Search results for Fusion Oncogenes

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rna-seqblog.com /2 weeks ago

FUSILLI -long-read fusion detection

RNA sequencing with FUSILLI improves detection of leukemia fusion oncogenes, supporting more accurate molecular diagnosis and subtyping in pediatric B-cell acute lymphoblastic leuk...

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genengnews.com /1 week ago

Oncogenic Signaling Shaped by a Golgi Trafficking Protein Pair

A new study shows that the Golgi proteins GOLPH3 and MYO18A control delivery of RTKs to the cell surface, defining signaling strength and revealing a potential vulnerability in RTK...

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bioengineer.org /2 weeks ago

Cancer-Linked Protein Plays Key Role in Tumor DNA Repair

A groundbreaking study from Oregon Health & Science University (OHSU) unveils a previously unrecognized role of the notorious cancer-driving protein MYC. Long established as a...

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medicalxpress.com /1 month ago

An enhancer within tumors provides a potential target for 'undruggable' MYC in pediatric medulloblastoma

Efforts to develop effective therapies for MYC-amplified Group 3 medulloblastoma (G3-MB) are hindered by an incomplete understanding of how MYC expression is controlled in these tu...

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scitechdaily.com /3 weeks ago

Breakthrough Technology Reveals New Treatment Targets for Cancer

A single-cell platform reveals that many genetic mutations converge on shared cellular programs, pointing to simpler, more unified treatment strategies. What if hundreds of differe...

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journals.plos.org /1 month ago

Constitutively active RAS prolongs Cdc42 signalling, while MAPK signalling is attenuated during fission yeast mating

by Emma J. Kelsall, Akatsuki Kimura, Ábel Vértesy, Kornelis R. Straatman, Mishal Tariq, Raquel Gadea, Chandni Parmar, Gabriele Schreiber, Shubhchintan Randhawa, Takashi Y. Ida, Cyr...

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rna-seqblog.com /1 month ago

IMA histology should trigger RNA sequencing in NSCLC – here’s why

RNA sequencing enables detection of NRG1 fusions in invasive mucinous adenocarcinoma, ensuring accurate molecular profiling and identification of actionable targets often missed by...

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bioengineer.org /3 weeks ago

ALK Mutation Identified as a Predictive Biomarker for Pan-Cancer Immunotherapy

A groundbreaking study published in Genes & Diseases has unveiled the crucial role of anaplastic lymphoma kinase (ALK) mutations across multiple cancer types in predicting robu...

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sciencedaily.com /2 weeks ago

Scientists discover why some cancers survive chemotherapy

Scientists have uncovered a surprising new trick used by one of cancer’s most notorious proteins. MYC, already infamous for fueling runaway tumor growth, also appears to help cance...

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fiercebiotech.com /1 month ago

Drug combo treats multiple cancers with ‘paradox’ mutation in mice

A detailed look at a mysterious mutation present in many different cancer types has revealed new drug targets that, when hit with a combo of well-known compounds, led to tumor cell...

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