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PD-L1 found on the surface of cells is a well known immune checkpoint protein. When it binds to the receptor PD-1 found on the surface of T cells and B cells, it acts to suppress i...
PD-L1 and PD-L2 are components of immune checkpoints, widely expressed in tissues throughout the body. They act by binding to the PD-1 receptor on immune cells to suppress immune a...
Gastric cancer remains one of the world’s deadliest malignancies, ranking fifth among the most commonly diagnosed cancers and accounting for roughly 7.7 percent of all cancer-relat...
In a discovery that could reshape how scientists think about the durability of cancer immunity, a team of researchers in China has identified an unexpected molecular brake inside d...
A new review reveals how the unfolded protein response, a cellular stress-signalling network, helps tumours evade immune detection and could be targeted to boost cancer immunothera...
One of the most stubborn obstacles in cancer immunotherapy is not the tumor cell itself but the cellular entourage that surrounds it. In hepatocellular carcinoma, the most common f...
Single-cell analysis of 56 glioblastoma tumors reveals that T-cell-rich cases harbor clonally expanded, LAG3-high CD8 T cells that may be tumor-reactive, opening new avenues for im...
Blocking an antioxidant protein that tumors use to suppress immune attacks improved cancer immunotherapy responses in mice. Cancer cells can release antioxidants that interfere wit...
Most people have heard of cancer immunotherapy by now. These treatments help a patient’s own immune system recognize and attack cancer. The best-known examples are immune checkpoin...
by Chenghang Li, Yuhong Zhang, Xue Liu, Yipu Qu, Xiulan Lai, Jinzhi Lei Continuous antigen exposure drives T cells into a progressive state of dysfunction known as exhaustion, ena...
Immunotherapy has transformed the treatment landscape for non-small cell lung cancer, the most common form of lung malignancy worldwide, yet a stubborn problem persists: only a sub...
Solstice Oncology is advancing a medicine from China’s Harbour BioMed that it believes is able to address the weaknesses of drugs aimed at CTLA-4, a popular but tricky cancer immun...
A carefully designed clinical trial that set out to supercharge the immune system’s attack on advanced melanoma has delivered a sobering but scientifically valuable verdict. Resear...
Researchers at Purdue University have developed a small-molecule compound that could open a new route toward cancer immunotherapy by targeting a protein that normally restrains imm...
Pancreatic ductal adenocarcinoma remains one of the deadliest cancers in the world, and one of the hardest to treat with immunotherapy. The reason lies in its notorious reputation...
Aging may be partly fueled by immune cells losing their ability to clear away damaged, inflammation-promoting cells. Blocking a single receptor restored that cleanup process in mic...
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