GP-DHT uses single-cell RNA sequencing to map gene regulatory networks
Single-cell RNA sequencing combined with GP-DHT helps predict transcription factor and target gene relationships, providing a...
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Single-cell RNA sequencing combined with GP-DHT helps predict transcription factor and target gene relationships, providing a...
by Carolyn Sangokoya, Isabella R. Rosso, Rana Ghandehari-Alavijeh, Robert Blelloch Post-transcriptional control by RNA binding proteins (RBPs) and microRNAs play central roles in...
by Yann Maugé, Elias Ventre A key challenge in inferring gene regulatory networks (GRNs) governing cellular processes such as differentiation and reprogramming from experimental d...
by Marine Fontaine, M. Joaquina Delás, Meritxell Sáez, Rory J. Maizels, Elizabeth Finnie, James Briscoe, David A. Rand Building a mechanistic understanding of cell fate decisions...
by Kazunori Ando, Sushant Bangru, John Welsby, John D. Thompson, Kenneth D. Poss Regeneration programs enable animals to restore damaged or lost tissues, and the range of stimuli...
A comparative study in two beetle species links evolving regulatory DNA and condition-specific chromatin changes to horn diversification, with functional evidence for two BMP-pathw...
by Phillip L. Davidson, Isabel G. Manley, Armin P. Moczek Condition-responsive growth is a common feature of multicellular development, during which organisms integrate genetic an...
by Rafael Riudavets Puig, Denise G. O’Mahony, Ina Skaara Brorson, Ksenia Sokolova, Vessela N. Kristensen, Anthony Mathelier Transcription is regulated through the sequence-specifi...
by Tianyu Wu, Marie-Christin Spindler, Abner T. Apsley, Emmy Earnest, Zane R. Thornburg, Julia Mahamid, Zaida Luthey-Schulten Eukaryotic cells are spatially organized into functio...
by Tal Gordon, Tom Levy, Chester Jiamu Yu, Benyamin Rosental, Lauren Lubeck, Lucia Manni, Irving L. Weissman, Ayelet Voskoboynik Many tissues harbor quiescent stem cells that acti...
A new computational framework that identifies minimal temporary gene-control interventions to steer cells toward desired states while preserving cellular plasticity.
by Qingyang Yin, Liang Chen Identifying cancer driver genes and their therapeutic impact remains a core challenge in computational cancer biology. We introduce xNNDriver and xAEDr...
A Master Switch in Salmonella May Link Sticky Biofilms to Bacterial “Social” Signals A gene regulator best known for helping Salmonella build its tough, adhesive biofilms may also...
Researchers show that long-range chromatin loops help control tissue regeneration, revealing a direct role for 3D genome organization in regenerative processes.
Single-cell RNA sequencing reveals how lymphatic-derived Reelin influences epicardial cells, fibroblasts and growth signaling involved in heart development and potentially cardiac...
by Vedant D. Jain, Andrew M. Johannesen, Felipe L. Teixeira, Erik A. Lundquist Hox genes have been broadly implicated in nervous system development, but the molecular and genetic...
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