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RNA sequencing captures both coding and noncoding RNAs at single-cell resolution, revealing complex regulatory programs and cellular identities across development and disease...
Researchers show that gene syntax reshapes DNA supercoiling, amplifying or suppressing neighboring genes. The work uncovers a design rule that could improve the precision and behav...
Long-distance gene control first emerged around 650 to 700 million years ago, significantly earlier than scientists had previously believed. Life depends on timing. Every cell must...
by Maik Mendler, Kristin Krause, Simone Zündorf, Prathamesh Sannak, Petra Tänzler, Sara Stolze, Hirofumi Nakagami, Franziska Turck Epigenetic regulators shape chromatin landscapes...
Scientists used a bacterial system called retron to turn DNA into a programmable tool inside living cells, enabling gene regulation and disease detection.
In a groundbreaking study poised to redefine our understanding of gene regulation, researchers have harnessed the power of multiomics and advanced deep learning to probe the intric...
By tracking gene regulation in single cells over time, PerturbFate can systematically map how diverse disease-associated genetic variations reshape cells to understand complex dise...
In the intricate landscape of genetic regulation, the study of RNA-binding proteins is unraveling new dimensions of molecular control mechanisms pivotal for development and disease...
by Clelia Corridori, Merrit Romeike, Giorgio Nicoletti, Christa Buecker, Samir Suweis, Sandro Azaele, Graziano Martello Physiological and pathological processes are governed by ne...
RNA sequencing reveals how Sox9 dynamically regulates gene expression during cartilage development, highlighting distinct cell populations and shifting genetic programs...
RNA sequencing with regRNA Capture-seq identified thousands of regulatory RNAs and enabled new strategies to increase expression of disease-related genes using ASOs...
While development is often described as a series of static snapshots of cell states, RegVelo models how these fate decisions are encoded in gene regulatory networks over time and s...
by Elif Sarinay Cenik How animals allocate resources between growth, maintenance, and reproduction is a fundamental question. In this issue of PLOS Biology, Pradhan and colleagues...
by Haik V. Varderesian, Juliet N. Utaegbulam, Hannah E. Brown, Beverly Ramirez, Melina Velcani, Sean P. Ryder During fertilization, haploid gametes combine to form a zygote. The m...
RNA sequencing combined with perturbation data enables PSGRN to improve gene regulatory network inference, enhancing accuracy in identifying gene interactions across single-cell...
by Debomita Chakraborty, Raghunathan Rengaswamy, Karthik Raman A unique balance of seemingly contradictory properties like robustness and plasticity, or evolvability and functiona...
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