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bioengineer.org /1 week ago

How a Cellular Stress Switch Helps Tumours Hide From the Immune System

A new review reveals how the unfolded protein response, a cellular stress-signalling network, helps tumours evade immune detection and could be targeted to boost cancer immunothera...

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bioengineer.org /2 weeks ago

Hidden armies inside glioblastoma: exhausted T cells hint at new immunotherapy routes

Single-cell analysis of 56 glioblastoma tumors reveals that T-cell-rich cases harbor clonally expanded, LAG3-high CD8 T cells that may be tumor-reactive, opening new avenues for im...

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bioengineer.org /4 weeks ago

AI-Guided Modeling Uncovers Hidden Switches That Could Heat Up Cold Pancreatic Tumors

Pancreatic ductal adenocarcinoma remains one of the deadliest cancers in the world, and one of the hardest to treat with immunotherapy. The reason lies in its notorious reputation...

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nanowerk.com /1 week ago

How nanomedicine could turn immune-resistant tumors against themselves

Polymer-based nanomedicines could reshape the tumor microenvironment, helping immune cells attack resistant cancers and potentially improve immunotherapy.

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webwire.com /1 month ago

How to Teach T Cells to Track Cancer Like a Hound Dog

The immune system is full of T cells that could hunt down and destroy tumors, if they were primed. Now, a UC San Francisco team has invented a way to do this by combining immune ce...

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newatlas.com /1 week ago

An overlooked immune cell offers a way to treat deadliest lung cancers

An overlooked population of immune cells could offer a new way to attack one of the deadliest forms of lung cancer.Continue ReadingCatego...

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bioengineer.org /4 weeks ago

Staphylococcal Protein Reprograms Liver Tumor Macrophages to Boost Immunotherapy

One of the most stubborn obstacles in cancer immunotherapy is not the tumor cell itself but the cellular entourage that surrounds it. In hepatocellular carcinoma, the most common f...

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fightaging.org /3 weeks ago

A Unified Cause for Loss of Type 1 Dendritic Cell Function in Aging, Cancer, and Chronic Infection

Type 1 conventional dendritic cells are a subclass of dendritic cell known to be an important component of the immune response to pathogens and cancerous cells, particularly focuse...

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nanowerk.com /1 month ago

Smart nanoparticles reprogram tumor immune cells to boost cancer attack

Targeted lipid nanoparticles deliver mRNA to tumor-associated macrophages, reprogramming the immune environment and strengthening anti-cancer T-cell activity in mice.

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bioengineer.org /2 weeks ago

Stem Cell Feeder Platforms Boost Natural Killer Cells for Cancer Immunotherapy

Researchers have developed engineered feeder cells derived from induced pluripotent stem cells that prolong the survival and boost the killing power of natural killer cells, offeri...

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bioengineer.org /1 month ago

Scientists Advance Precision Cancer Immunotherapy

Cancer immunotherapy is entering a more controlled and technically sophisticated phase, according to a wide-ranging collection of studies and reviews that outline how researchers a...

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fightaging.org /1 month ago

Lingering Senescent Cells in Aged Tissues Use PD-L2 to Evade Destruction by Immune Cells

PD-L1 and PD-L2 are components of immune checkpoints, widely expressed in tissues throughout the body. They act by binding to the PD-1 receptor on immune cells to suppress immune a...

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bioengineer.org /1 month ago

Dendritic cell SHP1 limits memory CD8 T cell development through TCF-1/Wnt signaling

In a discovery that could reshape how scientists think about the durability of cancer immunity, a team of researchers in China has identified an unexpected molecular brake inside d...

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bioengineer.org /1 month ago

ID2 directs cDC1 development by blocking E proteins at versatile Zeb2 enhancer

A new study has uncovered how the immune system locks developing cells into the type 1 classical dendritic cell, or cDC1, lineage—an immune cell population that plays a central rol...

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prweb.com /1 month ago

Chemo-Resistant Pancreatic Tumor Liquefies and Drains Several Months after Receiving Proprietary Intratumoral EpCAM/CD3...

Peer-reviewed case report documents 90% volume reduction together with extensive necrosis — achieved without surgery or full-dose chemotherapy after gemcitabine failed SAN DIEGO, S...

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bioengineer.org /2 weeks ago

Immune Cells Cluster Around Blood Vessels to Predict Lung Cancer Immunotherapy Success

Immunotherapy has transformed the treatment landscape for non-small cell lung cancer, the most common form of lung malignancy worldwide, yet a stubborn problem persists: only a sub...

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bioengineer.org /1 month ago

Nanoparticles Could Help Radiation Turn Cancer Immunity Into Durable Treatment

Radiotherapy may do more than destroy cancer cells at the site of treatment: it can also alert the immune system to the tumor. Yet that alarm is often too faint, too brief, or too...

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fightaging.org /2 days ago

Creation of Chimeric Antigen Receptor Natural Killer Cells in Situ via Messenger RNA Therapy

Messenger RNA (mRNA) can be delivered into tissues and cells by encapsulating it into lipid nanoparticles (LNPs), and then injecting the nanoparticles. A target cell engulfs a LNP,...

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fightaging.org /1 month ago

Dendritic Cell Antigen Presentation Enables T Cells to Enter the Brain and Contribute to Tau Pathology

The immune systems of the body and brain are distinct and separate, or at least largely separate, influencing one another via signaling. The blood-brain barrier keeps the vast majo...

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letlifehappen.com /1 month ago

Triple-negative breast cancer: Methylglyoxal at the heart of immune evasion

From: Erurekalert.org A study reveals how methylglyoxal stress – a consequence of cancer cell metabolism – promotes immunosuppression and the formation of metastases, and may contr...

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medicalxpress.com /2 weeks ago

Making pediatric cancer more 'visible' boosts immunotherapy response

High-risk neuroblastoma is one of the most aggressive forms of solid tumors affecting children, originating in the nervous system. While a newer class of targeted immunotherapy dru...

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scitechdaily.com /1 month ago

Could This Cellular “Cleanup Crew” Hold New Clues to Chronic Inflammation?

The discovery could offer new clues about chronic inflammatory conditions. Cells in tissues such as the skin, gut, and airways regularly die and need to be removed. Their neighbors...

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bioengineer.org /1 month ago

Sugar Signature Reveals Which Tumor-Fighting T Cells Are Most Vulnerable

Inside a growing tumor, a silent biochemical war is fought not just between cancer cells and immune cells, but across the very surfaces of those immune cells themselves. A team of...

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genengnews.com /1 month ago

Chronic Interferon Exposure Linked to Immunosuppression in Cancer

A preclinical study uncovered a novel pathway that links chronic IFN-II exposure to mitochondrial dysfunction and ultimately immunosuppression in cancer, creating foundational insi...

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