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Latest updates for Differential Gene Expression

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journals.plos.org /1 month ago

Bacterial chromosomal gene positioning is likely shaped by selection on both mean and growth-dependent expression

by Ruiqi Yuan, Jianzhi Zhang In bacteria with circular chromosomes, genes near the replication origin (oriC) are replicated earlier and consequently attain higher copy numbers tha...

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bioengineer.org /2 days ago

Willow HMG genes show sex-associated expression across three flower types

RNA sequencing and expression assays in the ‘J795’ willow identified 19 HMG genes, including the male-flower-highest HMG18, as candidates for research on sex differentiation.

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journals.plos.org /1 month ago

Developmental and tissue expression breadth define distinct but overlapping classes of housekeeping genes

by Alicia Lou, Juan F. Poyatos, Monica Chagoyen Housekeeping genes are commonly defined as broadly expressed genes that support essential cellular function. However, their identif...

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rna-seqblog.com /1 month ago

Autism-risk mutations reveal two opposing patterns of brain gene activity

RNA sequencing reveals two opposing patterns of brain gene activity across genetically diverse autism-risk mouse models, with differences...

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rna-seqblog.com /2 weeks ago

GP-DHT uses single-cell RNA sequencing to map gene regulatory networks

Single-cell RNA sequencing combined with GP-DHT helps predict transcription factor and target gene relationships, providing a...

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rna-seqblog.com /1 month ago

A real-data approach to evaluating RNA transcript analysis methods

RNA sequencing data provide a real-world framework for comparing differential transcript usage methods across bulk, single-cell, spatial, long-read, and short-read transcriptomics....

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rna-seqblog.com /1 month ago

scLS – a computationally efficient differentially expressed gene detection algorithm

A new RNA sequencing analysis method uses the Lomb-Scargle periodogram to efficiently identify genes associated with pseudotime across complex single-cell trajectories...

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rna-seqblog.com /3 weeks ago

Long-read RNA sequencing reveals how neurons choose alternative RNA endings

Long-read RNA sequencing and APALORD reveal how alternative polyadenylation changes during neuronal differentiation and identify new patterns of RNA processing across species...

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bioengineer.org /2 weeks ago

Where a Gene Sits on the Bacterial Chromosome May Shape Its Expression Through Selection

A new PLOS Genetics study finds that bacterial gene positions along the chromosome show gradients in mean and growth-dependent expression consistent with selection shaped by replic...

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journals.plos.org /3 days ago

The role of gene regulatory evolution in weapon diversification: Insights from comparative genomics, chromatin profiling...

by Phillip L. Davidson, Isabel G. Manley, Armin P. Moczek Condition-responsive growth is a common feature of multicellular development, during which organisms integrate genetic an...

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journals.plos.org /1 month ago

Post-transcriptional regulation of Profilin-2 by microRNAs and RNA-binding proteins forms a critical regulatory node for...

by Carolyn Sangokoya, Isabella R. Rosso, Rana Ghandehari-Alavijeh, Robert Blelloch Post-transcriptional control by RNA binding proteins (RBPs) and microRNAs play central roles in...

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rna-seqblog.com /1 month ago

A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction

RNA sequencing reveals that calorie restriction drives dose-responsive alternative splicing across multiple tissues, affecting mitochondrial, translational, and RNA quality-control...

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webwire.com /1 month ago

New method allows scientists to follow gene activity over time in the same cells

The following press release was issued by the Broad Institute of MIT and Harvard. - - In recent years, scientists have built methods to measure a cell's transcriptome, or all t...

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journals.plos.org /1 month ago

Not every gene is special: Modelling scale controls the false discovery rate when analysing high-throughput sequencing d...

by Scott J. Dos Santos, Andreea C. Murariu, Justin D. Silverman, Gregory B. Gloor Differential expression/abundance analyses are commonplace in studies employing high-throughput s...

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rna-seqblog.com /1 month ago

Single-cell and single-embryo RNA sequencing

Single-cell and single-embryo RNA sequencing enables detailed analysis of gene expression and cell identity during the earliest stages of embryonic development...

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