Search results for Oncogenic Pathways

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genengnews.com /1 week ago

Oncogenic Signaling Shaped by a Golgi Trafficking Protein Pair

A new study shows that the Golgi proteins GOLPH3 and MYO18A control delivery of RTKs to the cell surface, defining signaling strength and revealing a potential vulnerability in RTK...

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bioengineer.org /2 weeks ago

Unraveling Raf-MEK-ERK Pathway in Prostate Cancer

The landscape of cancer therapy has been profoundly revolutionized by clinical interventions targeting the MAPK (Mitogen-Activated Protein Kinase) pathway, a critical signaling cas...

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rna-seqblog.com /1 month ago

Researchers identify cellular pathways that drive precancerous lesions to form pancreatic tumors

RNA sequencing identifies metabolic pathways that regulate pancreatic precancerous lesions, revealing how NADPH-producing enzymes limit disease progression and offering potential t...

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gastrojournal.org /6 days ago

Targeting oncomucin-driven immunosuppression improves the efficacy of K-rasG12D inhibition in pancreatic cancer

Oncogenic de novo mucins (oncoMUCs; MUC4, MUC16, and MUC5AC) are progressively upregulated in pancreatic ductal adenocarcinoma (PDA). While their individual cell-intrinsic roles ha...

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bioengineer.org /1 month ago

Targeting Master Regulators: A Unified Cancer Therapy

In a transformative leap forward for cancer therapy, a groundbreaking study published in Cell Death Discovery unveils a unified therapeutic theory that holds the potential to revol...

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journals.plos.org /1 month ago

Constitutively active RAS prolongs Cdc42 signalling, while MAPK signalling is attenuated during fission yeast mating

by Emma J. Kelsall, Akatsuki Kimura, Ábel Vértesy, Kornelis R. Straatman, Mishal Tariq, Raquel Gadea, Chandni Parmar, Gabriele Schreiber, Shubhchintan Randhawa, Takashi Y. Ida, Cyr...

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