.V142I (V122I) hereditary transthyretin amyloidosis

The p.V142I (V122I) transthyretin variant (TTRv) is the most common amyloidogenic TTRv in the United States, particularly among Black people. While p.V142I ATTRv is primarily assoc...

Accumulated Consequences: Severe Intestinal Failure in Familial Mediterranean Fever

The Case | Febrile pancytopenia with mixed cryoglobulinemia and glomerulonephritis in a traveler

A 70-year-old man, originally from Cape Verde, residing in France since 2020 with frequent return visits, presented with fatigue, unintentional weight loss (15 kg over the past yea...

Protein misfolding enteropathy predicts and prognosticates neurodegenerative disease years before symptom onset

Neurodegenerative disorders are characterized by progressive, irreversible neuronal loss that often advances silently for years before symptoms appear. Disease-modifying therapies...

This Simple Amino Acid Supplement Greatly Reduces Alzheimer’s Damage

May 04, 2026 | Source: Science Daily | by Kindai University Alzheimer's disease (AD) is a progressive brain disorder and a leading cause of dementia worldwide. Despite years of re...

Anti-glomerular basement membrane disease: variant forms and underlying mechanisms

Anti-glomerular basement membrane (GBM) disease is the most severe form of autoimmune glomerulonephritis following assaults on kidney and alveolar basement membranes by pathogenic...

Therapeutic Efficacy and Antigenicity of a Novel PEGylated IgA Protease in Preclinical Models of IgA Nephropathy

IgA nephropathy is the most common primary glomerulonephritis worldwide, characterized by IgA deposition and a high risk of progression to kidney failure. While emerging therapies...

What’s the deal with Alzheimer’s disease and amyloid?

For decades, scientists have concentrated on what now looks to be a blind alley.

Podocyte zebra bodies in LMX1B-associated nephropathy: a Fabry mimic

A 32-year-old male patient with a recent history of cerebral infarction was referred for abnormal urinalysis. He had 4.7 g/24 h proteinuria, hypoalbuminemia (31.8 g/l), microscopic...

Reviewing the Inability of Anti-Amyloid Immunotherapies to Affect Alzheimer's Disease

In the context of Alzheimer's disease, the data for anti-amyloid immunotherapies, the most recent of which do effectively clear the aggregation of amyloid-β in the brain, is not co...

A protective gene sent to the liver cleared amyloid from mouse brains, sparking hope for an Alzheimer’s gene therapy

The calling card of Alzheimer’s disease is a buildup of misfolded amyloid protein in the brain, but many medicines struggle to penetrate the barrier protecting the mind from outsid...

Pegcetacoplan Prophylaxis for Recurrent C3 Glomerulopathy with Multifactorial Genetic Background

A 9-month-old female infant with no family history of kidney disease was admitted in 2014 for macroscopic haematuria. Laboratory tests showed normal renal function (eGFR sec. Schwa...

Amylyx (AMLX) Q1 2026 Earnings Transcript

Image source: The Motley Fool. DATEThursday, May 7, 2026 at 8 a.m. ETCALL PARTICIPANTSCo-Chief Executive Officer — Justin KleeCo-Chief Executive Officer — Joshua CohenChief Commer...

Bloodlines Series: CAR T-cell Therapy Shows Promise for Smoldering Myeloma

An immunotherapy typically used in advanced stages of multiple myeloma may be effective against an early form of the disease known as smoldering myeloma—offering a potential new op...

Angioinvasive Renal Aspergillosis with Calcium Oxalate Deposits

A 30-year-old immunocompetent male farmer, treated for one month with multiple oral and intravenous antibiotics for urinary tract infection elsewhere presented to the emergency dep...