Search results for Glomerular Diseases

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kidney-international.org /1 week ago

Anti-glomerular basement membrane disease: variant forms and underlying mechanisms

Anti-glomerular basement membrane (GBM) disease is the most severe form of autoimmune glomerulonephritis following assaults on kidney and alveolar basement membranes by pathogenic...

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kidney-international.org /4 weeks ago

Podocyte zebra bodies in LMX1B-associated nephropathy: a Fabry mimic

A 32-year-old male patient with a recent history of cerebral infarction was referred for abnormal urinalysis. He had 4.7 g/24 h proteinuria, hypoalbuminemia (31.8 g/l), microscopic...

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journals.plos.org /1 month ago

Systematic prioritization of potential therapeutic targets for glomerulonephritis using multi-omics Mendelian randomizat...

by Guoqiang Li, Fu Jianhan, Jiashu Gu, Yinhuai Wang, Jiachen Liu, Dong Yang, Dianjie Zeng, Pengcheng Zhao Glomerulonephritis (GN) is an immune-mediated kidney disorder that causes...

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kidney-international.org /1 month ago

Pegcetacoplan Prophylaxis for Recurrent C3 Glomerulopathy with Multifactorial Genetic Background

A 9-month-old female infant with no family history of kidney disease was admitted in 2014 for macroscopic haematuria. Laboratory tests showed normal renal function (eGFR sec. Schwa...

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kidney-international.org /2 weeks ago

Tubulointerstitial Diseases: An Updated Framework for Diverse and Emerging Entities

Tubulointerstitial diseases represent a heterogeneous group of kidney diseases with diverse causes and overlapping histopathologic and immunophenotypic patterns. Unlike glomerular...

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kidney-international.org /1 month ago

A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease

The maintenance of a healthy epithelial-endothelial juxtaposition requires crosstalk within glomerular cellular niches. Here, we sought to understand the spatially anchored regulat...

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kidney-international.org /1 week ago

Role of the Post-translational ISGylation of Interferon Regulatory Factor 9 in Diabetes-Induced Podocyte Injury

Diabetic kidney disease (DKD) is the most common cause of kidney failure, with podocyte injury being a key event in its progression. Here, by performing single-cell regulatory netw...

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kidney-international.org /4 weeks ago

Communication leading to injury: podocyte-derived fibrillin-1 induces mesangial cell activation and proliferation throug...

The mechanism by which podocyte injury induces mesangial activation, a pathologic hallmark of glomerulosclerosis, is poorly understood. In this issue of Kidney International, He et...

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journals.plos.org

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kidney-international.org

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